OIT3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OIT3_HUMAN
• UniProt AC: Q8WWZ8
• Protein Name: Oncoprotein-induced transcript 3 protein
• Gene Name: OIT3
• Organism: Homo sapiens (Human).
• Sequence Length: 545
• Subcellular Localization: Nucleus envelope . Can be secreted into blood.
• Protein Description: May be involved in hepatocellular function and development..
• Protein Sequence: MPPFLLLTCLFITGTSVSPVALDPCSAYISLNEPWRNTDHQLDESQGPPLCDNHVNGEWYHFTGMAGDAMPTFCIPENHCGTHAPVWLNGSHPLEGDGIVQRQACASFNGNCCLWNTTVEVKACPGGYYVYRLTKPSVCFHVYCGHFYDICDEDCHGSCSDTSECTCAPGTVLGPDRQTCFDENECEQNNGGCSEICVNLKNSYRCECGVGRVLRSDGKTCEDVEGCHNNNGGCSHSCLGSEKGYQCECPRGLVLSEDNHTCQVPVLCKSNAIEVNIPRELVGGLELFLTNTSCRGVSNGTHVNILFSLKTCGTVVDVVNDKIVASNLVTGLPKQTPGSSGDFIIRTSKLLIPVTCEFPRLYTISEGYVPNLRNSPLEIMSRNHGIFPFTLEIFKDNEFEEPYREALPTLKLRDSLYFGIEPVVHVSGLESLVESCFATPTSKIDEVLKYYLIRDGCVSDDSVKQYTSRDHLAKHFQVPVFKFVGKDHKEVFLHCRVLVCGVLDERSRCAQGCHRRMRRGAGGEDSAGLQGQTLTGGPIRIDWED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
89	N-linked_Glycosylation	THAPVWLNGSHPLEG CCCCEEECCCCCCCC	33.92	UniProtKB CARBOHYD
116	N-linked_Glycosylation	NGNCCLWNTTVEVKA CCCEEEEEEEEEEEE	16.96	UniProtKB CARBOHYD
131	Phosphorylation	CPGGYYVYRLTKPSV CCCCEEEEEECCCEE	5.47	22817900
220	Phosphorylation	VLRSDGKTCEDVEGC EECCCCCEECCCCCC	27.02	-
237	Phosphorylation	NNGGCSHSCLGSEKG CCCCCCCCCCCCCCC	8.51	-
241	Phosphorylation	CSHSCLGSEKGYQCE CCCCCCCCCCCEECC	24.16	-
245	Phosphorylation	CLGSEKGYQCECPRG CCCCCCCEECCCCCC	22.51	-
291	N-linked_Glycosylation	GLELFLTNTSCRGVS CEEEEEECCCCCCCC	31.94	19159218
299	N-linked_Glycosylation	TSCRGVSNGTHVNIL CCCCCCCCCCEEEEE	57.91	UniProtKB CARBOHYD
301	Phosphorylation	CRGVSNGTHVNILFS CCCCCCCCEEEEEEE	27.22	-
308	Phosphorylation	THVNILFSLKTCGTV CEEEEEEEECCCCCE	26.05	24719451
326	Phosphorylation	VNDKIVASNLVTGLP HCCEEEHHHHCCCCC	21.58	29396449
330	Phosphorylation	IVASNLVTGLPKQTP EEHHHHCCCCCCCCC	35.85	29396449
415	Phosphorylation	PTLKLRDSLYFGIEP CCCCCCCCEECCCEE	20.66	22210691
439	Phosphorylation	LVESCFATPTSKIDE HHHHHCCCCCHHHHH	13.57	22210691
442	Phosphorylation	SCFATPTSKIDEVLK HHCCCCCHHHHHHHH	28.90	22210691
526	Phosphorylation	RGAGGEDSAGLQGQT CCCCCCCCCCCCCCC	21.67	-
533	Phosphorylation	SAGLQGQTLTGGPIR CCCCCCCCCCCCCEE	32.86	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OIT3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OIT3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OIT3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of OIT3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-291, AND MASSSPECTROMETRY.
PubMed: 19159218