dbPTM

SIRBL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SIRBL_HUMAN
UniProt AC	Q5TFQ8
Protein Name	Signal-regulatory protein beta-1 isoform 3
Gene Name	SIRPB1
Organism	Homo sapiens (Human).
Sequence Length	398
Subcellular Localization	Membrane Single-pass type I membrane protein.
Protein Description	Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes..
Protein Sequence	MPVPASWPHLPSPFLLMTLLLGRLTGVAGEEELQVIQPDKSISVAAGESATLHCTVTSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRISNITPADAGTYYCVKFRKGSPDHVEFKSGAGTELSVRAKPSAPVVSGPAARATPQHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPAGDSVSYSIHSTAKVVLTREDVHSQVICEVAHVTLQGDPLRGTANLSETIRVPPTLEVTQQPVRAENQVNVTCQVRKFYPQRLQLTWLENGNVSRTETASTLTENKDGTYNWMSWLLVNVSAHRDDVKLTCQVEHDGQPAVSKSHDLKVSAHPKEQGSNTAPGPALASAAPLLIAFLLGPKVLLVVGVSVIYVYWKQKA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
182	Ubiquitination	SPRDITLKWFKNGNE CCCCEEEEEEECCCC	41.77	21890473
244	N-linked_Glycosylation	DPLRGTANLSETIRV CCCCCCCCHHCEEEC	43.89	UniProtKB CARBOHYD
291	N-linked_Glycosylation	LTWLENGNVSRTETA EEEEECCCCCEEEEC	39.92	UniProtKB CARBOHYD
318	N-linked_Glycosylation	WMSWLLVNVSAHRDD EEEEEEEEEECCCCC	23.23	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SIRBL_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SIRBL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SIRBL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TYOBP_HUMAN	TYROBP	physical	10604985
TYOBP_HUMAN	TYROBP	physical	10940905
KSYK_HUMAN	SYK	physical	10940905
RBPMS_HUMAN	RBPMS	physical	25416956

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SIRBL_HUMAN

Related Literatures of Post-Translational Modification