MMP10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MMP10_HUMAN
• UniProt AC: P09238
• Protein Name: Stromelysin-2
• Gene Name: MMP10
• Organism: Homo sapiens (Human).
• Sequence Length: 476
• Subcellular Localization: Secreted, extracellular space, extracellular matrix .
• Protein Description: Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase..
• Protein Sequence: MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Acetylation	DVKQFRRKDSNLIVK HHHHHHHCCCCHHHH	62.34	20167786
62	Acetylation	DSNLIVKKIQGMQKF CCCHHHHHHHHHHHH	29.39	7966065
115	Phosphorylation	WRKTHLTYRIVNYTP CCCCEEEEEEEECCC	12.52	-
281	Phosphorylation	VPTKSVPSGSEMPAK CCCCCCCCCCCCCCC	53.44	-
283	Phosphorylation	TKSVPSGSEMPAKCD CCCCCCCCCCCCCCC	34.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MMP10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MMP10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MMP10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PGCB_HUMAN	BCAN	physical	10986281
GALA_HUMAN	GAL	physical	28514442
PCSK1_HUMAN	PCSK1N	physical	28514442
APOE_HUMAN	APOE	physical	28514442
TIMP1_HUMAN	TIMP1	physical	28514442
LTBP1_HUMAN	LTBP1	physical	28514442
TRAF7_HUMAN	TRAF7	physical	28514442
B4GT1_HUMAN	B4GALT1	physical	28514442
MA1A1_HUMAN	MAN1A1	physical	28514442
EMIL3_HUMAN	EMILIN3	physical	28514442
NUCB1_HUMAN	NUCB1	physical	28514442
TNFL9_HUMAN	TNFSF9	physical	28514442
NPTX1_HUMAN	NPTX1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.