CLN5_HUMAN - dbPTM
CLN5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CLN5_HUMAN
UniProt AC O75503
Protein Name Ceroid-lipofuscinosis neuronal protein 5
Gene Name CLN5
Organism Homo sapiens (Human).
Sequence Length 358
Subcellular Localization Ceroid-lipofuscinosis neuronal protein 5, secreted form: Lysosome .
Ceroid-lipofuscinosis neuronal protein 5: Membrane
Single-pass type II membrane protein . An amphipathic anchor region facilitates its association with the membrane.
Protein Description Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane. [PubMed: 22431521]
Protein Sequence MAQEVDTAQGAEMRRGAGAARGRASWCWALALLWLAVVPGWSRVSGIPSRRHWPVPYKRFDFRPKPDPYCQAKYTFCPTGSPIPVMEGDDDIEVFRLQAPVWEFKYGDLLGHLKIMHDAIGFRSTLTGKNYTMEWYELFQLGNCTFPHLRPEMDAPFWCNQGAACFFEGIDDVHWKENGTLVQVATISGNMFNQMAKWVKQDNETGIYYETWNVKASPEKGAETWFDSYDCSKFVLRTFNKLAEFGAEFKNIETNYTRIFLYSGEPTYLGNETSVFGPTGNKTLGLAIKRFYYPFKPHLPTKEFLLSLLQIFDAVIVHKQFYLFYNFEYWFLPMKFPFIKITYEEIPLPIRNKTLSGL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
65UbiquitinationKRFDFRPKPDPYCQA
CCCCCCCCCCCCCCE		58.7721890473
77GlutathionylationCQAKYTFCPTGSPIP
CCEEEEECCCCCCCC		1.9622555962
105UbiquitinationQAPVWEFKYGDLLGH
ECCEEEEECHHHHHH		36.4921890473
105UbiquitinationQAPVWEFKYGDLLGH
ECCEEEEECHHHHHH		36.49-
114UbiquitinationGDLLGHLKIMHDAIG
HHHHHHHEEEHHCCC		32.1021890473
114UbiquitinationGDLLGHLKIMHDAIG
HHHHHHHEEEHHCCC		32.1021890473
130N-linked_GlycosylationRSTLTGKNYTMEWYE
CCCCCCCCCEEEEHH		38.5624058541
143N-linked_GlycosylationYELFQLGNCTFPHLR
HHHEEECCCCCCCCC		30.1924058541
154UbiquitinationPHLRPEMDAPFWCNQ
CCCCCCCCCCCCCCC		49.8021890473
154UbiquitinationPHLRPEMDAPFWCNQ
CCCCCCCCCCCCCCC		49.8021890473
178N-linked_GlycosylationDDVHWKENGTLVQVA
CCCEEECCCEEEEEE		45.0524058541
179N-linked_GlycosylationDVHWKENGTLVQVAT
CCEEECCCEEEEEEE		22.8624058541
192N-linked_GlycosylationATISGNMFNQMAKWV
EEECCCHHHHHHHHH		7.1424058541
203N-linked_GlycosylationAKWVKQDNETGIYYE
HHHHHHCCCCCEEEE		46.3524058541
227N-linked_GlycosylationKGAETWFDSYDCSKF
CCCCCCCHHCCHHHH		37.5424058541
252N-linked_GlycosylationFGAEFKNIETNYTRI
HCCEEECCCCCCEEE		7.7224058541
255N-linked_GlycosylationEFKNIETNYTRIFLY
EEECCCCCCEEEEEE		24.3224058541
264UbiquitinationTRIFLYSGEPTYLGN
EEEEEECCCCEECCC		31.20-
271N-linked_GlycosylationGEPTYLGNETSVFGP
CCCEECCCCCEEECC		46.9424058541
281N-linked_GlycosylationSVFGPTGNKTLGLAI
EEECCCCCCCHHEEE		36.3024058541
283PhosphorylationFGPTGNKTLGLAIKR
ECCCCCCCHHEEEHH		30.02-
304N-linked_GlycosylationPHLPTKEFLLSLLQI
CCCCCHHHHHHHHHH		9.9124058541
320N-linked_GlycosylationDAVIVHKQFYLFYNF
HHHHHCCCEEEEECE		19.8324058541
322PhosphorylationVIVHKQFYLFYNFEY
HHHCCCEEEEECEEE		8.0724043423
330N-linked_GlycosylationLFYNFEYWFLPMKFP
EEECEEEEEECCCCC		4.9024058541
332PhosphorylationYNFEYWFLPMKFPFI
ECEEEEEECCCCCEE		2.22-
342PhosphorylationKFPFIKITYEEIPLP
CCCEEEEEECCCCCC		21.6324043423
343PhosphorylationFPFIKITYEEIPLPI
CCEEEEEECCCCCCC		18.2924043423
352N-linked_GlycosylationEIPLPIRNKTLSGL-
CCCCCCCCCCCCCC-		42.2424058541
401N-linked_Glycosylation--------------------------------------------------
--------------------------------------------------		24058541
401N-linked_Glycosylation--------------------------------------------------
--------------------------------------------------		24058541
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CLN5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CLN5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CLN5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CALX_HUMANCANXphysical
23464991
CLGN_HUMANCLGNphysical
23464991
SE1L1_HUMANSEL1Lphysical
23464991
GANAB_HUMANGANABphysical
23464991
ADT3_HUMANSLC25A6physical
23464991
ADT2_HUMANSLC25A5physical
23464991
OS9_HUMANOS9physical
23464991
ADT1_HUMANSLC25A4physical
23464991
DOPO_HUMANDBHphysical
23464991
AT2A2_HUMANATP2A2physical
23464991
CMC2_HUMANSLC25A13physical
23464991
CALR_HUMANCALRphysical
23464991
RCN2_HUMANRCN2physical
23464991
SFXN3_HUMANSFXN3physical
23464991
CALU_HUMANCALUphysical
23464991
AT1A3_HUMANATP1A3physical
23464991
RHG36_HUMANARHGAP36physical
23464991
TXTP_HUMANSLC25A1physical
23464991
S61A1_HUMANSEC61A1physical
23464991
GHC1_HUMANSLC25A22physical
23464991
ARF4_HUMANARF4physical
23464991
CDIPT_HUMANCDIPTphysical
23464991
XPO1_HUMANXPO1physical
23464991
RPN1_HUMANRPN1physical
23464991
M2OM_HUMANSLC25A11physical
23464991
CDS2_HUMANCDS2physical
23464991
SERA_HUMANPHGDHphysical
23464991
SPNS1_HUMANSPNS1physical
23464991
HMCS1_HUMANHMGCS1physical
23464991
FBX27_HUMANFBXO27physical
23464991
FBX6_HUMANFBXO6physical
23464991
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CLN5_HUMAN

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Related Literatures of Post-Translational Modification

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