PCDH9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCDH9_HUMAN
• UniProt AC: Q9HC56
• Protein Name: Protocadherin-9
• Gene Name: PCDH9
• Organism: Homo sapiens (Human).
• Sequence Length: 1237
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Potential calcium-dependent cell-adhesion protein..
• Protein Sequence: MDLRDFYLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVLVRCRHASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKRKSPKSSLLNFVTIEESKPDDAVHEPINGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKKHHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECSSQGGFKTKGPLHTRQCNSHSKSDNIPVTPQKCPSSTGFHIQENEESHYESQRRVTFHLPDGSQESCSDSGLGDHEPVGSGTLISHPLPLVQPQDEFYDQASPDKRTEADGNSDPNSDGPLGPRGLAEATEMCTQECLVLGHSDNCWMPPGLGPYQHPKSPLSTFAPQKEWVKKDKLVNGHTLTRAWKEDSNRNQFNDRKQYGSNEGHFNNGSHMTDIPLANLKSYKQAGGATESPKEHQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	IAQELIYTIREELPE HHHHHHHHHHHHCCC	13.43	24719451
48	N-linked_Glycosylation	GNIPKDLNISHINAA CCCCCCCCCCEEECC	43.80	UniProtKB CARBOHYD
56	O-linked_Glycosylation	ISHINAATGTSASLV CCEEECCCCCCHHHH	38.28	OGP
58	O-linked_Glycosylation	HINAATGTSASLVYR EEECCCCCCHHHHHH	19.43	OGP
148	N-linked_Glycosylation	MFPSPVINISIPENT CCCCCCEEEECCCCC	23.37	UniProtKB CARBOHYD
217	Phosphorylation	LDREQKDTYVMKIKV CCHHHCCEEEEEEEE	25.67	30206219
218	Phosphorylation	DREQKDTYVMKIKVE CHHHCCEEEEEEEEC	14.53	30206219
229	Phosphorylation	IKVEDGGTPQKSSTA EEECCCCCCCCCCEE	28.24	29083192
233	Phosphorylation	DGGTPQKSSTAILQV CCCCCCCCCEEEEEE	27.89	-
306	N-linked_Glycosylation	TKRLFALNNTTGLIT CCEEEECCCCCCEEE	40.13	UniProtKB CARBOHYD
307	N-linked_Glycosylation	KRLFALNNTTGLITV CEEEECCCCCCEEEE	39.61	UniProtKB CARBOHYD
323	Phosphorylation	RSLDREETAIHKVTV CCCCCHHCEEEEEEE	26.59	29396449
347	N-linked_Glycosylation	ARATVTINVTDVNDN CEEEEEEEEEECCCC	22.67	UniProtKB CARBOHYD
365	Phosphorylation	IDLRYIISPINGTVY EEEEEEEECCCCEEE	15.35	24719451
368	N-linked_Glycosylation	RYIISPINGTVYLSE EEEEECCCCEEEECC	43.39	UniProtKB CARBOHYD
436	Phosphorylation	YEGTKEFSFKIVASD CCCCCEEEEEEEECC	27.07	24719451
450	N-linked_Glycosylation	DSGKPSLNQTALVRV CCCCCCCCCEEEEEE	41.30	UniProtKB CARBOHYD
489	Phosphorylation	NRRGLYLTTISATDE CCCEEEEEEEEEECC	14.45	28985074
490	Phosphorylation	RRGLYLTTISATDED CCEEEEEEEEEECCC	15.44	28985074
494	Phosphorylation	YLTTISATDEDSGKN EEEEEEEECCCCCCC	32.88	28985074
511	N-linked_Glycosylation	IVYQLGPNASFFDLD EEEECCCCCEEEECC	46.55	UniProtKB CARBOHYD
525	Phosphorylation	DRKTGVLTASRVFDR CCCCCEEEEEEECCH	21.85	-
527	Phosphorylation	KTGVLTASRVFDREE CCCEEEEEEECCHHH	24.60	-
549	Phosphorylation	VTARDNGTPPLQSQA EEECCCCCCCCCCEE	28.17	-
589	Phosphorylation	SENLPKYSTVGVITV ECCCCCCCEEEEEEE	23.81	-
590	Phosphorylation	ENLPKYSTVGVITVT CCCCCCCEEEEEEEE	20.42	-
595	Phosphorylation	YSTVGVITVTDADAG CCEEEEEEEEECCCC	18.23	-
630	N-linked_Glycosylation	YSGVIKSNVSFDREQ CCCEEEECCCCCCCC	28.57	UniProtKB CARBOHYD
681	N-linked_Glycosylation	VVISPPSNTSFKLVP EEECCCCCCCEEEEE	45.58	UniProtKB CARBOHYD
734	N-linked_Glycosylation	RIDPVTGNITLEEKP EEECCCCCEEECCCC	18.08	UniProtKB CARBOHYD
754	N-linked_Glycosylation	GLHRLVVNISDLGYP CCCEEEEEHHHCCCC	22.14	UniProtKB CARBOHYD
775	N-linked_Glycosylation	VLVFLYVNDTAGNAS EEEEEEECCCCCCHH	27.62	UniProtKB CARBOHYD
780	N-linked_Glycosylation	YVNDTAGNASYIYDL EECCCCCCHHHHHHH	24.21	UniProtKB CARBOHYD
791	Phosphorylation	IYDLIRRTMETPLDR HHHHHHHHCCCCCCC	14.98	26074081
794	Phosphorylation	LIRRTMETPLDRNIG HHHHHCCCCCCCCCC	20.52	26074081
851	Ubiquitination	FKAAQRSKQGAEWMS HHHHHHHHCCCCCCC	55.74	-
879	Phosphorylation	KKRKSPKSSLLNFVT HHCCCCCHHHHCCEE	29.60	24275569
926	Phosphorylation	DWGPAPPTTFKPNSP CCCCCCCCCCCCCCH	43.75	25850435
927	Phosphorylation	WGPAPPTTFKPNSPD CCCCCCCCCCCCCHH	35.12	25850435
932	Phosphorylation	PTTFKPNSPDLAKHY CCCCCCCCHHHHHHH	28.46	23401153
941	Phosphorylation	DLAKHYKSASPQPAF HHHHHHHCCCCCCCC	27.15	27732954
943	Phosphorylation	AKHYKSASPQPAFHL HHHHHCCCCCCCCCC	31.03	27422710
954	Phosphorylation	AFHLKPDTPVSVKKH CCCCCCCCCCEECCC	33.83	27422710
957	Phosphorylation	LKPDTPVSVKKHHVI CCCCCCCEECCCCEE	29.44	27732954
1109	Phosphorylation	RTEADGNSDPNSDGP CCCCCCCCCCCCCCC	61.03	24076635
1156	Phosphorylation	GPYQHPKSPLSTFAP CCCCCCCCCHHCCCC	35.21	25159151
1221	Phosphorylation	IPLANLKSYKQAGGA CCHHHHHHHHHCCCC	40.50	21253578
1222	Phosphorylation	PLANLKSYKQAGGAT CHHHHHHHHHCCCCC	12.92	21253578
1229	Phosphorylation	YKQAGGATESPKEHQ HHHCCCCCCCCCCCC	40.03	30001349
1231	Phosphorylation	QAGGATESPKEHQL- HCCCCCCCCCCCCC-	36.60	30001349

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCDH9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCDH9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCDH9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MEOX2_HUMAN	MEOX2	physical	24722188
IKIP_HUMAN	IKBIP	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.