| UniProt ID | HRG1_HUMAN | |
|---|---|---|
| UniProt AC | Q6P1K1 | |
| Protein Name | Heme transporter HRG1 | |
| Gene Name | SLC48A1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 146 | |
| Subcellular Localization |
Endosome membrane Multi-pass membrane protein . Lysosome membrane Multi-pass membrane protein . |
|
| Protein Description | Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.. | |
| Protein Sequence | MAPSRLQLGLRAAYSGISSVAGFSIFLVWTVVYRQPGTAAMGGLAGVLALWVLVTHVMYMQDYWRTWLKGLRGFFFVGVLFSAVSIAAFCTFLVLAITRHQSLTDPTSYYLSSVWSFISFKWAFLLSLYAHRYRADFADISILSDF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 38 | Phosphorylation | VVYRQPGTAAMGGLA EHHCCCCCHHHHHHH | 20.23 | 24043423 | |
| 55 | Phosphorylation | LALWVLVTHVMYMQD HHHHHHHHHHHHHHH | 12.46 | 24043423 | |
| 59 | Phosphorylation | VLVTHVMYMQDYWRT HHHHHHHHHHHHHHH | 7.19 | 24043423 | |
| 63 | Phosphorylation | HVMYMQDYWRTWLKG HHHHHHHHHHHHHHH | 4.66 | 24043423 | |
| 119 | Phosphorylation | SSVWSFISFKWAFLL HHHHHHHHHHHHHHH | 20.82 | 24719451 | |
| 141 | Phosphorylation | RADFADISILSDF-- CCCCCCCHHHCCC-- | 20.30 | 29691806 | |
| 144 | Phosphorylation | FADISILSDF----- CCCCHHHCCC----- | 34.99 | 29691806 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HRG1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HRG1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HRG1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| A4_HUMAN | APP | physical | 21832049 | |
| NDKB_HUMAN | NME2 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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