| UniProt ID | PGCB_HUMAN | |
|---|---|---|
| UniProt AC | Q96GW7 | |
| Protein Name | Brevican core protein | |
| Gene Name | BCAN | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 911 | |
| Subcellular Localization |
Isoform 1: Secreted, extracellular space, extracellular matrix. Isoform 2: Membrane Lipid-anchor, GPI-anchor. |
|
| Protein Description | May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.. | |
| Protein Sequence | MAQLFLPLLAALVLAQAPAALADVLEGDSSEDRAFRVRIAGDAPLQGVLGGALTIPCHVHYLRPPPSRRAVLGSPRVKWTFLSRGREAEVLVARGVRVKVNEAYRFRVALPAYPASLTDVSLALSELRPNDSGIYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSARYAFSFSGAQEACARIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREACYGDMDGFPGVRNYGVVDPDDLYDVYCYAEDLNGELFLGDPPEKLTLEEARAYCQERGAEIATTGQLYAAWDGGLDHCSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFLFPNQTGFPNKHSRFNVYCFRDSAQPSAIPEASNPASNPASDGLEAIVTVTETLEELQLPQEATESESRGAIYSIPIMEDGGGGSSTPEDPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDGESEASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREVGEATGGPELSGVPRGESEETGSSEGAPSLLPATRAPEGTRELEAPSEDNSGRTAPAGTSVQAQPVLPTDSASRGGVAVVPASGDCVPSPCHNGGTCLEEEEGVRCLCLPGYGGDLCDVGLRFCNPGWDAFQGACYKHFSTRRSWEEAETQCRMYGAHLASISTPEEQDFINNRYREYQWIGLNDRTIEGDFLWSDGVPLLYENWNPGQPDSYFLSGENCVVMVWHDQGQWSDVPCNYHLSYTCKMGLVSCGPPPELPLAQVFGRPRLRYEVDTVLRYRCREGLAQRNLPLIRCQENGRWEAPQISCVPRRPARALHPEEDPEGRQGRLLGRWKALLIPPSSPMPGP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 29 | Phosphorylation | ADVLEGDSSEDRAFR HHHHCCCCCCCCEEE | 46.62 | 25332170 | |
| 30 | Phosphorylation | DVLEGDSSEDRAFRV HHHCCCCCCCCEEEE | 48.53 | 25332170 | |
| 74 | Phosphorylation | SRRAVLGSPRVKWTF CHHHCCCCCCEEEEE | 12.84 | 30108239 | |
| 125 | O-linked_Glycosylation | TDVSLALSELRPNDS HHHHHHHHHCCCCCC | 29.04 | 28657654 | |
| 130 | N-linked_Glycosylation | ALSELRPNDSGIYRC HHHHCCCCCCCEEEE | 50.04 | UniProtKB CARBOHYD | |
| 337 | N-linked_Glycosylation | KTLFLFPNQTGFPNK EEEEECCCCCCCCCC | 44.72 | UniProtKB CARBOHYD | |
| 384 | O-linked_Glycosylation | LEAIVTVTETLEELQ CEEEEEEHHHHHHCC | 17.56 | OGP | |
| 418 | Phosphorylation | MEDGGGGSSTPEDPA EECCCCCCCCCCCHH | 34.02 | - | |
| 419 | Phosphorylation | EDGGGGSSTPEDPAE ECCCCCCCCCCCHHC | 51.78 | 24076635 | |
| 540 | O-linked_Glycosylation | PRVHGPPTETLPTPR CCCCCCCCCCCCCHH | 44.74 | 55829781 | |
| 542 | O-linked_Glycosylation | VHGPPTETLPTPRER CCCCCCCCCCCHHHC | 40.28 | 55829785 | |
| 569 | O-linked_Glycosylation | AREVGEATGGPELSG HHHHHHCCCCCCCCC | 38.07 | OGP | |
| 582 | Phosphorylation | SGVPRGESEETGSSE CCCCCCCCCCCCCCC | 43.48 | 29759185 | |
| 585 | Phosphorylation | PRGESEETGSSEGAP CCCCCCCCCCCCCCC | 38.01 | 28122231 | |
| 587 | Phosphorylation | GESEETGSSEGAPSL CCCCCCCCCCCCCCC | 32.41 | 28122231 | |
| 588 | Phosphorylation | ESEETGSSEGAPSLL CCCCCCCCCCCCCCC | 41.20 | 28122231 | |
| 646 (in isoform 2) | GPI-anchor | - | 17.97 | - | |
| 905 | O-linked_Glycosylation | KALLIPPSSPMPGP- EEEECCCCCCCCCC- | 41.54 | 19838169 | |
| 906 | O-linked_Glycosylation | ALLIPPSSPMPGP-- EEECCCCCCCCCC-- | 30.87 | 19838169 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PGCB_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PGCB_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PGCB_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| FBLN2_HUMAN | FBLN2 | physical | 11038354 | |
| FBX11_HUMAN | FBXO11 | physical | 26186194 | |
| CSPG2_HUMAN | VCAN | physical | 26186194 | |
| ULK3_HUMAN | ULK3 | physical | 26186194 | |
| REPI1_HUMAN | REPIN1 | physical | 26186194 | |
| CCYL1_HUMAN | CCNYL1 | physical | 26186194 | |
| CSPG2_HUMAN | VCAN | physical | 28514442 | |
| ULK3_HUMAN | ULK3 | physical | 28514442 | |
| CCYL1_HUMAN | CCNYL1 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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