ZBED4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZBED4_HUMAN
• UniProt AC: O75132
• Protein Name: Zinc finger BED domain-containing protein 4
• Gene Name: ZBED4
• Organism: Homo sapiens (Human).
• Sequence Length: 1171
• Subcellular Localization: Nucleus. Cytoplasm.
• Protein Sequence: MENNLKTCPKEDGDFVSDKIKFKIEEEDDDGIPPDSLERMDFKSEQEDMKQTDSGGERAGLGGTGCSCKPPGKYLSAESEDDYGALFSQYSSTLYDVAMEAVTQSLLSSRNMSSRKKSPAWKHFFISPRDSTKAICMYCVKEFSRGKNEKDLSTSCLMRHVRRAHPTVLIQENGSVSAVSSFPSPSLLLPPQPADAGDLSTILSPIKLVQKVASKIPSPDRITEESVSVVSSEEISSDMSVSEKCGREEALVGSSPHLPALHYDEPAENLAEKSLPLPKSTSGSRRRSAVWKHFYLSPLDNSKAVCIHCMNEFSRGKNGKDLGTSCLIRHMWRAHRAIVLQENGGTGIPPLYSTPPTLLPSLLPPEGELSSVSSSPVKPVRESPSASSSPDRLTEDLQSHLNPGDGLMEDVAAFSSSDDIGEASASSPEKQQADGLSPRLFESGAIFQQNKKVMKRLKSEVWHHFSLAPMDSLKAECRYCGCAISRGKKGDVGTSCLMRHLYRRHPEVVGSQKGFLGASLANSPYATLASAESSSSKLTDLPTVVTKNNQVMFPVNSKKTSKLWNHFSICSADSTKVVCLHCGRTISRGKKPTNLGTSCLLRHLQRFHSNVLKTEVSETARPSSPDTRVPRGTELSGASSFDDTNEKFYDSHPVAKKITSLIAEMIALDLQPYSFVDNVGFNRLLEYLKPQYSLPAPSYFSRTAIPGMYDNVKQIIMSHLKEAESGVIHFTSGIWMSNQTREYLTLTAHWVSFESPARPRCDDHHCSALLDVSQVDCDYSGNSIQKQLECWWEAWVTSTGLQVGITVTDNASIGKTLNEGEHSSVQCFSHTVNLIVSEAIKSQRMVQNLLSLARKICERVHRSPKAKEKLAELQREYALPQHHLIQDVPSKWSTSFHMLERLIEQKRAINEMSVECNFRELISCDQWEVMQSVCRALKPFEAASREMSTQMSTLSQVIPMVHILNRKVEMLFEETMGIDTMLRSLKEAMVSRLSATLHDPRYVFATLLDPRYKASLFTEEEAEQYKQDLIRELELMNSTSEDVAASHRCDAGSPSKDSAAEENLWSLVAKVKKKDPREKLPEAMVLAYLEEEVLEHSCDPLTYWNLKKASWPGLSALAVRFLGCPPSIVPSEKLFNTPTENGSLGQSRLMMEHFEKLIFLKVNLPLIYFQY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Ubiquitination	DGDFVSDKIKFKIEE CCCCCCCCEEEEEEE	40.05	29967540
19	Acetylation	DGDFVSDKIKFKIEE CCCCCCCCEEEEEEE	40.05	25953088
43	Ubiquitination	SLERMDFKSEQEDMK HHHCCCCCHHHHHHH	49.14	29967540
43	Sumoylation	SLERMDFKSEQEDMK HHHCCCCCHHHHHHH	49.14	28112733
50	Ubiquitination	KSEQEDMKQTDSGGE CHHHHHHHHCCCCCC	63.47	-
69	Ubiquitination	GGTGCSCKPPGKYLS CCCCCCCCCCCCCCC	37.64	29967540
108	Phosphorylation	AVTQSLLSSRNMSSR HHHHHHHHCCCCCCC	32.32	24719451
109	Phosphorylation	VTQSLLSSRNMSSRK HHHHHHHCCCCCCCC	27.87	24719451
118	Phosphorylation	NMSSRKKSPAWKHFF CCCCCCCCCCHHHEE	23.92	-
127	Phosphorylation	AWKHFFISPRDSTKA CHHHEEECCCCCCHH	14.55	21815630
141	Ubiquitination	AICMYCVKEFSRGKN HHHHHHHHHHHCCCC	49.86	-
147	Ubiquitination	VKEFSRGKNEKDLST HHHHHCCCCHHHCCH	61.90	29967540
150	Ubiquitination	FSRGKNEKDLSTSCL HHCCCCHHHCCHHHH	73.66	29967540
211	Ubiquitination	SPIKLVQKVASKIPS CHHHHHHHHHHCCCC	32.08	29967540
215	Acetylation	LVQKVASKIPSPDRI HHHHHHHCCCCCCCC	49.23	25953088
218	Phosphorylation	KVASKIPSPDRITEE HHHHCCCCCCCCCCC	42.79	-
223	Phosphorylation	IPSPDRITEESVSVV CCCCCCCCCCEEEEE	34.30	29900121
226	Phosphorylation	PDRITEESVSVVSSE CCCCCCCEEEEECHH	17.29	29900121
231	Phosphorylation	EESVSVVSSEEISSD CCEEEEECHHHHHCC	29.85	21712546
240	Phosphorylation	EEISSDMSVSEKCGR HHHHCCCCHHHHHCC	27.73	29900121
242	Phosphorylation	ISSDMSVSEKCGREE HHCCCCHHHHHCCHH	24.83	29900121
254	Phosphorylation	REEALVGSSPHLPAL CHHHHCCCCCCCCCC	32.96	25159151
255	Phosphorylation	EEALVGSSPHLPALH HHHHCCCCCCCCCCC	15.48	25159151
263	Phosphorylation	PHLPALHYDEPAENL CCCCCCCCCCHHHHH	23.89	26074081
273	Ubiquitination	PAENLAEKSLPLPKS HHHHHHHHCCCCCCC	52.24	29967540
274	Phosphorylation	AENLAEKSLPLPKST HHHHHHHCCCCCCCC	27.07	-
279	Ubiquitination	EKSLPLPKSTSGSRR HHCCCCCCCCCCCHH	74.23	29967540
288	Phosphorylation	TSGSRRRSAVWKHFY CCCCHHHHHHHHHEE	25.93	23882029
295	Phosphorylation	SAVWKHFYLSPLDNS HHHHHHEEECCCCCC	13.14	21712546
297	Phosphorylation	VWKHFYLSPLDNSKA HHHHEEECCCCCCCC	16.43	25159151
320	Ubiquitination	FSRGKNGKDLGTSCL HHCCCCCCCCCHHHH	60.21	29967540
370	Phosphorylation	LPPEGELSSVSSSPV CCCCCCCCCCCCCCC	25.13	28348404
371	Phosphorylation	PPEGELSSVSSSPVK CCCCCCCCCCCCCCC	38.35	28348404
373	Phosphorylation	EGELSSVSSSPVKPV CCCCCCCCCCCCCCC	27.35	26074081
374	Phosphorylation	GELSSVSSSPVKPVR CCCCCCCCCCCCCCC	36.18	26074081
375	Phosphorylation	ELSSVSSSPVKPVRE CCCCCCCCCCCCCCC	26.63	26074081
385	Phosphorylation	KPVRESPSASSSPDR CCCCCCCCCCCCCCH	50.49	27794612
387	Phosphorylation	VRESPSASSSPDRLT CCCCCCCCCCCCHHH	35.37	27794612
388	Phosphorylation	RESPSASSSPDRLTE CCCCCCCCCCCHHHH	45.68	27794612
389	Phosphorylation	ESPSASSSPDRLTED CCCCCCCCCCHHHHH	28.46	27794612
424	Phosphorylation	SDDIGEASASSPEKQ CCCHHHHCCCCHHHH	25.12	26074081
426	Phosphorylation	DIGEASASSPEKQQA CHHHHCCCCHHHHHC	43.88	26074081
427	Phosphorylation	IGEASASSPEKQQAD HHHHCCCCHHHHHCC	36.47	26074081
437	Phosphorylation	KQQADGLSPRLFESG HHHCCCCCHHHHHCC	17.32	30576142
443	Phosphorylation	LSPRLFESGAIFQQN CCHHHHHCCHHHHHC	26.62	28555341
451	Ubiquitination	GAIFQQNKKVMKRLK CHHHHHCHHHHHHHH	42.27	29967540
459	Phosphorylation	KVMKRLKSEVWHHFS HHHHHHHHHHHHHHC	41.81	-
466	Phosphorylation	SEVWHHFSLAPMDSL HHHHHHHCCCCHHHH	21.18	-
489	Ubiquitination	CAISRGKKGDVGTSC CEECCCCCCCHHHHH	64.27	29967540
489	Sumoylation	CAISRGKKGDVGTSC CEECCCCCCCHHHHH	64.27	28112733
511	Phosphorylation	RHPEVVGSQKGFLGA HCHHHHCCCCCCCCH	19.67	-
519	Phosphorylation	QKGFLGASLANSPYA CCCCCCHHHCCCHHC	26.64	-
523	Phosphorylation	LGASLANSPYATLAS CCHHHCCCHHCHHHC	17.43	25159151
525	Phosphorylation	ASLANSPYATLASAE HHHCCCHHCHHHCCC	16.43	28122231
527	Phosphorylation	LANSPYATLASAESS HCCCHHCHHHCCCCC	19.60	21712546
530	Phosphorylation	SPYATLASAESSSSK CHHCHHHCCCCCCCC	35.36	21712546
533	Phosphorylation	ATLASAESSSSKLTD CHHHCCCCCCCCCCC	34.93	-
534	Phosphorylation	TLASAESSSSKLTDL HHHCCCCCCCCCCCC	30.09	-
535	Phosphorylation	LASAESSSSKLTDLP HHCCCCCCCCCCCCC	40.55	21712546
536	Phosphorylation	ASAESSSSKLTDLPT HCCCCCCCCCCCCCE	33.36	-
539	Phosphorylation	ESSSSKLTDLPTVVT CCCCCCCCCCCEEEE	38.95	-
546	Phosphorylation	TDLPTVVTKNNQVMF CCCCEEEECCCEEEE	24.58	22210691
547	Ubiquitination	DLPTVVTKNNQVMFP CCCEEEECCCEEEEE	42.14	-
559	Ubiquitination	MFPVNSKKTSKLWNH EEECCCCCCHHHCCC	58.83	-
571	Phosphorylation	WNHFSICSADSTKVV CCCEEEECCCCCEEE	33.18	28450419
574	Phosphorylation	FSICSADSTKVVCLH EEEECCCCCEEEEEE	29.82	28450419
575	Phosphorylation	SICSADSTKVVCLHC EEECCCCCEEEEEEC	28.53	30576142
593	Phosphorylation	ISRGKKPTNLGTSCL ECCCCCCCCHHHHHH	52.54	-
597	Phosphorylation	KKPTNLGTSCLLRHL CCCCCHHHHHHHHHH	21.31	-
598	Phosphorylation	KPTNLGTSCLLRHLQ CCCCHHHHHHHHHHH	10.85	-
609	Phosphorylation	RHLQRFHSNVLKTEV HHHHHHHHCCCEEEC	26.39	30576142
614	Phosphorylation	FHSNVLKTEVSETAR HHHCCCEEECCCCCC	37.14	23663014
617	Phosphorylation	NVLKTEVSETARPSS CCCEEECCCCCCCCC	24.01	29255136
617	O-linked_Glycosylation	NVLKTEVSETARPSS CCCEEECCCCCCCCC	24.01	30379171
619	Phosphorylation	LKTEVSETARPSSPD CEEECCCCCCCCCCC	22.06	29255136
623	Phosphorylation	VSETARPSSPDTRVP CCCCCCCCCCCCCCC	49.28	23401153
624	Phosphorylation	SETARPSSPDTRVPR CCCCCCCCCCCCCCC	29.49	23401153
627	Phosphorylation	ARPSSPDTRVPRGTE CCCCCCCCCCCCCCC	36.63	29255136
633	Phosphorylation	DTRVPRGTELSGASS CCCCCCCCCCCCCCC	34.72	26074081
639	Phosphorylation	GTELSGASSFDDTNE CCCCCCCCCCCCCCC	34.75	23401153
640	Phosphorylation	TELSGASSFDDTNEK CCCCCCCCCCCCCCC	31.96	29507054
647	Ubiquitination	SFDDTNEKFYDSHPV CCCCCCCCHHHCCHH	51.82	29967540
649	Phosphorylation	DDTNEKFYDSHPVAK CCCCCCHHHCCHHHH	27.83	27642862
651	Phosphorylation	TNEKFYDSHPVAKKI CCCCHHHCCHHHHHH	20.50	-
656	Ubiquitination	YDSHPVAKKITSLIA HHCCHHHHHHHHHHH	44.96	29967540
689	Ubiquitination	NRLLEYLKPQYSLPA HHHHHHHCCCCCCCC	29.22	-
718	Phosphorylation	NVKQIIMSHLKEAES HHHHHHHHHHHHHHC	18.43	25247763
869	Ubiquitination	RSPKAKEKLAELQRE CCHHHHHHHHHHHHH	52.90	-
891	Ubiquitination	LIQDVPSKWSTSFHM CCCCCCCHHHHHHHH	38.81	-
952	Phosphorylation	REMSTQMSTLSQVIP HHHHHHHHHHHHHHH	19.17	-
975	Phosphorylation	VEMLFEETMGIDTML HHHHHHHCCCHHHHH	17.31	-
986	Ubiquitination	DTMLRSLKEAMVSRL HHHHHHHHHHHHHHH	44.68	-
1013	Ubiquitination	TLLDPRYKASLFTEE HHCCHHHHHCCCCHH	32.55	29967540
1025	Phosphorylation	TEEEAEQYKQDLIRE CHHHHHHHHHHHHHH	11.34	-
1026	Ubiquitination	EEEAEQYKQDLIREL HHHHHHHHHHHHHHH	36.71	29967540
1038	Phosphorylation	RELELMNSTSEDVAA HHHHHHCCCCHHHHH	21.24	26074081
1039	Phosphorylation	ELELMNSTSEDVAAS HHHHHCCCCHHHHHH	31.00	26074081
1040	Phosphorylation	LELMNSTSEDVAASH HHHHCCCCHHHHHHC	31.46	26074081
1046	Phosphorylation	TSEDVAASHRCDAGS CCHHHHHHCCCCCCC	11.17	26074081
1053	Phosphorylation	SHRCDAGSPSKDSAA HCCCCCCCCCCCCHH	27.93	22617229
1055	Phosphorylation	RCDAGSPSKDSAAEE CCCCCCCCCCCHHHH	51.28	28348404
1056	Ubiquitination	CDAGSPSKDSAAEEN CCCCCCCCCCHHHHC	60.12	29967540
1058	Phosphorylation	AGSPSKDSAAEENLW CCCCCCCCHHHHCHH	32.87	21712546
1066	Phosphorylation	AAEENLWSLVAKVKK HHHHCHHHHHHHHCC	19.01	23312004
1070	Ubiquitination	NLWSLVAKVKKKDPR CHHHHHHHHCCCCHH	47.29	29967540
1133	Ubiquitination	PSIVPSEKLFNTPTE CHHCCHHHHCCCCCC	63.82	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZBED4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZBED4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZBED4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZBED4_HUMAN	ZBED4	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.