RHG36_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RHG36_HUMAN
• UniProt AC: Q6ZRI8
• Protein Name: Rho GTPase-activating protein 36
• Gene Name: ARHGAP36
• Organism: Homo sapiens (Human).
• Sequence Length: 547
• Protein Description: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state..
• Protein Sequence: MGGCIPFLKAARALCPRIMPPLLLLSAFIFLVSVLGGAPGHNPDRRTKMVSIHSLSELERLKLQETAYHELVARHFLSEFKPDRALPIDRPNTLDKWFLILRGQQRAVSHKTFGISLEEVLVNEFTRRKHLELTATMQVEEATGQAAGRRRGNVVRRVFGRIRRFFSRRRNEPTLPREFTRRGRRGAVSVDSLAELEDGALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYVASVNVVRAMIDNWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVETSAEARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQDRPLLRVPREKEAKTGVSYFFP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31 (in isoform 2)	Ubiquitination	-	2.10	-
50	Ubiquitination	PDRRTKMVSIHSLSE CCHHCCEEEEECHHH	5.32	23503661
50 (in isoform 2)	Ubiquitination	-	5.32	-
54	Phosphorylation	TKMVSIHSLSELERL CCEEEEECHHHHHHH	31.74	29083192
56	Phosphorylation	MVSIHSLSELERLKL EEEEECHHHHHHHHC	43.05	29083192
62	Ubiquitination	LSELERLKLQETAYH HHHHHHHHCHHHHHH	55.11	23503661
69	Ubiquitination	KLQETAYHELVARHF HCHHHHHHHHHHHHH	21.32	23503661
81	Ubiquitination	RHFLSEFKPDRALPI HHHHHHCCCCCCCCC	41.79	23503661
136	Phosphorylation	KHLELTATMQVEEAT CCCEEEEEEEHHHHH	11.69	-
189	Phosphorylation	RGRRGAVSVDSLAEL CCCCCCCCHHHHHHH	21.48	29691806
192	Phosphorylation	RGAVSVDSLAELEDG CCCCCHHHHHHHCCH	27.59	29691806
227	Phosphorylation	LGSKRKMSLNPIAKQ HCCCCCCCCCHHHHH	28.20	25849741
252	Phosphorylation	FIEKHGLSAVGIFTL HHHHCCCCEEEEEEE	26.04	21060948
262	Phosphorylation	GIFTLEYSVQRVRQL EEEEEHHHHHHHHHH	11.46	-
302	Ubiquitination	KEFFRDMKDSLLPDD HHHHHHHHHHCCCHH	48.75	23503661
306	Ubiquitination	RDMKDSLLPDDLYMS HHHHHHCCCHHHHHH	5.17	23503661
329	Ubiquitination	PQDQLSALQLLVYLM CHHHHHHHHHHHHHC	3.11	23503661
341	O-linked_Glycosylation	YLMPPCHSDTLERLL HHCCCCCHHHHHHHH	38.72	29351928
343	O-linked_Glycosylation	MPPCHSDTLERLLKA CCCCCHHHHHHHHHH	33.27	29351928
355	Ubiquitination	LKALHKITENCEDSI HHHHHHHHHCCCCCC	26.42	23503661
411 (in isoform 2)	Ubiquitination	-	12.27	-
426	Ubiquitination	IDNWDVLFQVPPHIQ HHCCCEEECCCHHHH	7.46	23503661
430	Ubiquitination	DVLFQVPPHIQRQVA CEEECCCHHHHHHHH	38.05	23503661
434 (in isoform 2)	Ubiquitination	-	32.13	-
438	Ubiquitination	HIQRQVAKRVWKSSP HHHHHHHHHHHHCCH	48.94	23503661
442	Ubiquitination	QVAKRVWKSSPEALD HHHHHHHHCCHHHHH	37.89	23503661
444	Phosphorylation	AKRVWKSSPEALDFI HHHHHHCCHHHHHHH	24.04	22985185
453	Ubiquitination	EALDFIRRRNLRKIQ HHHHHHHHHCHHHHH	27.33	23503661
460 (in isoform 2)	Ubiquitination	-	33.79	-
465	Ubiquitination	KIQSARIKMEEDALL HHHHHCCCCCHHHCC	34.40	23503661
473	Phosphorylation	MEEDALLSDPVETSA CCHHHCCCCCCCCCH	40.49	29691806
478	Phosphorylation	LLSDPVETSAEARAA CCCCCCCCCHHHHHH	33.21	29691806
479	Ubiquitination	LSDPVETSAEARAAV CCCCCCCCHHHHHHH	15.59	23503661
479	Phosphorylation	LSDPVETSAEARAAV CCCCCCCCHHHHHHH	15.59	29691806
490	Phosphorylation	RAAVLAQSKPSDEGS HHHHHHCCCCCCCCC	40.71	29691806
491	Ubiquitination	AAVLAQSKPSDEGSS HHHHHCCCCCCCCCC	36.14	23503661
493	Phosphorylation	VLAQSKPSDEGSSEE HHHCCCCCCCCCCCC	52.62	29691806
497	Phosphorylation	SKPSDEGSSEEPAVP CCCCCCCCCCCCCCC	32.31	25849741
498	Phosphorylation	KPSDEGSSEEPAVPS CCCCCCCCCCCCCCC	57.76	29691806

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RHG36_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RHG36_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RHG36_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PPCEL_HUMAN	PREPL	physical	28514442
TBA3C_HUMAN	TUBA3C	physical	28514442
APOD_HUMAN	APOD	physical	28514442
ATG2B_HUMAN	ATG2B	physical	28514442
TTC19_HUMAN	TTC19	physical	28514442
PJA2_HUMAN	PJA2	physical	28514442
MAGD4_HUMAN	MAGED4B	physical	28514442
CLUS_HUMAN	CLU	physical	28514442
PTPRD_HUMAN	PTPRD	physical	28514442
STOM_HUMAN	STOM	physical	28514442
MUCL1_HUMAN	MUCL1	physical	28514442
CAND2_HUMAN	CAND2	physical	28514442
TRBP2_HUMAN	TARBP2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.