CNNM2_HUMAN - dbPTM
CNNM2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CNNM2_HUMAN
UniProt AC Q9H8M5
Protein Name Metal transporter CNNM2
Gene Name CNNM2
Organism Homo sapiens (Human).
Sequence Length 875
Subcellular Localization Cell membrane
Multi-pass membrane protein.
Protein Description Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity)..
Protein Sequence MIGCGACEPKVKMAGGQAAAALPTWKMAARRSLSARGRGILQAAAGRLLPLLLLSCCCGAGGCAAVGENEETVIIGLRLEDTNDVSFMEGGALRVSERTRVKLRVYGQNINNETWSRIAFTEHERRRHSPGERGLGGPAPPEPDSGPQRCGIRTSDIIILPHIILNRRTSGIIEIEIKPLRKMEKSKSYYLCTSLSTPALGAGGSGSTGGAVGGKGGSGVAGLPPPPWAETTWIYHDGEDTKMIVGEEKKFLLPFWLQVIFISLLLCLSGMFSGLNLGLMALDPMELRIVQNCGTEKEKNYAKRIEPVRRQGNYLLCSLLLGNVLVNTTLTILLDDIAGSGLVAVVVSTIGIVIFGEIVPQAICSRHGLAVGANTIFLTKFFMMMTFPASYPVSKLLDCVLGQEIGTVYNREKLLEMLRVTDPYNDLVKEELNIIQGALELRTKTVEDVMTPLRDCFMITGEAILDFNTMSEIMESGYTRIPVFEGERSNIVDLLFVKDLAFVDPDDCTPLKTITKFYNHPLHFVFNDTKLDAMLEEFKKGKSHLAIVQRVNNEGEGDPFYEVLGIVTLEDVIEEIIKSEILDETDLYTDNRTKKKVAHRERKQDFSAFKQTDSEMKVKISPQLLLAMHRFLATEVEAFSPSQMSEKILLRLLKHPNVIQELKYDEKNKKAPEYYLYQRNKPVDYFVLILQGKVEVEAGKEGMKFEASAFSYYGVMALTASPVPLSLSRTFVVSRTELLAAGSPGENKSPPRPCGLNHSDSLSRSDRIDAVTPTLGSSNNQLNSSLLQVYIPDYSVRALSDLQFVKISRQQYQNALMASRMDKTPQSSDSENTKIELTLTELHDGLPDETANLLNEQNCVTHSKANHSLHNEGAI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
96PhosphorylationEGGALRVSERTRVKL
CCCEEEECCCCEEEE		18.2228634120
99PhosphorylationALRVSERTRVKLRVY
EEEECCCCEEEEEEE		35.4428634120
106PhosphorylationTRVKLRVYGQNINNE
CEEEEEEECEECCCC		13.4227050516
112N-linked_GlycosylationVYGQNINNETWSRIA
EECEECCCCCEEEEE		44.25UniProtKB CARBOHYD
129PhosphorylationEHERRRHSPGERGLG
HHHHHHCCCCCCCCC		32.56-
194O-linked_GlycosylationKSYYLCTSLSTPALG
CCEEEEHHCCCCCCC		21.23OGP
197O-linked_GlycosylationYLCTSLSTPALGAGG
EEEHHCCCCCCCCCC		20.20OGP
413 (in isoform 2)Ubiquitination-55.9521890473
413 (in isoform 1)Ubiquitination-55.9521890473
413 (in isoform 3)Ubiquitination-55.9521890473
413UbiquitinationGTVYNREKLLEMLRV
HCEECHHHHHHHHHC		55.9523000965
424PhosphorylationMLRVTDPYNDLVKEE
HHHCCCCCHHHHHHH		24.9027642862
429UbiquitinationDPYNDLVKEELNIIQ
CCCHHHHHHHHHHHH		53.4129967540
512UbiquitinationPDDCTPLKTITKFYN
CCCCCCCHHHHHHHC		38.8029967540
539UbiquitinationDAMLEEFKKGKSHLA
HHHHHHHHCCCCEEE		64.99-
540MethylationAMLEEFKKGKSHLAI
HHHHHHHCCCCEEEE		76.52-
540 (in isoform 3)Methylation-76.52-
542UbiquitinationLEEFKKGKSHLAIVQ
HHHHHCCCCEEEEEE		43.5129967540
545 (in isoform 3)Methylation-4.49-
585PhosphorylationKSEILDETDLYTDNR
HCCCCCCCCCCCCCC		30.8522468782
588PhosphorylationILDETDLYTDNRTKK
CCCCCCCCCCCCHHH		18.1728796482
589PhosphorylationLDETDLYTDNRTKKK
CCCCCCCCCCCHHHH		33.8128796482
593PhosphorylationDLYTDNRTKKKVAHR
CCCCCCCHHHHHHHH		54.1722468782
603UbiquitinationKVAHRERKQDFSAFK
HHHHHHHHHCHHHHH		49.8429967540
607PhosphorylationRERKQDFSAFKQTDS
HHHHHCHHHHHCCCC		40.8824532841
610UbiquitinationKQDFSAFKQTDSEMK
HHCHHHHHCCCCHHH		52.5929967540
612PhosphorylationDFSAFKQTDSEMKVK
CHHHHHCCCCHHHCC		41.9228258704
614PhosphorylationSAFKQTDSEMKVKIS
HHHHCCCCHHHCCCC		42.87-
708PhosphorylationEGMKFEASAFSYYGV
CCCEEEEEECEEEEE		23.7319835603
711PhosphorylationKFEASAFSYYGVMAL
EEEEEECEEEEEEEE		19.7019835603
712PhosphorylationFEASAFSYYGVMALT
EEEEECEEEEEEEEE		9.5919835603
713PhosphorylationEASAFSYYGVMALTA
EEEECEEEEEEEEEC		11.3119835603
726PhosphorylationTASPVPLSLSRTFVV
ECCCCCCCCCCEEEE		20.4424719451
728PhosphorylationSPVPLSLSRTFVVSR
CCCCCCCCCEEEEEH		26.3717081983
743PhosphorylationTELLAAGSPGENKSP
HHHHHCCCCCCCCCC		25.6326425664
749PhosphorylationGSPGENKSPPRPCGL
CCCCCCCCCCCCCCC		52.2823663014
759PhosphorylationRPCGLNHSDSLSRSD
CCCCCCCCCCCCHHH		28.0229116813
761PhosphorylationCGLNHSDSLSRSDRI
CCCCCCCCCCHHHCC		31.1229116813
763PhosphorylationLNHSDSLSRSDRIDA
CCCCCCCCHHHCCCE		33.4229116813
868PhosphorylationTHSKANHSLHNEGAI
CCCCCCCCCCCCCCC		31.0025159151
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CNNM2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CNNM2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CNNM2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CNNM2_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613882Hypomagnesemia 6 (HOMG6)
616418Hypomagnesemia, seizures, and mental retardation (HOMGSMR)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CNNM2_HUMAN

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Related Literatures of Post-Translational Modification

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