RNF43_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RNF43_HUMAN
• UniProt AC: Q68DV7
• Protein Name: E3 ubiquitin-protein ligase RNF43
• Gene Name: RNF43
• Organism: Homo sapiens (Human).
• Sequence Length: 783
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope. According to a report, may be secreted.
• Protein Description: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone..
• Protein Sequence: MSGGHQLQLAALWPWLLMATLQAGFGRTGLVLAAAVESERSAEQKAIIRVIPLKMDPTGKLNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQPLGLTWPVVLIWGNDAEKLMEFVYKNQKAHVRIELKEPPAWPDYDVWILMTVVGTIFVIILASVLRIRCRPRHSRPDPLQQRTAWAISQLATRRYQASCRQARGEWPDSGSSCSSAPVCAICLEEFSEGQELRVISCLHEFHRNCVDPWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGRRLHLIRQHPGHAHYHLPAAYLLGPSRSAVARPPRPGPFLPSQEPGMGPRHHRFPRAAHPRAPGEQQRLAGAQHPYAQGWGLSHLQSTSQHPAACPVPLRRARPPDSSGSGESYCTERSGYLADGPASDSSSGPCHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLVYCSPKGDPQRVDMQPSVTSRPRSLDSVVPTGETQVSSHVHYHRHRHHHYKKRFQWHGRKPGPETGVPQSRPPIPRTQPQPEPPSPDQQVTRSNSAAPSGRLSNPQCPRALPEPAPGPVDASSICPSTSSLFNLQKSSLSARHPQRKRRGGPSEPTPGSRPQDATVHPACQIFPHYTPSVAYPWSPEAHPLICGPPGLDKRLLPETPGPCYSNSQPVWLCLTPRQPLEPHPPGEGPSEWSSDTAEGRPCPYPHCQVLSAQPGSEEELEELCEQAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGGHQLQL ------CCCHHHHHH	54.18	24043423
20	Phosphorylation	WPWLLMATLQAGFGR HHHHHHHHHHHCCCC	12.87	24043423
62	N-linked_Glycosylation	MDPTGKLNLTLEGVF CCCCCCCEEEEEEEE	34.17	UniProtKB CARBOHYD
92	N-linked_Glycosylation	SHPLYLCNASDDDNL CCCEEEECCCCCCCC	39.62	UniProtKB CARBOHYD
105	Phosphorylation	NLEPGFISIVKLESP CCCCCEEEEEECCCC	21.04	24719451
121	Phosphorylation	RAPRPCLSLASKARM CCCCCHHHHHHHHHH	28.71	20860994
329	Phosphorylation	FSQSLGPSRSYQEPG HHHHCCCCCCCCCCC	31.87	24719451
364	Phosphorylation	YLLGPSRSAVARPPR HHHCCCHHHCCCCCC	31.28	22210691
585	Phosphorylation	SRPPIPRTQPQPEPP CCCCCCCCCCCCCCC	38.97	-
593	Phosphorylation	QPQPEPPSPDQQVTR CCCCCCCCCCCCCCC	52.39	28348404
667	Phosphorylation	PSEPTPGSRPQDATV CCCCCCCCCCCCCEE	41.83	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RNF43	Q68DV7	PMID:18313049

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RNF43_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RNF43_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AKP8L_HUMAN	AKAP8L	physical	18313049
HECW1_HUMAN	HECW1	physical	21108931
P53_HUMAN	TP53	physical	21108931
SFPQ_HUMAN	SFPQ	physical	18655028
NONO_HUMAN	NONO	physical	18655028
RSPO1_HUMAN	RSPO1	physical	23756651
RNF43_HUMAN	RNF43	physical	18313049
UB2D2_HUMAN	UBE2D2	physical	18313049
UB2D3_HUMAN	UBE2D3	physical	18313049
DVL2_HUMAN	DVL2	physical	25891077
FZD5_HUMAN	FZD5	physical	25825523
DVL2_HUMAN	DVL2	physical	25825523
MYADM_HUMAN	MYADM	physical	28514442
KC1E_HUMAN	CSNK1E	physical	28514442
CSK21_HUMAN	CSNK2A1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.