CDHR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDHR1_HUMAN
• UniProt AC: Q96JP9
• Protein Name: Cadherin-related family member 1
• Gene Name: CDHR1
• Organism: Homo sapiens (Human).
• Sequence Length: 859
• Subcellular Localization: Cell membrane; Single-pass membrane protein. Localized at the junction between the inner and outer segments of rod and cone photoreceptors cells. Confined to the base of the OS. Localized on the edges of nascent evaginating disks on the side of the O
• Protein Description: Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity)..
• Protein Sequence: MRRCRWAALALGLLRLCLAQANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITDAETLSRSPMAAFLIQTKDNPMKAVGVLAGTMATVVAITVLISTATFWRNKKSNKVLPMRRVLRKRPSPAPRTIRIEWLKSKSTKAATKFMLKEKPPNENCNNNSPESSLLPRAPALPPPPSVAPSTGAAQWTVPTVSGSLTPQPTQPPPKPKTMGSPVQSTLISELKQKFEKKSVHNKAYF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	N-linked_Glycosylation	GSHVYTLNGTDPEGD CEEEEEECCCCCCCC	43.44	UniProtKB CARBOHYD
89	N-linked_Glycosylation	SVDPTFGNITLVEEL EECCCCCCEEEEEEH	21.63	UniProtKB CARBOHYD
296	N-linked_Glycosylation	NDGAFEINETSGAIS CCCEEEECCCCCCEE	39.02	UniProtKB CARBOHYD
298	Phosphorylation	GAFEINETSGAISIT CEEEECCCCCCEEEE	28.15	22468782
299	Phosphorylation	AFEINETSGAISITQ EEEECCCCCCEEEEC	21.76	22468782
303	Phosphorylation	NETSGAISITQSPAQ CCCCCCEEEECCHHH	21.03	22468782
665	Phosphorylation	AKDRGSPSFSTTALL ECCCCCCCCCEEEEE	33.26	-
665 (in isoform 2)	Phosphorylation	-	33.26	-
667	Phosphorylation	DRGSPSFSTTALLKI CCCCCCCCEEEEEEE	29.23	22210691
668 (in isoform 2)	Phosphorylation	-	17.68	-
668	Phosphorylation	RGSPSFSTTALLKID CCCCCCCEEEEEEEE	17.68	22210691
711	Phosphorylation	VLAGTMATVVAITVL HHHHHHHHHHHHHHH	12.51	25332170
716	Phosphorylation	MATVVAITVLISTAT HHHHHHHHHHHHHHH	10.26	25332170
720	Phosphorylation	VAITVLISTATFWRN HHHHHHHHHHHHHCC	14.08	25332170
721	Phosphorylation	AITVLISTATFWRNK HHHHHHHHHHHHCCC	23.79	25332170
723	Phosphorylation	TVLISTATFWRNKKS HHHHHHHHHHCCCCC	24.66	25332170
745	Phosphorylation	RVLRKRPSPAPRTIR HHHHCCCCCCCCEEE	37.41	-
831	Phosphorylation	QPPPKPKTMGSPVQS CCCCCCCCCCCCHHH	34.98	26270265
834	Phosphorylation	PKPKTMGSPVQSTLI CCCCCCCCCHHHHHH	15.86	26270265
838	Phosphorylation	TMGSPVQSTLISELK CCCCCHHHHHHHHHH	25.97	26270265
839	Phosphorylation	MGSPVQSTLISELKQ CCCCHHHHHHHHHHH	15.83	26270265
842	Phosphorylation	PVQSTLISELKQKFE CHHHHHHHHHHHHHH	39.73	26270265

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDHR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDHR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDHR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PROM1_HUMAN	PROM1	physical	18654668

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.