TM100_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM100_HUMAN
• UniProt AC: Q9NV29
• Protein Name: Transmembrane protein 100
• Gene Name: TMEM100
• Organism: Homo sapiens (Human).
• Sequence Length: 134
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Membrane ; Multi-pass membrane protein . Perikaryon. Cytoplasm, perinuclear region. Endoplasmic reticulum. Colocalized with HSPA5 in the endoplasmic reticulum (ER). Enriched in ER microsome. Colocalized wit
• Protein Description: Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex..
• Protein Sequence: MTEEPIKEILGAPKAHMAATMEKSPKSEVVITTVPLVSEIQLMAATGGTELSCYRCIIPFAVVVFIAGIVVTAVAYSFNSHGSIISIFGLVVLSSGLFLLASSALCWKVRQRSKKAKRRESQTALVANQRSLFA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Ubiquitination	-MTEEPIKEILGAPK -CCCHHHHHHHCCCC	49.79	22505724
7	Ubiquitination	-MTEEPIKEILGAPK -CCCHHHHHHHCCCC	49.79	-
20	Phosphorylation	PKAHMAATMEKSPKS CCHHHHHHCCCCCCC	19.14	29759185
23	Ubiquitination	HMAATMEKSPKSEVV HHHHHCCCCCCCCEE	62.32	-
24	Phosphorylation	MAATMEKSPKSEVVI HHHHCCCCCCCCEEE	25.01	29759185
27	Phosphorylation	TMEKSPKSEVVITTV HCCCCCCCCEEEEEC	38.72	-
121	Phosphorylation	KKAKRRESQTALVAN HHHHHHHHHHHHHHC	30.90	23911959
123	Phosphorylation	AKRRESQTALVANQR HHHHHHHHHHHHCHH	31.10	30108239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM100_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM100_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM100_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TMM79_HUMAN	TMEM79	physical	25416956
CCD57_HUMAN	CCDC57	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.