MMP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MMP3_HUMAN
• UniProt AC: P08254
• Protein Name: Stromelysin-1
• Gene Name: MMP3
• Organism: Homo sapiens (Human).
• Sequence Length: 477
• Subcellular Localization: Secreted, extracellular space, extracellular matrix .
• Protein Description: Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase..
• Protein Sequence: MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	CVAVCSAYPLDGAAR HHHHHHHCCCCCHHC	6.50	-
37	Phosphorylation	SMNLVQKYLENYYDL HHHHHHHHHHHHHHH	11.36	22817900
41	Phosphorylation	VQKYLENYYDLKKDV HHHHHHHHHHHHHHH	6.75	22817900
42	Phosphorylation	QKYLENYYDLKKDVK HHHHHHHHHHHHHHH	26.78	22817900
57	Phosphorylation	QFVRRKDSGPVVKKI HHHHHCCCCHHHHHH	48.29	28348404
81	Phosphorylation	EVTGKLDSDTLEVMR EEECCCCCCHHHHHC	42.82	22777824
116	Phosphorylation	WRKTHLTYRIVNYTP CCCCEEEEEEEECCC	12.52	-
120	N-linked_Glycosylation	HLTYRIVNYTPDLPK EEEEEEEECCCCCCH	32.37	UniProtKB CARBOHYD
121	Phosphorylation	LTYRIVNYTPDLPKD EEEEEEECCCCCCHH	14.57	-
127	Ubiquitination	NYTPDLPKDAVDSAV ECCCCCCHHHHHHHH	66.66	29967540
277	O-linked_Glycosylation	PETPLVPTEPVPPEP CCCCCCCCCCCCCCC	45.50	OGP
286	O-linked_Glycosylation	PVPPEPGTPANCDPA CCCCCCCCCCCCCCC	29.91	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MMP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MMP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MMP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PGCB_HUMAN	BCAN	physical	10986281
K319L_HUMAN	KIAA0319L	physical	26186194
MMP10_HUMAN	MMP10	physical	26186194
CLUS_HUMAN	CLU	physical	26186194
PTPRS_HUMAN	PTPRS	physical	26186194
CLN5_HUMAN	CLN5	physical	26186194
HBD_HUMAN	HBD	physical	26186194
NUCB1_HUMAN	NUCB1	physical	26186194
APOE_HUMAN	APOE	physical	26186194
TIMP3_HUMAN	TIMP3	physical	26186194
MMP10_HUMAN	MMP10	physical	28514442
APOE_HUMAN	APOE	physical	28514442
PTPRS_HUMAN	PTPRS	physical	28514442
NUCB1_HUMAN	NUCB1	physical	28514442
TIMP3_HUMAN	TIMP3	physical	28514442
LTBP1_HUMAN	LTBP1	physical	28514442
K319L_HUMAN	KIAA0319L	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614466: Coronary heart disease 6 (CHDS6)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.