dbPTM

WASF3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WASF3_HUMAN
UniProt AC	Q9UPY6
Protein Name	Wiskott-Aldrich syndrome protein family member 3
Gene Name	WASF3
Organism	Homo sapiens (Human).
Sequence Length	502
Subcellular Localization	Cytoplasm, cytoskeleton.
Protein Description	Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape..
Protein Sequence	MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEANNFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNPVADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQKEQKRIDGTTREVKKVRKARNRRQEWNMMAYDKELRPDNRLSQSVYHGASSEGSLSPDTRSHASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPASQAAEHEYRPPSASARHMALNRPQQPPPPPPPQAPEGSQASAPMAPADYGMLPAQIIEYYNPSGPPPPPPPPVIPSAQTAFVSPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPPGPGSSLSSSPMHGPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVGNDVATILSRRIAVEYSDSDDDSEFDENDWSD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
151	Phosphorylation	KKDGLKFYTDPSYFF CCCCCCCCCCHHHHH	14.51	19060867
156	Phosphorylation	KFYTDPSYFFDLWKE CCCCCHHHHHHHHHH	17.41	20736484
162	Ubiquitination	SYFFDLWKEKMLQDT HHHHHHHHHHHCCCH	55.54	-
162	Ubiquitination	SYFFDLWKEKMLQDT HHHHHHHHHHHCCCH	55.54	2190698
169	Phosphorylation	KEKMLQDTEDKRKEK HHHHCCCHHHHHHHH	32.87	23684312
221	Phosphorylation	LRPDNRLSQSVYHGA CCCCCCCCCCHHCCC	19.71	26356563
223	Phosphorylation	PDNRLSQSVYHGASS CCCCCCCCHHCCCCC	22.67	25884760
225	Phosphorylation	NRLSQSVYHGASSEG CCCCCCHHCCCCCCC	10.36	25884760
229	Phosphorylation	QSVYHGASSEGSLSP CCHHCCCCCCCCCCC	33.25	26356563
230	Phosphorylation	SVYHGASSEGSLSPD CHHCCCCCCCCCCCC	45.50	26356563
233	Phosphorylation	HGASSEGSLSPDTRS CCCCCCCCCCCCCCC	22.94	26356563
235	Phosphorylation	ASSEGSLSPDTRSHA CCCCCCCCCCCCCCC	23.56	28450419
238	Phosphorylation	EGSLSPDTRSHASDV CCCCCCCCCCCCCCC	37.14	28450419
246	Phosphorylation	RSHASDVTDYSYPAT CCCCCCCCCCCCCCC	33.92	-
248	Phosphorylation	HASDVTDYSYPATPN CCCCCCCCCCCCCCC	10.76	25884760
286	Phosphorylation	SQAAEHEYRPPSASA HHHHCCCCCCCCHHH	30.26	25884760
337	Phosphorylation	LPAQIIEYYNPSGPP CCHHHHHHCCCCCCC	9.72	17623672
479	Phosphorylation	NDVATILSRRIAVEY HHHHHHHHCEEEEEE	18.70	16275905
486	Phosphorylation	SRRIAVEYSDSDDDS HCEEEEEECCCCCCC	15.92	15489334

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
151	Y	Phosphorylation	Kinase	ABL	P00519	PSP
248	Y	Phosphorylation	Kinase	ABL	P00519	PSP
337	Y	Phosphorylation	Kinase	ABL	P00519	PSP
486	Y	Phosphorylation	Kinase	ABL	P00519	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WASF3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WASF3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARP3_HUMAN	ACTR3	physical	10381382
ABI1_HUMAN	ABI1	physical	28514442
NCKP1_HUMAN	NCKAP1	physical	28514442
GT2D1_HUMAN	GTF2IRD1	physical	28514442
BRK1_HUMAN	BRK1	physical	28514442
CMTR1_HUMAN	CMTR1	physical	28514442
CYFP2_HUMAN	CYFIP2	physical	28514442
HXB9_HUMAN	HOXB9	physical	28514442
NHRF2_HUMAN	SLC9A3R2	physical	28514442
CYFP1_HUMAN	CYFIP1	physical	28514442
LPP_HUMAN	LPP	physical	28514442
CD47_HUMAN	CD47	physical	28514442
F10C1_HUMAN	FRA10AC1	physical	28514442
CENPF_HUMAN	CENPF	physical	28514442
SUV3_HUMAN	SUPV3L1	physical	28514442
SKT_HUMAN	KIAA1217	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WASF3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodiaformation and cell migration."; Sossey-Alaoui K., Li X., Cowell J.K.; J. Biol. Chem. 282:26257-26265(2007). Cited for: FUNCTION, AND PHOSPHORYLATION AT TYR-151; TYR-248; TYR-337 ANDTYR-486.	17623672 [Abstract]