PCD16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCD16_HUMAN
• UniProt AC: Q96JQ0
• Protein Name: Protocadherin-16
• Gene Name: DCHS1
• Organism: Homo sapiens (Human).
• Sequence Length: 3298
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein. In the embryonic cortex, FAT4 and DCHS1 accumulated at the cell-cell boundaries located apical to the adherens junction..
• Protein Description: Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation. [PubMed: 26258302]
• Protein Sequence: MQKELGIVPSCPGMKSPRPHLLLPLLLLLLLLLGAGVPGAWGQAGSLDLQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQRDRYRFTAVTPDGATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYLRVDSRAPGSGTATSGGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTVDITHTALGLAPDLNLLLVGAVAASLGVVVVLALAALVLGLVRARSRKAEAAPGPMSQAAPLASDSLQKLGREPPSPPPSEHLYHQTLPSYGGPGAGGPYPRGGSLDPSHSSGRGSAEAAEDDEIRMINEFPRVASVASSLAARGPDSGIQQDADGLSDTSCEPPAPDTWYKGRKAGLLLPGAGATLYREEGPPATATAFLGGCGLSPAPTGDYGFPADGKPCVAGALTAIVAGEEELRGSYNWDYLLSWCPQFQPLASVFTEIARLKDEARPCPPAPRIDPPPLITAVAHPGAKSVPPKPANTAAARAIFPPASHRSPISHEGSLSSAAMSPSFSPSLSPLAARSPVVSPFGVAQGPSASALSAESGLEPPDDTELHI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
156	Phosphorylation	ALQVPEHTAFGTRYP HHCCCCCCCCCCCCC	23.24	30108239
160	Phosphorylation	PEHTAFGTRYPLEPA CCCCCCCCCCCCCCC	22.15	30108239
162	Phosphorylation	HTAFGTRYPLEPARD CCCCCCCCCCCCCCC	16.41	30108239
217	N-linked_Glycosylation	TGELDRENRSHYMLQ ECCCCCCCCCEEEEE	52.20	UniProtKB CARBOHYD
256	N-linked_Glycosylation	NDHAPAFNQSRYHAV CCCCCCCCCCCCEEE	40.81	UniProtKB CARBOHYD
402	N-linked_Glycosylation	DGDFAHVNVSLEGGE CCCEEEEEEEEECCC	14.06	UniProtKB CARBOHYD
438	Phosphorylation	DREERDAYNLRVTAT CHHHHHHCCCEEEEC	21.01	22817900
584	N-linked_Glycosylation	QFQRTFYNASLPEGT CHHHEEEECCCCCCC	20.89	UniProtKB CARBOHYD
591	O-linked_Glycosylation	NASLPEGTQPGTCFL ECCCCCCCCCCCEEE	29.90	OGP
915	Phosphorylation	APGTPIYTLRALDPD CCCCCEEEEEECCCC	15.53	24719451
942	Phosphorylation	AGGGGAFTVDPTTGH ECCCCCEEECCCCCC	24.38	-
946	Phosphorylation	GAFTVDPTTGHVRLM CCEEECCCCCCEEEE	40.73	-
947	Phosphorylation	AFTVDPTTGHVRLMR CEEECCCCCCEEEEE	30.58	-
1002	Phosphorylation	GLAPRFNSPTYRVDL CCCCCCCCCEEEEEC	18.86	23403867
1004	Phosphorylation	APRFNSPTYRVDLPS CCCCCCCEEEEECCC	24.63	23403867
1005	Phosphorylation	PRFNSPTYRVDLPSG CCCCCCEEEEECCCC	16.42	23403867
1076	Phosphorylation	ILKVMAVSGSKAELG EEEEEEECCCHHHHC	28.01	-
1078	Phosphorylation	KVMAVSGSKAELGQQ EEEEECCCHHHHCCC	22.61	-
1168	Phosphorylation	GEVTTLQTLDREQQS CCEEEEEECCHHHHC	33.47	-
1196	Phosphorylation	PPRSTTGTVHVAVLD CCCCCCCEEEEEEEE	12.83	-
1208	Phosphorylation	VLDLNDNSPTFLQAS EEECCCCCCCCCEEC	28.34	-
1210	Phosphorylation	DLNDNSPTFLQASGA ECCCCCCCCCEECCC	36.48	-
1234	Phosphorylation	PDRVPPGTLVTTLQA CCCCCCCCEEEEEEE	24.67	-
1237	Phosphorylation	VPPGTLVTTLQAKDP CCCCCEEEEEEECCC	25.54	-
1238	Phosphorylation	PPGTLVTTLQAKDPD CCCCEEEEEEECCCC	14.92	-
1249	N-linked_Glycosylation	KDPDEGENGTILYTL CCCCCCCCCEEEEEE	64.86	UniProtKB CARBOHYD
1290	Phosphorylation	ERPHYVLTLSAHDQG CCCCEEEEEEECCCC	14.50	30206219
1292	Phosphorylation	PHYVLTLSAHDQGSP CCEEEEEEECCCCCC	20.51	30206219
1298	Phosphorylation	LSAHDQGSPPRSASL EEECCCCCCCCCHHH	26.54	30206219
1496	Phosphorylation	DARTGALSAPRGLDR ECCCCCCCCCCCCCC	35.38	24719451
1521	N-linked_Glycosylation	EATDRPANASRRRAA HHCCCCCCHHHHHHH	40.92	UniProtKB CARBOHYD
1581	Phosphorylation	LGEAARVSYRLASGG HHHHHHEEEEECCCC	10.05	23828894
1582	Phosphorylation	GEAARVSYRLASGGD HHHHHEEEEECCCCC	13.54	-
1586	Phosphorylation	RVSYRLASGGDGHFR HEEEEECCCCCCCEE	48.15	-
1593	Methylation	SGGDGHFRLHSSTGA CCCCCCEEEECCCCC	26.30	-
1718	N-linked_Glycosylation	REEQEEINLTVYAQD HHHHHCCCEEEEECC	32.70	UniProtKB CARBOHYD
1959	Phosphorylation	DVNDHAPTFPTSPLR ECCCCCCCCCCCCCE	42.93	29083192
1962	Phosphorylation	DHAPTFPTSPLRLRL CCCCCCCCCCCEECC	38.49	29083192
1963	Phosphorylation	HAPTFPTSPLRLRLP CCCCCCCCCCEECCC	23.36	29083192
1996	N-linked_Glycosylation	EDRDAGANASILYRL HHCCCCCCCEEEHHH	33.05	UniProtKB CARBOHYD
1998	Phosphorylation	RDAGANASILYRLAG CCCCCCCEEEHHHHC	16.97	24905233
2001	Phosphorylation	GANASILYRLAGTPP CCCCEEEHHHHCCCC	11.25	24905233
2006	Phosphorylation	ILYRLAGTPPPGTTV EEHHHHCCCCCCCCC	27.32	24905233
2011	Phosphorylation	AGTPPPGTTVDSYTG HCCCCCCCCCCCCCC	29.44	24905233
2012	Phosphorylation	GTPPPGTTVDSYTGE CCCCCCCCCCCCCCE	28.38	24905233
2015	Phosphorylation	PPGTTVDSYTGEIRV CCCCCCCCCCCEEEE	21.91	24905233
2016	Phosphorylation	PGTTVDSYTGEIRVA CCCCCCCCCCEEEEE	17.82	24905233
2017	Phosphorylation	GTTVDSYTGEIRVAR CCCCCCCCCEEEEEC	32.08	24905233
2049	Phosphorylation	DLGRPARSATGVIIV CCCCCCCCCCEEEEE	32.08	24719451
2361	N-linked_Glycosylation	GPHEGRANLTVLVED CCCCCCCEEEEEEEE	34.58	UniProtKB CARBOHYD
2363	Phosphorylation	HEGRANLTVLVEDVN CCCCCEEEEEEEECC	16.17	24043423
2377	Phosphorylation	NDNAPAFSQSLYQVM CCCCHHHHHHHHHHH	22.44	24043423
2379	Phosphorylation	NAPAFSQSLYQVMLL CCHHHHHHHHHHHCC	28.04	24043423
2381	Phosphorylation	PAFSQSLYQVMLLEH HHHHHHHHHHHCCCC	12.33	24043423
2389	Phosphorylation	QVMLLEHTPPGSAIL HHHCCCCCCCCCEEE	23.08	24043423
2393	Phosphorylation	LEHTPPGSAILSVSA CCCCCCCCEEEEEEE	20.22	24043423
2397	Phosphorylation	PPGSAILSVSATDRD CCCCEEEEEEEECCC	14.12	24043423
2399	Phosphorylation	GSAILSVSATDRDSG CCEEEEEEEECCCCC	23.29	24043423
2401	Phosphorylation	AILSVSATDRDSGAN EEEEEEEECCCCCCC	24.86	24043423
2428	N-linked_Glycosylation	GFSVDPNNGTLFTIV CCEECCCCCCEEEEE	50.65	UniProtKB CARBOHYD
2512	Phosphorylation	EATDADGSRSHAAVD EEECCCCCCCCEEEE	31.02	23403867
2514	Phosphorylation	TDADGSRSHAAVDYS ECCCCCCCCEEEEEE	21.12	23403867
2521	Phosphorylation	SHAAVDYSIISGNWG CCEEEEEEEECCCCC	14.69	23403867
2524	Phosphorylation	AVDYSIISGNWGRVF EEEEEEECCCCCEEE	25.14	23403867
2569	N-linked_Glycosylation	FESLTQYNLTVAAAD HHHHHCCEEEEEEHH	21.30	UniProtKB CARBOHYD
2761	N-linked_Glycosylation	GREAFALNSSTGELR HHEEEEECCCCCCEE	30.41	UniProtKB CARBOHYD
2792	N-linked_Glycosylation	VGAADAGNLSASVTV EEHHCCCCCCEEEEE	32.32	UniProtKB CARBOHYD
2862	N-linked_Glycosylation	SSPYFGINQTTGALY CCCCCCCCCCCCEEE	33.26	UniProtKB CARBOHYD
2967	Ubiquitination	LVRARSRKAEAAPGP HHHHHHCCCCCCCCC	52.40	32142685
2976	Phosphorylation	EAAPGPMSQAAPLAS CCCCCCHHHHHHHCC	21.57	22210691
2983	Phosphorylation	SQAAPLASDSLQKLG HHHHHHCCHHHHHCC	35.10	30266825
2985	Phosphorylation	AAPLASDSLQKLGRE HHHHCCHHHHHCCCC	30.15	30266825
2988	Ubiquitination	LASDSLQKLGREPPS HCCHHHHHCCCCCCC	59.19	32142685
2995	Phosphorylation	KLGREPPSPPPSEHL HCCCCCCCCCCCHHH	61.83	24719451
2999	Phosphorylation	EPPSPPPSEHLYHQT CCCCCCCCHHHCCCC	43.34	25002506
3003	Phosphorylation	PPPSEHLYHQTLPSY CCCCHHHCCCCCCCC	8.19	25002506
3006	Phosphorylation	SEHLYHQTLPSYGGP CHHHCCCCCCCCCCC	27.59	25002506
3009	Phosphorylation	LYHQTLPSYGGPGAG HCCCCCCCCCCCCCC	39.25	25884760
3010	Phosphorylation	YHQTLPSYGGPGAGG CCCCCCCCCCCCCCC	24.94	28348404
3024	Phosphorylation	GPYPRGGSLDPSHSS CCCCCCCCCCCCCCC	32.21	26699800
3028	Phosphorylation	RGGSLDPSHSSGRGS CCCCCCCCCCCCCCC	35.35	26699800
3030	Phosphorylation	GSLDPSHSSGRGSAE CCCCCCCCCCCCCCC	38.53	26699800
3031	Phosphorylation	SLDPSHSSGRGSAEA CCCCCCCCCCCCCCH	27.38	26699800
3035	Phosphorylation	SHSSGRGSAEAAEDD CCCCCCCCCCHHCCH	22.90	26699800
3055	Phosphorylation	NEFPRVASVASSLAA CCCHHHHHHHHHHHH	18.50	30266825
3058	Phosphorylation	PRVASVASSLAARGP HHHHHHHHHHHHHCC	24.59	30266825
3059	Phosphorylation	RVASVASSLAARGPD HHHHHHHHHHHHCCC	16.58	30266825
3094	Ubiquitination	DTWYKGRKAGLLLPG CCCCCCCEEEEEECC	56.31	32142685
3107	Phosphorylation	PGAGATLYREEGPPA CCCCCEEECCCCCCC	16.18	25884760
3237	Phosphorylation	FPPASHRSPISHEGS CCCCCCCCCCCCCCC	22.59	27732954
3240	Phosphorylation	ASHRSPISHEGSLSS CCCCCCCCCCCCCCC	20.90	27732954
3244	Phosphorylation	SPISHEGSLSSAAMS CCCCCCCCCCCCCCC	23.30	27732954
3246	Phosphorylation	ISHEGSLSSAAMSPS CCCCCCCCCCCCCCC	21.45	27732954
3247	Phosphorylation	SHEGSLSSAAMSPSF CCCCCCCCCCCCCCC	25.91	27732954
3251	Phosphorylation	SLSSAAMSPSFSPSL CCCCCCCCCCCCCCC	16.80	27732954
3253	Phosphorylation	SSAAMSPSFSPSLSP CCCCCCCCCCCCCCH	30.92	27732954
3255	Phosphorylation	AAMSPSFSPSLSPLA CCCCCCCCCCCCHHH	20.23	27732954
3257	Phosphorylation	MSPSFSPSLSPLAAR CCCCCCCCCCHHHHC	40.04	27732954
3259	Phosphorylation	PSFSPSLSPLAARSP CCCCCCCCHHHHCCC	23.39	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCD16_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCD16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCD16_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PCD16_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 601390: Van Maldergem syndrome 1 (VMLDS1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.