dbPTM

GALA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GALA_HUMAN
UniProt AC	P22466
Protein Name	Galanin peptides
Gene Name	GAL
Organism	Homo sapiens (Human).
Sequence Length	123
Subcellular Localization	Secreted .
Protein Description	Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion..
Protein Sequence	MARGSALLLASLLLAAALSASAGLWSPAKEKRGWTLNSAGYLLGPHAVGNHRSFSDKNGLTSKRELRPEDDMKPGSFDRSIPENNIMRTIIEFLSFLHLKEAGALDRLLDLPAAASSEDIERS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	LLLAAALSASAGLWS HHHHHHHHHHCCCCC	18.56	-
35	O-linked_Glycosylation	AKEKRGWTLNSAGYL CHHHCCCEECCCHHH	20.91	55824207
53	Phosphorylation	HAVGNHRSFSDKNGL CCCCCCCCCCCCCCC	22.88	27134283
57	Ubiquitination	NHRSFSDKNGLTSKR CCCCCCCCCCCCCCC	52.28	27667366
63	Ubiquitination	DKNGLTSKRELRPED CCCCCCCCCCCCCHH	44.66	23503661
73	Ubiquitination	LRPEDDMKPGSFDRS CCCHHCCCCCCCCCC	53.90	23503661
76	Phosphorylation	EDDMKPGSFDRSIPE HHCCCCCCCCCCCCC	32.28	23312004
89	Phosphorylation	PENNIMRTIIEFLSF CCCHHHHHHHHHHHH	14.66	-
95	Phosphorylation	RTIIEFLSFLHLKEA HHHHHHHHHHHHHHC	30.96	-
116	Phosphorylation	LDLPAAASSEDIERS HCCCCHHCHHHHHCC	29.54	28355574
117	Phosphorylation	DLPAAASSEDIERS- CCCCHHCHHHHHCC-	34.26	25159151
123	Phosphorylation	SSEDIERS------- CHHHHHCC-------	31.61	30175587

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GALA_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GALA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GALA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GALA_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GALA_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteomic analysis of the human pituitary."; Beranova-Giorgianni S., Zhao Y., Desiderio D.M., Giorgianni F.; Pituitary 9:109-120(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117, AND MASSSPECTROMETRY.	16807684 [Abstract]
"Identification and characterization of phosphorylated proteins in thehuman pituitary."; Giorgianni F., Beranova-Giorgianni S., Desiderio D.M.; Proteomics 4:587-598(2004). Cited for: PHOSPHORYLATION AT SER-117.	14997482 [Abstract]