CSDC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSDC2_HUMAN
• UniProt AC: Q9Y534
• Protein Name: Cold shock domain-containing protein C2
• Gene Name: CSDC2
• Organism: Homo sapiens (Human).
• Sequence Length: 153
• Subcellular Localization: Nucleus. Cytoplasm. PIPPin-RNA complexes are located to the nucleus..
• Protein Description: RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity)..
• Protein Sequence: MTSESTSPPVVPPLHSPKSPVWPTFPFHREGSRVWERGGVPPRDLPSPLPTKRTRTYSATARASAGPVFKGVCKQFSRSQGHGFITPENGSEDIFVHVSDIEGEYVPVEGDEVTYKMCPIPPKNQKFQAVEVVLTQLAPHTPHETWSGQVVGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTSESTSPP ------CCCCCCCCC	41.00	28857561
5	Phosphorylation	---MTSESTSPPVVP ---CCCCCCCCCCCC	33.67	29523821
6	Phosphorylation	--MTSESTSPPVVPP --CCCCCCCCCCCCC	41.00	28857561
7	Phosphorylation	-MTSESTSPPVVPPL -CCCCCCCCCCCCCC	36.16	30266825
16	Phosphorylation	PVVPPLHSPKSPVWP CCCCCCCCCCCCCCC	41.53	30266825
19	Phosphorylation	PPLHSPKSPVWPTFP CCCCCCCCCCCCCCC	28.24	30266825
32	Phosphorylation	FPFHREGSRVWERGG CCCCCCCCCHHHCCC	20.93	24719451
47	Phosphorylation	VPPRDLPSPLPTKRT CCCCCCCCCCCCCCC	46.49	25463755
51	Phosphorylation	DLPSPLPTKRTRTYS CCCCCCCCCCCEEEE	40.62	23186163
52	Ubiquitination	LPSPLPTKRTRTYSA CCCCCCCCCCEEEEE	50.24	-
56	Phosphorylation	LPTKRTRTYSATARA CCCCCCEEEEEECHH	22.63	26699800
57	Phosphorylation	PTKRTRTYSATARAS CCCCCEEEEEECHHH	7.94	26699800
58	Phosphorylation	TKRTRTYSATARASA CCCCEEEEEECHHHC	20.66	30266825
60	Phosphorylation	RTRTYSATARASAGP CCEEEEEECHHHCCH	15.67	26699800
64	Phosphorylation	YSATARASAGPVFKG EEEECHHHCCHHHHH	28.36	27134283
70	Ubiquitination	ASAGPVFKGVCKQFS HHCCHHHHHHHHHHH	51.14	-
74	Ubiquitination	PVFKGVCKQFSRSQG HHHHHHHHHHHHHCC	52.55	-
105	Phosphorylation	VSDIEGEYVPVEGDE EEECCCEEECCCCCE	22.40	-
141	Phosphorylation	LTQLAPHTPHETWSG EEECCCCCCCCCCCC	25.86	27251275
145	Phosphorylation	APHTPHETWSGQVVG CCCCCCCCCCCCCCC	23.15	27251275
147	Phosphorylation	HTPHETWSGQVVGS- CCCCCCCCCCCCCC-	27.11	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
58	S	Phosphorylation	Kinase	AKT1	P31749	GPS
58	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
58	S	Phosphorylation	Kinase	SGK1	O00141	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSDC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSDC2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CSDC2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.