CNNM3_HUMAN - dbPTM
CNNM3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CNNM3_HUMAN
UniProt AC Q8NE01
Protein Name Metal transporter CNNM3
Gene Name CNNM3
Organism Homo sapiens (Human).
Sequence Length 707
Subcellular Localization Cell membrane
Multi-pass membrane protein.
Protein Description Probable metal transporter..
Protein Sequence MAAAVAAAGRLGWLFAALCLGNAAGEAAPGPRVLGFCLEEDGAAGAGWVRGGAARDTPDATFLLRLFGPGFANSSWSWVAPEGAGCREEAASPAGEWRALLRLRLRAEAVRPHSALLAVRVEPGGGAAEEAAPPWALGLGAAGLLALAALARGLQLSALALAPAEVQVLRESGSEAERAAARRLEPARRWAGCALGALLLLASLAQAALAVLLYRAAGQRAVPAVLGSAGLVFLVGEVVPAAVSGRWTLALAPRALGLSRLAVLLTLPVALPVGQLLELAARPGRLRERVLELARGGGDPYSDLSKGVLRCRTVEDVLTPLEDCFMLDASTVLDFGVLASIMQSGHTRIPVYEEERSNIVDMLYLKDLAFVDPEDCTPLSTITRFYNHPLHFVFNDTKLDAVLEEFKRGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIRSEILDESEDYRDTVVKRKPASLMAPLKRKEEFSLFKVSDDEYKVTISPQLLLATQRFLSREVDVFSPLRISEKVLLHLLKHPSVNQEVRFDESNRLATHHYLYQRSQPVDYFILILQGRVEVEIGKEGLKFENGAFTYYGVSALTVPSSVHQSPVSSLQPIRHDLQPDPGDGTHSSAYCPDYTVRALSDLQLIKVTRLQYLNALLATRAQNLPQSPENTDLQVIPGSQTRLLGEKTTTAAGSSHSRPGVPVEGSPGRNPGV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
73N-linked_GlycosylationLFGPGFANSSWSWVA
HHCCCCCCCCCEEEC		34.02UniProtKB CARBOHYD
92PhosphorylationGCREEAASPAGEWRA
CCCHHHCCCCHHHHH		23.48-
295MethylationERVLELARGGGDPYS
HHHHHHHCCCCCCHH		57.84-
301PhosphorylationARGGGDPYSDLSKGV
HCCCCCCHHHHCCCC		21.4028796482
302PhosphorylationRGGGDPYSDLSKGVL
CCCCCCHHHHCCCCC		37.1528796482
305PhosphorylationGDPYSDLSKGVLRCR
CCCHHHHCCCCCCCC		32.1428796482
306 (in isoform 1)Ubiquitination-61.4021890473
306 (in isoform 2)Ubiquitination-61.4021890473
306 (in isoform 3)Ubiquitination-61.4021890473
306UbiquitinationDPYSDLSKGVLRCRT
CCHHHHCCCCCCCCC		61.4023000965
352PhosphorylationGHTRIPVYEEERSNI
CCCCCCCCHHHHHCC		16.5627642862
364PhosphorylationSNIVDMLYLKDLAFV
HCCCCEEEEECCCCC		12.69-
407UbiquitinationDAVLEEFKRGKSHLA
HHHHHHHHCCCCEEE		64.6229967540
410UbiquitinationLEEFKRGKSHLAIVQ
HHHHHCCCCEEEEEE		38.4429901268
411PhosphorylationEEFKRGKSHLAIVQK
HHHHCCCCEEEEEEE		26.9324114839
414UbiquitinationKRGKSHLAIVQKVNN
HCCCCEEEEEEECCC		8.4223000965
416UbiquitinationGKSHLAIVQKVNNEG
CCCEEEEEEECCCCC		3.6123000965
425UbiquitinationKVNNEGEGDPFYEVL
ECCCCCCCCCHHHHH		59.7632015554
427UbiquitinationNNEGEGDPFYEVLGL
CCCCCCCCHHHHHEE		44.5732015554
434UbiquitinationPFYEVLGLVTLEDVI
CHHHHHEEEEHHHHH		2.0229967540
441UbiquitinationLVTLEDVIEEIIRSE
EEEHHHHHHHHHHHH		6.4232015554
441 (in isoform 2)Ubiquitination-6.42-
453PhosphorylationRSEILDESEDYRDTV
HHHCCCCCCCHHHHC		35.1228796482
456PhosphorylationILDESEDYRDTVVKR
CCCCCCCHHHHCHHC		13.3128796482
459PhosphorylationESEDYRDTVVKRKPA
CCCCHHHHCHHCCCC		20.4228796482
462 (in isoform 1)Ubiquitination-50.8221890473
462UbiquitinationDYRDTVVKRKPASLM
CHHHHCHHCCCCCCC		50.8223000965
464UbiquitinationRDTVVKRKPASLMAP
HHHCHHCCCCCCCCC		38.9423000965
467PhosphorylationVVKRKPASLMAPLKR
CHHCCCCCCCCCCCC		27.4923898821
471UbiquitinationKPASLMAPLKRKEEF
CCCCCCCCCCCHHHC		25.1721890473
471 (in isoform 2)Ubiquitination-25.1721890473
471 (in isoform 3)Ubiquitination-25.1721890473
473UbiquitinationASLMAPLKRKEEFSL
CCCCCCCCCHHHCCE		61.4332015554
475UbiquitinationLMAPLKRKEEFSLFK
CCCCCCCHHHCCEEE		61.0732015554
478UbiquitinationPLKRKEEFSLFKVSD
CCCCHHHCCEEEECC		8.9021890473
478 (in isoform 2)Ubiquitination-8.9021890473
478 (in isoform 3)Ubiquitination-8.9021890473
479PhosphorylationLKRKEEFSLFKVSDD
CCCHHHCCEEEECCC		35.8524719451
482UbiquitinationKEEFSLFKVSDDEYK
HHHCCEEEECCCCCE		46.2329967540
484PhosphorylationEFSLFKVSDDEYKVT
HCCEEEECCCCCEEE		39.6829978859
488PhosphorylationFKVSDDEYKVTISPQ
EEECCCCCEEEECHH		20.1129978859
489UbiquitinationKVSDDEYKVTISPQL
EECCCCCEEEECHHH		30.7432015554
491PhosphorylationSDDEYKVTISPQLLL
CCCCCEEEECHHHHH		16.1629978859
512PhosphorylationSREVDVFSPLRISEK
CCCCCCCCCCCCCHH		23.91-
519UbiquitinationSPLRISEKVLLHLLK
CCCCCCHHHHHHHHH		31.2423000965
519 (in isoform 1)Ubiquitination-31.2421890473
524UbiquitinationSEKVLLHLLKHPSVN
CHHHHHHHHHCCCCC		7.4129901268
526UbiquitinationKVLLHLLKHPSVNQE
HHHHHHHHCCCCCCE		60.8821890473
526 (in isoform 1)Ubiquitination-60.8821890473
529PhosphorylationLHLLKHPSVNQEVRF
HHHHHCCCCCCEECC		33.1620873877
552PhosphorylationHHYLYQRSQPVDYFI
CHHHHHCCCCCCEEE		24.2624719451
557PhosphorylationQRSQPVDYFILILQG
HCCCCCCEEEEEEEC		7.8630108239
572UbiquitinationRVEVEIGKEGLKFEN
CEEEEECCCCEEEEC		55.0329901268
588PhosphorylationAFTYYGVSALTVPSS
CEEEEEEEEEECCCC		17.1328122231
591PhosphorylationYYGVSALTVPSSVHQ
EEEEEEEECCCCCCC		30.0425850435
592 (in isoform 2)Ubiquitination-4.5021890473
592 (in isoform 3)Ubiquitination-4.5021890473
592UbiquitinationYGVSALTVPSSVHQS
EEEEEEECCCCCCCC		4.5021890473
594PhosphorylationVSALTVPSSVHQSPV
EEEEECCCCCCCCCC		40.4328122231
595PhosphorylationSALTVPSSVHQSPVS
EEEECCCCCCCCCCC		19.9725850435
599PhosphorylationVPSSVHQSPVSSLQP
CCCCCCCCCCCCCCC		16.6426657352
602PhosphorylationSVHQSPVSSLQPIRH
CCCCCCCCCCCCCCC		28.8125850435
603PhosphorylationVHQSPVSSLQPIRHD
CCCCCCCCCCCCCCC		31.1225850435
624PhosphorylationDGTHSSAYCPDYTVR
CCCCCCCCCCCCCEE		13.38-
633UbiquitinationPDYTVRALSDLQLIK
CCCCEEECCHHCCEE		2.6129967540
640 (in isoform 1)Ubiquitination-46.2621890473
640UbiquitinationLSDLQLIKVTRLQYL
CCHHCCEEHHHHHHH		46.2623000965
652PhosphorylationQYLNALLATRAQNLP
HHHHHHHHHHHHCCC		8.9032142685
661PhosphorylationRAQNLPQSPENTDLQ
HHHCCCCCCCCCCCE		32.0429255136
665PhosphorylationLPQSPENTDLQVIPG
CCCCCCCCCCEEECC		36.1029255136
673PhosphorylationDLQVIPGSQTRLLGE
CCEEECCCCEEECCE		24.0329255136
675PhosphorylationQVIPGSQTRLLGEKT
EEECCCCEEECCEEE		25.6129255136
681UbiquitinationQTRLLGEKTTTAAGS
CEEECCEEEECCCCC		49.7429967540
682PhosphorylationTRLLGEKTTTAAGSS
EEECCEEEECCCCCC		25.6923927012
683PhosphorylationRLLGEKTTTAAGSSH
EECCEEEECCCCCCC		26.0424732914
684PhosphorylationLLGEKTTTAAGSSHS
ECCEEEECCCCCCCC		21.5323927012
688PhosphorylationKTTTAAGSSHSRPGV
EEECCCCCCCCCCCC		21.8323927012
689PhosphorylationTTTAAGSSHSRPGVP
EECCCCCCCCCCCCC		25.2723927012
691PhosphorylationTAAGSSHSRPGVPVE
CCCCCCCCCCCCCCC		41.9623401153
700PhosphorylationPGVPVEGSPGRNPGV
CCCCCCCCCCCCCCC		15.6319664994
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CNNM3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CNNM3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CNNM3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KR412_HUMANKRTAP4-12physical
16189514
MDFI_HUMANMDFIphysical
19060904
TF65_HUMANRELAphysical
21988832
UB2G2_HUMANUBE2G2physical
21988832
USBP1_HUMANUSHBP1physical
25416956
KRA32_HUMANKRTAP3-2physical
25416956
LZTS2_HUMANLZTS2physical
25416956
KRA23_HUMANKRTAP2-4physical
25416956
KRA24_HUMANKRTAP2-4physical
25416956
SPERT_HUMANSPERTphysical
25416956
KR109_HUMANKRTAP10-9physical
25416956
KR108_HUMANKRTAP10-8physical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CNNM3_HUMAN

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-691 AND SER-700, ANDMASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory