SPAT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPAT1_HUMAN
• UniProt AC: Q5VX52
• Protein Name: Spermatogenesis-associated protein 1
• Gene Name: SPATA1
• Organism: Homo sapiens (Human).
• Sequence Length: 459
• Protein Sequence: MKKDKKRNKIPIDNYPIQTLVNMSLNPSRPSSSELVELHVFYVPEGSWNYKLNTISTEVVNKFISAGFLRVSPQLTLRALRERLGEFLGEDAIAEKFLFLKCIGNNLAVVKEKQESELKLKSFAPPYALQPELYLLPVMDHLGNVYSPSTVILDERQTNNGVNEADGTIHRPISVTLFKEELGRDPSLLENTLKELPNKNQEEAGGKATAEKSQIAKNQIGNSELPGSLEDSNNDCFGTKKSQCLWENEDDTAISRRQDNQTAEKEYITLPDHPSLPCQPVLSSGITDISLLQTEREKIIKQMKQVKEERRYLERNREELVKTVEKLFEQSKLKRYHAYNGWKKKYLETKKVTASMEEVLTKLREDLELYYKKLLMQLEAREIKMRPKNLANITDSKNYLIIQITEVQHAIDQLKRKLDTDKMKLIVEVKMRKQAVSDLRTLKTELAQKKKIIHLYNLN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MKKDKKRNK ------CCCCCCCCC	36.53	-
10	Phosphorylation	KDKKRNKIPIDNYPI CCCCCCCCCCCCCCH	30.43	-
11	Phosphorylation	DKKRNKIPIDNYPIQ CCCCCCCCCCCCCHH	39.01	-
152	Phosphorylation	VYSPSTVILDERQTN CCCCCEEEECCHHHC	16.25	-
279	Ubiquitination	DHPSLPCQPVLSSGI CCCCCCCCCCCCCCC	48.06	32015554
309	Phosphorylation	QMKQVKEERRYLERN HHHHHHHHHHHHHHH	32.53	23909892
317	Phosphorylation	RRYLERNREELVKTV HHHHHHHHHHHHHHH	10.82	-
322	Ubiquitination	RNREELVKTVEKLFE HHHHHHHHHHHHHHH	39.89	-
323	Ubiquitination	NREELVKTVEKLFEQ HHHHHHHHHHHHHHH	51.87	-
331	Phosphorylation	VEKLFEQSKLKRYHA HHHHHHHHHHHHHHH	23.15	-
333	Phosphorylation	KLFEQSKLKRYHAYN HHHHHHHHHHHHHHC	19.84	-
333 (in isoform 4)	Phosphorylation	-	19.84	22496350
339	Phosphorylation	KLKRYHAYNGWKKKY HHHHHHHHCCCHHHH	32.96	-
355	Phosphorylation	ETKKVTASMEEVLTK HHHHCCCCHHHHHHH	35.80	-
383	Phosphorylation	MQLEAREIKMRPKNL HHHHHHHHCCCCCHH	17.46	-
415	Phosphorylation	QHAIDQLKRKLDTDK HHHHHHHHHHCCCCC	33.66	22985185
419	Phosphorylation	DQLKRKLDTDKMKLI HHHHHHCCCCCCHHE	39.65	22985185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPAT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPAT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPAT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBR4_HUMAN	UBR4	physical	26186194
SCYL2_HUMAN	SCYL2	physical	28514442
TLK2_HUMAN	TLK2	physical	28514442
TLK1_HUMAN	TLK1	physical	28514442
M3K4_HUMAN	MAP3K4	physical	28514442
WNK2_HUMAN	WNK2	physical	28514442
EST1A_HUMAN	SMG6	physical	28514442
WNK1_HUMAN	WNK1	physical	28514442
LRC49_HUMAN	LRRC49	physical	28514442
VPS39_HUMAN	VPS39	physical	28514442
WDCP_HUMAN	C2orf44	physical	28514442
NECP2_HUMAN	NECAP2	physical	28514442
KDM5C_HUMAN	KDM5C	physical	28514442
CMTR1_HUMAN	CMTR1	physical	28514442
EP300_HUMAN	EP300	physical	28514442
SREK1_HUMAN	SREK1	physical	28514442
CO039_HUMAN	C15orf39	physical	28514442
DHSO_HUMAN	SORD	physical	28514442
RFX1_HUMAN	RFX1	physical	28514442
PR40A_HUMAN	PRPF40A	physical	28514442
NECP1_HUMAN	NECAP1	physical	28514442
FWCH2_HUMAN	FLYWCH2	physical	28514442
P4R3B_HUMAN	SMEK2	physical	28514442
BICRA_HUMAN	GLTSCR1	physical	28514442
NUP58_HUMAN	NUPL1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.