CD276_HUMAN - dbPTM
CD276_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CD276_HUMAN
UniProt AC Q5ZPR3
Protein Name CD276 antigen
Gene Name CD276
Organism Homo sapiens (Human).
Sequence Length 534
Subcellular Localization Membrane
Single-pass type I membrane protein .
Protein Description May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling..
Protein Sequence MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYQGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVRNPVLQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFTEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYRGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPMTFPPEALWVTVGLSVCLIALLVALAFVCWRKIKQSCEEENAGAEDQDGEGEGSKTALQPLKHSDSKEDDGQEIA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
104N-linked_GlycosylationPDLLAQGNASLRLQR
HHHHHCCCCEEEEEE		17.8019159218
106PhosphorylationLLAQGNASLRLQRVR
HHHCCCCEEEEEEEE		20.3027251275
144 (in isoform 1)Ubiquitination-34.9621906983
144 (in isoform 2)Ubiquitination-34.9621906983
144 (in isoform 3)Ubiquitination-34.9621906983
144 (in isoform 4)Ubiquitination-34.9621906983
144UbiquitinationQVAAPYSKPSMTLEP
EEECCCCCCCCEECC		34.96-
189N-linked_GlycosylationQGVPLTGNVTTSQMA
CCCCCCCCEEHHHHC		23.7919159218
215N-linked_GlycosylationLRVVLGANGTYSCLV
HHHHHCCCCEEEEEE		41.35UniProtKB CARBOHYD
236O-linked_GlycosylationQDAHSSVTITPQRSP
CCCCCCCEECCCCCC		22.53OGP
244PhosphorylationITPQRSPTGAVEVQV
ECCCCCCCCCEEEEC		38.7325022875
262PhosphorylationPVVALVGTDATLRCS
CEEEEEECCCEEEEE		18.2518452278
265PhosphorylationALVGTDATLRCSFSP
EEEECCCEEEEECCC		19.9718452278
303 (in isoform 2)Ubiquitination-46.51-
308 (in isoform 2)Ubiquitination-9.9521906983
322N-linked_GlycosylationPDLLAQGNASLRLQR
HHHHHCCCCEEEEEE		17.8019159218
324PhosphorylationLLAQGNASLRLQRVR
HHHCCCCEEEEEEEE		20.3027251275
362UbiquitinationQVAAPYSKPSMTLEP
EEECCCCCCCCEECC		34.96-
383S-palmitoylationGDTVTITCSSYRGYP
CCEEEEEECCCCCCC		1.9429575903
407N-linked_GlycosylationQGVPLTGNVTTSQMA
CCCCCCCCEEHHHHC		23.7919159218
433N-linked_GlycosylationLRVVLGANGTYSCLV
HHHHHCCCCEEEEEE		41.35UniProtKB CARBOHYD
495PhosphorylationCWRKIKQSCEEENAG
HHHHHHHHHHHHCCC		20.6325002506
496S-palmitoylationWRKIKQSCEEENAGA
HHHHHHHHHHHCCCC		7.6529575903
513PhosphorylationQDGEGEGSKTALQPL
CCCCCCCCCEECEEC		23.6426657352
515PhosphorylationGEGEGSKTALQPLKH
CCCCCCCEECEECCC		34.0130266825
521UbiquitinationKTALQPLKHSDSKED
CEECEECCCCCCCCC		47.98-
523PhosphorylationALQPLKHSDSKEDDG
ECEECCCCCCCCCCC		41.8330266825
525PhosphorylationQPLKHSDSKEDDGQE
EECCCCCCCCCCCCC		40.7429255136
526 (in isoform 1)Ubiquitination-70.8821906983
526UbiquitinationPLKHSDSKEDDGQEI
ECCCCCCCCCCCCCC		70.882190698
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CD276_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CD276_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CD276_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CD276_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CD276_HUMAN

loading...

Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-322 AND ASN-407, AND MASSSPECTROMETRY.
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-525, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory