TT39B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TT39B_HUMAN
• UniProt AC: Q5VTQ0
• Protein Name: Tetratricopeptide repeat protein 39B
• Gene Name: TTC39B
• Organism: Homo sapiens (Human).
• Sequence Length: 682
• Protein Sequence: MDAVLACRLRGRGNRVAALRPRPRPGGSAGPSPFALLCAGLSPEPRAGVGSEFPAWFLGGSSQRRNMALLGSRAELEADEDVFEDALETISISSHSDMATSSLHFASCDTQQAPRQRGASTVSSSSSTKVDLKSGLEECAVALNLFLSNKFTDALELLRPWAKESMYHALGYSTIVVLQAVLTFEQQDIQNGISAMKDALQTCQKYRKKYTVVESFSSLLSRGSLEQLSEEEMHAEICYAECLLQKAALTFVQDENMINFIKGGLKIRTSYQIYKECLSILHEIQKNKLQQEFFYEFEGGVKLGSGAFNLMLSLLPARIIRLLEFIGFSGNRELGLLQLREGASGRSMRSALCCLTILAFHTYISLILGTGEVNVAEAERLLAPFLQQFPNGSLVLFYHARIELLKGNLEEAQEVFQKCISVQEEWKQFHHLCYWELMWINVFQQNWMQAYYYSDLLCKESKWSKATYVFLKAAILSMLPEEDVVATNENVVTLFRQVDSLKQRIAGKSIPTEKFAVRKARRYSASLPAPVKLILPALEMMYVWNGFSIVSKRKDLSENLLVTVEKAEAALQSQNFNSFSVDDECLVKLLKGCCLKNLQRPLQAELCYNHVVESEKLLKYDHYLVPFTLFELASLYKSQGEIDKAIKFLETARNNYKDYSLESRLHFRIQAALHLWRKPSSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Ubiquitination	PFALLCAGLSPEPRA HHHHHHCCCCCCCCC	26.20	29967540
100	Phosphorylation	SSHSDMATSSLHFAS CCCCCCCCCCEEEEC	16.53	24043423
101	Phosphorylation	SHSDMATSSLHFASC CCCCCCCCCEEEECC	22.74	24043423
102	Phosphorylation	HSDMATSSLHFASCD CCCCCCCCEEEECCC	22.85	24043423
107	Phosphorylation	TSSLHFASCDTQQAP CCCEEEECCCCCCCC	16.16	24043423
110	Phosphorylation	LHFASCDTQQAPRQR EEEECCCCCCCCHHH	27.23	24043423
120	Phosphorylation	APRQRGASTVSSSSS CCHHHCCCCCCCCCC	31.97	23911959
121	Phosphorylation	PRQRGASTVSSSSST CHHHCCCCCCCCCCC	24.71	23403867
123	Phosphorylation	QRGASTVSSSSSTKV HHCCCCCCCCCCCCC	25.29	23403867
124	Phosphorylation	RGASTVSSSSSTKVD HCCCCCCCCCCCCCC	29.87	23403867
125	Phosphorylation	GASTVSSSSSTKVDL CCCCCCCCCCCCCCC	22.32	29396449
126	Phosphorylation	ASTVSSSSSTKVDLK CCCCCCCCCCCCCCC	43.93	29396449
127	Phosphorylation	STVSSSSSTKVDLKS CCCCCCCCCCCCCCC	33.91	23403867
128	Phosphorylation	TVSSSSSTKVDLKSG CCCCCCCCCCCCCCC	36.71	29396449
134	Phosphorylation	STKVDLKSGLEECAV CCCCCCCCCHHHHHH	56.77	-
136	Ubiquitination	KVDLKSGLEECAVAL CCCCCCCHHHHHHHH	6.90	29967540
148	Phosphorylation	VALNLFLSNKFTDAL HHHHHHHCCCCHHHH	30.55	-
205	Ubiquitination	DALQTCQKYRKKYTV HHHHHHHHHHHHHHH	49.52	29967540
210	Phosphorylation	CQKYRKKYTVVESFS HHHHHHHHHHHHHHH	14.06	-
211	Phosphorylation	QKYRKKYTVVESFSS HHHHHHHHHHHHHHH	27.27	-
215	Phosphorylation	KKYTVVESFSSLLSR HHHHHHHHHHHHHHC	20.86	-
217	Phosphorylation	YTVVESFSSLLSRGS HHHHHHHHHHHHCCC	29.38	29759185
218	Phosphorylation	TVVESFSSLLSRGSL HHHHHHHHHHHCCCH	31.17	24719451
221	Phosphorylation	ESFSSLLSRGSLEQL HHHHHHHHCCCHHHC	39.63	24719451
239	Phosphorylation	EMHAEICYAECLLQK HHHHHHHHHHHHHHH	15.88	29759185
279	Phosphorylation	QIYKECLSILHEIQK HHHHHHHHHHHHHHH	34.46	28165663
509	Phosphorylation	KQRIAGKSIPTEKFA HHHHCCCCCCHHHHH	32.65	-
512	Phosphorylation	IAGKSIPTEKFAVRK HCCCCCCHHHHHHHH	50.57	-
514	Malonylation	GKSIPTEKFAVRKAR CCCCCHHHHHHHHHH	40.89	26320211
523	Phosphorylation	AVRKARRYSASLPAP HHHHHHHHCCCCCCC	11.75	30108239
524	Phosphorylation	VRKARRYSASLPAPV HHHHHHHCCCCCCCH	15.01	30266825
526	Phosphorylation	KARRYSASLPAPVKL HHHHHCCCCCCCHHH	29.01	30266825
563	Phosphorylation	LSENLLVTVEKAEAA CCCCEEEEHHHHHHH	23.94	29083192
656	Phosphorylation	LETARNNYKDYSLES HHHHHHHCCCCCHHH	14.58	27174698
659	Phosphorylation	ARNNYKDYSLESRLH HHHHCCCCCHHHHHH	15.82	27174698
660	Phosphorylation	RNNYKDYSLESRLHF HHHCCCCCHHHHHHH	35.48	27174698
663	Phosphorylation	YKDYSLESRLHFRIQ CCCCCHHHHHHHHHH	45.49	27174698
680	Phosphorylation	LHLWRKPSSD----- HHHHCCCCCC-----	50.61	29514088
681	Phosphorylation	HLWRKPSSD------ HHHCCCCCC------	56.73	29514088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TT39B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TT39B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TT39B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CH60_HUMAN	HSPD1	physical	26186194
IF2M_HUMAN	MTIF2	physical	26186194
PPCEL_HUMAN	PREPL	physical	26186194
ADRO_HUMAN	FDXR	physical	26186194
CH60_HUMAN	HSPD1	physical	28514442
ADRO_HUMAN	FDXR	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.