AGRA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AGRA3_HUMAN
• UniProt AC: Q8IWK6
• Protein Name: Adhesion G protein-coupled receptor A3 {ECO:0000303|PubMed:25713288}
• Gene Name: ADGRA3 {ECO:0000312|HGNC:HGNC:13839}
• Organism: Homo sapiens (Human).
• Sequence Length: 1321
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Orphan receptor that may have a role in planar cell polarity pathway..
• Protein Sequence: MEPPGRRRGRAQPPLLLPLSLLALLALLGGGGGGGAAALPAGCKHDGRPRGAGRAAGAAEGKVVCSSLELAQVLPPDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYLLCDCNILWMHRWVKEKNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLPFQCMASYIDQDMQVLWYQDGRIVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKRGNNTRTVDIVVLESSAQYCPPERVVNNKGDFRWPRTLAGITAYLQCTRNTHGSGIYPGNPQDERKAWRRCDRGGFWADDDYSRCQYANDVTRVLYMFNQMPLNLTNAVATARQLLAYTVEAANFSDKMDVIFVAEMIEKFGRFTKEEKSKELGDVMVDIASNIMLADERVLWLAQREAKACSRIVQCLQRIATYRLAGGAHVYSTYSPNIALEAYVIKSTGFTGMTCTVFQKVAASDRTGLSDYGRRDPEGNLDKQLSFKCNVSNTFSSLALKNTIVEASIQLPPSLFSPKQKRELRPTDDSLYKLQLIAFRNGKLFPATGNSTNLADDGKRRTVVTPVILTKIDGVNVDTHHIPVNVTLRRIAHGADAVAARWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSLSNYAVLMDLTGSELYTQAASLLHPVVYTTAIILLLCLLAVIVSYIYHHSLIRISLKSWHMLVNLCFHIFLTCVVFVGGITQTRNASICQAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKRCQDPDEPPPPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSRPNAPYCWMAWEPSLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEINHQDSMSLSLISTSALENEHTFHSQLLGASLTLLLYVALWMFGALAVSLYYPLDLVFSFVFGATSLSFSAFFVVHHCVNREDVRLAWIMTCCPGRSSYSVQVNVQPPNSNGTNGEAPKCPNSSAESSCTNKSASSFKNSSQGCKLTNLQAAAAQCHANSLPLNSTPQLDNSLTEHSMDNDIKMHVAPLEVQFRTNVHSSRHHKNRSKGHRASRLTVLREYAYDVPTSVEGSVQNGLPKSRLGNNEGHSRSRRAYLAYRERQYNPPQQDSSDACSTLPKSSRNFEKPVSTTSKKDALRKPAVVELENQQKSYGLNLAIQNGPIKSNGQEGPLLGTDSTGNVRTGLWKHETTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	N-linked_Glycosylation	LPPDTLPNRTVTLIL CCCCCCCCCEEEEEE		UniProtKB CARBOHYD
98	N-linked_Glycosylation	NKISELKNGSFSGLS CCHHHCCCCCCCCHH		UniProtKB CARBOHYD
129	Phosphorylation	PGAFWGLSSLKRLDL CCHHCCHHHCCCCCC		24719451
159	N-linked_Glycosylation	LTNLVRLNLSGNLFS CHHHEEEECCCCCCH		UniProtKB CARBOHYD
178	Phosphorylation	GTFDYLASLRSLEFQ CHHHHHHHHHCCCCC		24719451
206	N-linked_Glycosylation	HRWVKEKNITVRDTR EHHHHHCCCEEECCE		UniProtKB CARBOHYD
208	Phosphorylation	WVKEKNITVRDTRCV HHHHCCCEEECCEEE		22817900
301	N-linked_Glycosylation	VEKNMIHNCSLIASA EECCCCCCHHHHHHE		UniProtKB CARBOHYD
332	N-linked_Glycosylation	HVQTKRGNNTRTVDI EEEEECCCCCEEEEE		UniProtKB CARBOHYD
334	Phosphorylation	QTKRGNNTRTVDIVV EEECCCCCEEEEEEE		-
336	Phosphorylation	KRGNNTRTVDIVVLE ECCCCCEEEEEEEEE		-
344	Phosphorylation	VDIVVLESSAQYCPP EEEEEEECCCCCCCH		-
366	Phosphorylation	GDFRWPRTLAGITAY CCCCCCCHHHHHHEE		-
373	Phosphorylation	TLAGITAYLQCTRNT HHHHHHEEEECCCCC		-
433	N-linked_Glycosylation	MFNQMPLNLTNAVAT HHHCCCCCHHHHHHH		UniProtKB CARBOHYD
453	N-linked_Glycosylation	AYTVEAANFSDKMDV HHHHHHCCCCCCCHH		UniProtKB CARBOHYD
588	Phosphorylation	GNLDKQLSFKCNVSN CCCCHHEEEEEECCC		24719451
592	N-linked_Glycosylation	KQLSFKCNVSNTFSS HHEEEEEECCCCCCH		UniProtKB CARBOHYD
619	Phosphorylation	QLPPSLFSPKQKREL CCCHHHCCHHHCCCC		24719451
632	Phosphorylation	ELRPTDDSLYKLQLI CCCCCCCCHHHHHEE		24667141
635	Ubiquitination	PTDDSLYKLQLIAFR CCCCCHHHHHEEEEE		-
652	N-linked_Glycosylation	KLFPATGNSTNLADD EEEECCCCCCCCCCC		UniProtKB CARBOHYD
687	N-linked_Glycosylation	DTHHIPVNVTLRRIA CCCCCCCCHHHHHHH		UniProtKB CARBOHYD
728	N-linked_Glycosylation	HILYSDENITTIQCY EEEECCCCEEEEEEE		UniProtKB CARBOHYD
821	N-linked_Glycosylation	GGITQTRNASICQAV CCCCCCCCHHHHHHH		UniProtKB CARBOHYD
878	Phosphorylation	PRPMLRFYLIGGGIP CCCEEEEEEECCCCC		24667141
950	Phosphorylation	KRHPERKYELKEPTE HHCCCCCCCCCCCCH		-
1097	Phosphorylation	PNSSAESSCTNKSAS CCCCCCCCCCCCCHH		-
1099	Phosphorylation	SSAESSCTNKSASSF CCCCCCCCCCCHHHC		-
1101	Ubiquitination	AESSCTNKSASSFKN CCCCCCCCCHHHCCC		32142685
1102	Phosphorylation	ESSCTNKSASSFKNS CCCCCCCCHHHCCCC		-
1182	Phosphorylation	RSKGHRASRLTVLRE CCCCCHHHHHHHHHH		22210691
1185	Phosphorylation	GHRASRLTVLREYAY CCHHHHHHHHHHHHC		27642862
1190	Phosphorylation	RLTVLREYAYDVPTS HHHHHHHHHCCCCCC		27642862
1224	Phosphorylation	HSRSRRAYLAYRERQ CCHHHHHHHHHHHHH		25884760
1232	Phosphorylation	LAYRERQYNPPQQDS HHHHHHHCCCCCCCC		29759185
1239	Phosphorylation	YNPPQQDSSDACSTL CCCCCCCCCCHHHCC		28348404
1240	Phosphorylation	NPPQQDSSDACSTLP CCCCCCCCCHHHCCC		28348404
1244	Phosphorylation	QDSSDACSTLPKSSR CCCCCHHHCCCCCCC		29759185
1245	Phosphorylation	DSSDACSTLPKSSRN CCCCHHHCCCCCCCC		28555341
1248	Ubiquitination	DACSTLPKSSRNFEK CHHHCCCCCCCCCCC		-
1250	Phosphorylation	CSTLPKSSRNFEKPV HHCCCCCCCCCCCCC		27251275
1258	Phosphorylation	RNFEKPVSTTSKKDA CCCCCCCCCCCHHHH		27251275
1259	Phosphorylation	NFEKPVSTTSKKDAL CCCCCCCCCCHHHHH		27251275
1260	Phosphorylation	FEKPVSTTSKKDALR CCCCCCCCCHHHHHC		27251275
1261	Phosphorylation	EKPVSTTSKKDALRK CCCCCCCCHHHHHCC		27251275
1294	Phosphorylation	IQNGPIKSNGQEGPL EECCCCCCCCCCCCC		22210691
1316	Ubiquitination	NVRTGLWKHETTV-- CCCCCCCCCCCCC--		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AGRA3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AGRA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AGRA3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of AGRA3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.