CMTR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CMTR1_HUMAN
• UniProt AC: Q8N1G2
• Protein Name: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
• Gene Name: CMTR1
• Organism: Homo sapiens (Human).
• Sequence Length: 835
• Subcellular Localization: Nucleus .
• Protein Description: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway..
• Protein Sequence: MKRRTDPECTAPIKKQKKRVAELALSLSSTSDDEPPSSVSHGAKASTTSLSGSDSETEGKQHSSDSFDDAFKADSLVEGTSSRYSMYNSVSQKLMAKMGFREGEGLGKYSQGRKDIVEASSQKGRRGLGLTLRGFDQELNVDWRDEPEPSACEQVSWFPECTTEIPDTQEMSDWMVVGKRKMIIEDETEFCGEELLHSVLQCKSVFDVLDGEEMRRARTRANPYEMIRGVFFLNRAAMKMANMDFVFDRMFTNPRDSYGKPLVKDREAELLYFADVCAGPGGFSEYVLWRKKWHAKGFGMTLKGPNDFKLEDFYSASSELFEPYYGEGGIDGDGDITRPENISAFRNFVLDNTDRKGVHFLMADGGFSVEGQENLQEILSKQLLLCQFLMALSIVRTGGHFICKTFDLFTPFSVGLVYLLYCCFERVCLFKPITSRPANSERYVVCKGLKVGIDDVRDYLFAVNIKLNQLRNTDSDVNLVVPLEVIKGDHEFTDYMIRSNESHCSLQIKALAKIHAFVQDTTLSEPRQAEIRKECLRLWGIPDQARVAPSSSDPKSKFFELIQGTEIDIFSYKPTLLTSKTLEKIRPVFDYRCMVSGSEQKFLIGLGKSQIYTWDGRQSDRWIKLDLKTELPRDTLLSVEIVHELKGEGKAQRKISAIHILDVLVLNGTDVREQHFNQRIQLAEKFVKAVSKPSRPDMNPIRVKEVYRLEEMEKIFVRLEMKIIKGSSGTPKLSYTGRDDRHFVPMGLYIVRTVNEPWTMGFSKSFKKKFFYNKKTKDSTFDLPADSIAPFHICYYGRLFWEWGDGIRVHDSQKPQDQDKLSKEDVLSFIQMHRA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Methylation	----MKRRTDPECTA ----CCCCCCCCCCC		-
5	Phosphorylation	---MKRRTDPECTAP ---CCCCCCCCCCCC		28674419
5	O-linked_Glycosylation	---MKRRTDPECTAP ---CCCCCCCCCCCC		30620550
14	Acetylation	PECTAPIKKQKKRVA CCCCCCHHHHHHHHH		25953088
26	Phosphorylation	RVAELALSLSSTSDD HHHHHHHHHCCCCCC		23401153
28	Phosphorylation	AELALSLSSTSDDEP HHHHHHHCCCCCCCC		22167270
29	Phosphorylation	ELALSLSSTSDDEPP HHHHHHCCCCCCCCC		22167270
30	Phosphorylation	LALSLSSTSDDEPPS HHHHHCCCCCCCCCC		22167270
31	Phosphorylation	ALSLSSTSDDEPPSS HHHHCCCCCCCCCCC		22167270
37	Phosphorylation	TSDDEPPSSVSHGAK CCCCCCCCCCCCCCE		28176443
38	Phosphorylation	SDDEPPSSVSHGAKA CCCCCCCCCCCCCEE		28176443
40	Phosphorylation	DEPPSSVSHGAKAST CCCCCCCCCCCEEEC		23663014
46	Phosphorylation	VSHGAKASTTSLSGS CCCCCEEECCCCCCC		23927012
47	Phosphorylation	SHGAKASTTSLSGSD CCCCEEECCCCCCCC		23927012
48	Phosphorylation	HGAKASTTSLSGSDS CCCEEECCCCCCCCC		23927012
49	Phosphorylation	GAKASTTSLSGSDSE CCEEECCCCCCCCCC		25159151
51	Phosphorylation	KASTTSLSGSDSETE EEECCCCCCCCCCCC		29255136
53	Phosphorylation	STTSLSGSDSETEGK ECCCCCCCCCCCCCC		29255136
55	Phosphorylation	TSLSGSDSETEGKQH CCCCCCCCCCCCCCC		29255136
57	Phosphorylation	LSGSDSETEGKQHSS CCCCCCCCCCCCCCC		29255136
63	Phosphorylation	ETEGKQHSSDSFDDA CCCCCCCCCCCHHHH		29255136
64	Phosphorylation	TEGKQHSSDSFDDAF CCCCCCCCCCHHHHH		29255136
66	Phosphorylation	GKQHSSDSFDDAFKA CCCCCCCCHHHHHHH		29255136
72	Ubiquitination	DSFDDAFKADSLVEG CCHHHHHHHHHHCCC		29967540
75	Phosphorylation	DDAFKADSLVEGTSS HHHHHHHHHCCCCCH		29255136
80	Phosphorylation	ADSLVEGTSSRYSMY HHHHCCCCCHHHHHH		24275569
81	Phosphorylation	DSLVEGTSSRYSMYN HHHCCCCCHHHHHHH		25999147
82	Phosphorylation	SLVEGTSSRYSMYNS HHCCCCCHHHHHHHH		29255136
84	Phosphorylation	VEGTSSRYSMYNSVS CCCCCHHHHHHHHHH		28796482
85	Phosphorylation	EGTSSRYSMYNSVSQ CCCCHHHHHHHHHHH		28796482
87	Phosphorylation	TSSRYSMYNSVSQKL CCHHHHHHHHHHHHH		28796482
89	Phosphorylation	SRYSMYNSVSQKLMA HHHHHHHHHHHHHHH		28796482
91	Phosphorylation	YSMYNSVSQKLMAKM HHHHHHHHHHHHHHC		28796482
93	Ubiquitination	MYNSVSQKLMAKMGF HHHHHHHHHHHHCCC		32015554
93	Acetylation	MYNSVSQKLMAKMGF HHHHHHHHHHHHCCC		25953088
97	Ubiquitination	VSQKLMAKMGFREGE HHHHHHHHCCCCCCC		29967540
97	Acetylation	VSQKLMAKMGFREGE HHHHHHHHCCCCCCC		25953088
108	Ubiquitination	REGEGLGKYSQGRKD CCCCCCCCCCCCCHH		19608861
108	Acetylation	REGEGLGKYSQGRKD CCCCCCCCCCCCCHH		19608861
109	Phosphorylation	EGEGLGKYSQGRKDI CCCCCCCCCCCCHHH		-
110	Phosphorylation	GEGLGKYSQGRKDIV CCCCCCCCCCCHHHH		-
114	Ubiquitination	GKYSQGRKDIVEASS CCCCCCCHHHHHHHH		29967540
120	Phosphorylation	RKDIVEASSQKGRRG CHHHHHHHHHCCCCC		21815630
121	Phosphorylation	KDIVEASSQKGRRGL HHHHHHHHHCCCCCC		21406692
123	Ubiquitination	IVEASSQKGRRGLGL HHHHHHHCCCCCCCE		29967540
123	Acetylation	IVEASSQKGRRGLGL HHHHHHHCCCCCCCE		25953088
224	Phosphorylation	ARTRANPYEMIRGVF HHHHCCHHHHHHHHH		22817900
239	Ubiquitination	FLNRAAMKMANMDFV HHHHHHHHHCCCCHH		-
257	Phosphorylation	MFTNPRDSYGKPLVK CCCCCCCCCCCCCCC		28152594
258	Phosphorylation	FTNPRDSYGKPLVKD CCCCCCCCCCCCCCC		28152594
260	Ubiquitination	NPRDSYGKPLVKDRE CCCCCCCCCCCCCCC		-
260	Acetylation	NPRDSYGKPLVKDRE CCCCCCCCCCCCCCC		26051181
272	Phosphorylation	DREAELLYFADVCAG CCCHHHHEEEEECCC		-
301	Phosphorylation	HAKGFGMTLKGPNDF CCCCCCCCCCCCCCC		25278378
303	Ubiquitination	KGFGMTLKGPNDFKL CCCCCCCCCCCCCCH		29967540
343	Phosphorylation	ITRPENISAFRNFVL CCCCCHHHHHHCEEC		24719451
393	Phosphorylation	CQFLMALSIVRTGGH HHHHHHHHHHHHCCC		24719451
405	Phosphorylation	GGHFICKTFDLFTPF CCCEEEECCCCCCCH		-
447	Ubiquitination	SERYVVCKGLKVGID CCCEEEECCEEECHH		22505724
450	Ubiquitination	YVVCKGLKVGIDDVR EEEECCEEECHHHHH		29967540
487	Ubiquitination	VVPLEVIKGDHEFTD EEEEEEEECCCCCHH		29967540
509	Ubiquitination	SHCSLQIKALAKIHA CCHHHHHHHHHHHHH		29967540
513	Ubiquitination	LQIKALAKIHAFVQD HHHHHHHHHHHHHCC		29967540
537	Methylation	EIRKECLRLWGIPDQ HHHHHHHHHHCCCCC		-
550	Phosphorylation	DQARVAPSSSDPKSK CCCCCCCCCCCCHHH		30576142
551	Phosphorylation	QARVAPSSSDPKSKF CCCCCCCCCCCHHHH		20068231
552	Phosphorylation	ARVAPSSSDPKSKFF CCCCCCCCCCHHHHH		20068231
555	Ubiquitination	APSSSDPKSKFFELI CCCCCCCHHHHHHHH		29967540
584	Acetylation	LTSKTLEKIRPVFDY CCCCCHHHHHCCCCE		23236377
584	Ubiquitination	LTSKTLEKIRPVFDY CCCCCHHHHHCCCCE		29967540
608	Ubiquitination	KFLIGLGKSQIYTWD EEEEEECCCEEEECC		22505724
624	Ubiquitination	RQSDRWIKLDLKTEL CCCCEEEEEEECCCC		29967540
685	Ubiquitination	QRIQLAEKFVKAVSK HHHHHHHHHHHHHCC		-
685	Acetylation	QRIQLAEKFVKAVSK HHHHHHHHHHHHHCC		25953088
692	Ubiquitination	KFVKAVSKPSRPDMN HHHHHHCCCCCCCCC		29967540
694	Phosphorylation	VKAVSKPSRPDMNPI HHHHCCCCCCCCCCC		19664995
704	Ubiquitination	DMNPIRVKEVYRLEE CCCCCCCEEEEEHHH		-
707	Phosphorylation	PIRVKEVYRLEEMEK CCCCEEEEEHHHHHH		-
714	Ubiquitination	YRLEEMEKIFVRLEM EEHHHHHHHHHEEEE		-
722	Ubiquitination	IFVRLEMKIIKGSSG HHHEEEEEEEECCCC		-
725	Ubiquitination	RLEMKIIKGSSGTPK EEEEEEEECCCCCCC		29967540
727	Phosphorylation	EMKIIKGSSGTPKLS EEEEEECCCCCCCCC		26425664
728	Phosphorylation	MKIIKGSSGTPKLSY EEEEECCCCCCCCCC		26270265
730	Phosphorylation	IIKGSSGTPKLSYTG EEECCCCCCCCCCCC		26270265
732	Ubiquitination	KGSSGTPKLSYTGRD ECCCCCCCCCCCCCC		29967540
764	Ubiquitination	PWTMGFSKSFKKKFF CCCCCCCHHHHHHHC		-
765	Phosphorylation	WTMGFSKSFKKKFFY CCCCCCHHHHHHHCC		-
767	Ubiquitination	MGFSKSFKKKFFYNK CCCCHHHHHHHCCCC		-
774	Ubiquitination	KKKFFYNKKTKDSTF HHHHCCCCCCCCCCC		-
777	Ubiquitination	FFYNKKTKDSTFDLP HCCCCCCCCCCCCCC		-
787	Phosphorylation	TFDLPADSIAPFHIC CCCCCHHHCCCEEEE		29083192
795	Phosphorylation	IAPFHICYYGRLFWE CCCEEEEEEEEECEE		29083192
796	Phosphorylation	APFHICYYGRLFWEW CCEEEEEEEEECEEC		29083192
820	Ubiquitination	QKPQDQDKLSKEDVL CCCCCCCCCCHHHHH		23000965
823	Ubiquitination	QDQDKLSKEDVLSFI CCCCCCCHHHHHHHH		21890473
823	Ubiquitination	QDQDKLSKEDVLSFI CCCCCCCHHHHHHHH		23000965

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CMTR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CMTR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CMTR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYIC_HUMAN	IARS	physical	26344197
BRE1A_HUMAN	RNF20	physical	26344197
BRE1B_HUMAN	RNF40	physical	26344197
SETD3_HUMAN	SETD3	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.