NALCN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NALCN_HUMAN
• UniProt AC: Q8IZF0
• Protein Name: Sodium leak channel non-selective protein
• Gene Name: NALCN
• Organism: Homo sapiens (Human).
• Sequence Length: 1738
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Regulates the resting membrane potential and controls neuronal excitability. [PubMed: 17448995 Neuropeptides such as neurotensin and substance P (SP) stimulate the firing of action potentials by activating NALCN through a SRC family kinases-dependent pathway. In addition to its baseline activity, NALCN activity is enhanced/modulated by several GPCRs. Required for normal respiratory rhythm and neonatal survival. Involved in systemic osmoregulation by controlling the serum sodium concentration. NALCN is partly responsible for the substance P-induced depolarization and regulation of the intestinal pace-making activity in the interstitial cells of Cajal. Plays a critical role in both maintenance of spontaneous firing of substantia nigra pars reticulata (SNr) neurons and physiological modulation of SNr neuron excitability (By similarity]
• Protein Sequence: MLKRKQSSRVEAQPVTDFGPDESLSDNADILWINKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFTYFQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDRFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMVKISKLPSDFTVPKIRESFMKQFIDRQQQDTCCLLRSLPTTSSSSCDHSKRSAIEDNKYIDQKLRKSVFSIRARNLLEKETAVTKILRACTRQRMLSGSFEGQPAKERSILSVQHHIRQERRSLRHGSNSQRISRGKSLETLTQDHSNTVRYRNAQREDSEIKMIQEKKEQAEMKRKVQEEELRENHPYFDKPLFIVGREHRFRNFCRVVVRARFNASKTDPVTGAVKNTKYHQLYDLLGLVTYLDWVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPIHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEVDLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEEEVAKQTIRMWLKKCLKRIRAKQQQSCSIIHSLRESQQQELSRFLNPPSIETTQPSEDTNANSQDNSMQPETSSQQQLLSPTLSDRGGSRQDAADAGKPQRKFGQWRLPSAPKPISHSVSSVNLRFGGRTTMKSVVCKMNPMTDAASCGSEVKKWWTRQLTVESDESGDDLLDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	INKPWVHSLLRICAI ECCHHHHHHHHHHHH	21.34	24719451
165	Phosphorylation	FRFELPRTRITNILK EEECCCCCHHHHHHH	25.20	-
489	Phosphorylation	VVRLIKISPALEDFV HHHHHCCCHHHHHHH	10.10	-
497	Phosphorylation	PALEDFVYKIFGPGK HHHHHHHHHHHCCCC	9.81	22817900
623	Phosphorylation	QSEANADTKEKLPLR HHHCCCCCCCCCCHH	38.40	-
651	Phosphorylation	VKISKLPSDFTVPKI EEEECCCCCCCHHHH	56.65	-
740	Phosphorylation	CTRQRMLSGSFEGQP HHHHHHHCCCCCCCC	24.05	23663014
742	Phosphorylation	RQRMLSGSFEGQPAK HHHHHCCCCCCCCCH	19.42	23663014
795	Phosphorylation	DHSNTVRYRNAQRED CCCCHHHHHHCCCCC	12.13	28152594
803	Phosphorylation	RNAQREDSEIKMIQE HHCCCCCHHHHHHHH	36.15	30619164
886	Phosphorylation	YDLLGLVTYLDWVMI HHHHHHHHHHHHHHH	24.33	23401153
902	Phosphorylation	VTICSCISMMFESPF HHHHHHHHHHHCCCH	14.44	23401153
907	Phosphorylation	CISMMFESPFRRVMH HHHHHHCCCHHHHHC	20.34	23401153
917	Phosphorylation	RRVMHAPTLQIAEYV HHHHCCCHHHHHHHH	31.88	21403953
923	Phosphorylation	PTLQIAEYVFVIFMS CHHHHHHHHHHHHHH	7.08	21403953
962	Phosphorylation	GVMDIFIYLVSLIFL HHHHHHHHHHHHHHH	7.12	23401153
965	Phosphorylation	DIFIYLVSLIFLCWM HHHHHHHHHHHHHHC	17.10	23401153
980	Phosphorylation	PQNVPAESGAQLLMV CCCCCCCCHHHHHHH	41.35	23401153
1066	Phosphorylation	GIFRINVSVSKNLNL CEEEEEEEEECCCCC	19.04	-
1068	Phosphorylation	FRINVSVSKNLNLKL EEEEEEEECCCCCEE	14.34	-
1069	Acetylation	RINVSVSKNLNLKLR EEEEEEECCCCCEEC	64.40	20167786
1113	Phosphorylation	LALFEVLSLKGWVEV HHHHHHHHCCCCEEE	32.96	24719451
1169	Phosphorylation	NKGTALLTVDQRRWE CCCEEEEEECHHHHH	23.92	22210691
1228	Phosphorylation	LAQSVLLSVKWDVED HHHHHHHHCCCCCCC	19.93	24719451
1298	Phosphorylation	HFALLNAYTYMMGAC HHHHHHHHHHHHHHH	9.42	-
1327	Phosphorylation	TLKMLLLTVVVSMYK HHHHHHHHHHHHHHH	15.95	26270265
1331	Phosphorylation	LLLTVVVSMYKSFFI HHHHHHHHHHHHHHH	12.56	26270265
1333	Phosphorylation	LTVVVSMYKSFFIIV HHHHHHHHHHHHHHH	8.93	26270265
1362	Phosphorylation	VLFGTVKYGENINRH HHHCCCCCCCCCCCC	25.90	24927040
1571	Phosphorylation	EEEVAKQTIRMWLKK HHHHHHHHHHHHHHH	15.16	27422710
1590	Phosphorylation	IRAKQQQSCSIIHSL HHHHHHHHHHHHHHH	12.90	24114839
1596	Phosphorylation	QSCSIIHSLRESQQQ HHHHHHHHHHHHHHH	20.79	24719451
1600	Phosphorylation	IIHSLRESQQQELSR HHHHHHHHHHHHHHH	27.19	22210691
1680	Phosphorylation	PSAPKPISHSVSSVN CCCCCCCCCCCCEEE	20.45	29507054
1682	Phosphorylation	APKPISHSVSSVNLR CCCCCCCCCCEEEEE	19.53	29507054
1684	Phosphorylation	KPISHSVSSVNLRFG CCCCCCCCEEEEEEC	31.42	29507054
1685	Phosphorylation	PISHSVSSVNLRFGG CCCCCCCEEEEEECC	16.93	29507054

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NALCN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NALCN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NALCN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSD11_HUMAN	PSMD11	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615419: Hypotonia, infantile, with psychomotor retardation and characteristic facies (IHPRF)
• 616266: Congenital contractures of the limbs and face, hypotonia, and developmental delay (CLIFAHDD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-497, AND MASSSPECTROMETRY.
PubMed: 15592455