TYOBP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TYOBP_HUMAN
• UniProt AC: O43914
• Protein Name: TYRO protein tyrosine kinase-binding protein
• Gene Name: TYROBP
• Organism: Homo sapiens (Human).
• Sequence Length: 113
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin..
• Protein Sequence: MGGLEPCSRLLLLPLLLAVSGLRPVQAQAQSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
85	Phosphorylation	ATRKQRITETESPYQ HHHHHHHHCCCCHHH	38.76	27486199
87	Phosphorylation	RKQRITETESPYQEL HHHHHHCCCCHHHHH	32.87	23532336
89	Phosphorylation	QRITETESPYQELQG HHHHCCCCHHHHHCC	36.01	28450419
91	Phosphorylation	ITETESPYQELQGQR HHCCCCHHHHHCCCC	24.73	21082442
99	Phosphorylation	QELQGQRSDVYSDLN HHHCCCCCHHHHHHC	24.44	28176486
102	Phosphorylation	QGQRSDVYSDLNTQR CCCCCHHHHHHCCCC	11.06	25587033
103	Phosphorylation	GQRSDVYSDLNTQRP CCCCHHHHHHCCCCC	35.16	28176486
107	Phosphorylation	DVYSDLNTQRPYYK- HHHHHHCCCCCCCC-	33.00	24719451
111	Phosphorylation	DLNTQRPYYK----- HHCCCCCCCC-----	26.52	25587033
112	Phosphorylation	LNTQRPYYK------ HCCCCCCCC------	16.95	25587033

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
91	Y	Phosphorylation	Kinase	SYK	P43405	GPS
91	Y	Phosphorylation	Kinase	SYK	Q15046	PhosphoELM
102	Y	Phosphorylation	Kinase	SYK	P43405	GPS
102	Y	Phosphorylation	Kinase	SYK	Q15046	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TYOBP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TYOBP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIRB1_HUMAN	SIRPB1	physical	10940905
SIRBL_HUMAN	SIRPB1	physical	10940905

Drug and Disease Associations

• Kegg Disease
• H00438: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); Nasu-Hakola di
• OMIM Disease
• 221770: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-91, AND MASSSPECTROMETRY.
PubMed: 19369195

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-91, AND MASSSPECTROMETRY.
PubMed: 18083107