TMM59_HUMAN - dbPTM
TMM59_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TMM59_HUMAN
UniProt AC Q9BXS4
Protein Name Transmembrane protein 59
Gene Name TMEM59
Organism Homo sapiens (Human).
Sequence Length 323
Subcellular Localization Late endosome membrane
Single-pass type I membrane protein . Lysosome membrane
Single-pass type I membrane protein . Cell membrane
Single-pass type I membrane protein . Golgi apparatus membrane
Single-pass type I membrane protein . Mainly loc
Protein Description Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. [PubMed: 27273576]
Protein Sequence MAAPKGSLWVRTQLGLPPLLLLTMALAGGSGTASAEAFDSVLGDTASCHRACQLTYPLHTYPKEEELYACQRGCRLFSICQFVDDGIDLNRTKLECESACTEAYSQSDEQYACHLGCQNQLPFAELRQEQLMSLMPKMHLLFPLTLVRSFWSDMMDSAQSFITSSWTFYLQADDGKIVIFQSKPEIQYAPHLEQEPTNLRESSLSKMSYLQMRNSQAHRNFLEDGESDGFLRCLSLNSGWILTTTLVLSVMVLLWICCATVATAVEQYVPSEKLSIYGDLEFMNEQKLNRYPASSLVVVRSKTEDHEEAGPLPTKVNLAHSEI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
61PhosphorylationLTYPLHTYPKEEELY
CCCCCCCCCCHHHHH		11.1029759185
63UbiquitinationYPLHTYPKEEELYAC
CCCCCCCCHHHHHHC		68.30-
90N-linked_GlycosylationVDDGIDLNRTKLECE
CCCCCCCCCHHHHHH		45.9120427278
133PhosphorylationLRQEQLMSLMPKMHL
HHHHHHHHHHHHHHH		30.0620068231
182O-linked_GlycosylationGKIVIFQSKPEIQYA
CCEEEEECCCCCCCC		39.15OGP
183UbiquitinationKIVIFQSKPEIQYAP
CEEEEECCCCCCCCC		35.5721906983
202PhosphorylationEPTNLRESSLSKMSY
CCCCCCCHHHHHHHH		30.0923403867
203PhosphorylationPTNLRESSLSKMSYL
CCCCCCHHHHHHHHH		31.7323403867
205PhosphorylationNLRESSLSKMSYLQM
CCCCHHHHHHHHHHH		28.4123403867
206UbiquitinationLRESSLSKMSYLQMR
CCCHHHHHHHHHHHH		36.8421890473
208PhosphorylationESSLSKMSYLQMRNS
CHHHHHHHHHHHHCC		26.8223403867
209PhosphorylationSSLSKMSYLQMRNSQ
HHHHHHHHHHHHCCH		9.4623403867
227PhosphorylationNFLEDGESDGFLRCL
HHHHCCCCCCCEEEE		48.87-
228PhosphorylationFLEDGESDGFLRCLS
HHHCCCCCCCEEEEE		47.78-
275PhosphorylationYVPSEKLSIYGDLEF
HCCHHHCEEEECHHH		25.4928152594
277PhosphorylationPSEKLSIYGDLEFMN
CHHHCEEEECHHHHC		10.9528152594
287UbiquitinationLEFMNEQKLNRYPAS
HHHHCHHHHCCCCCC		41.3621890473
288UbiquitinationEFMNEQKLNRYPASS
HHHCHHHHCCCCCCC		4.39-
291PhosphorylationNEQKLNRYPASSLVV
CHHHHCCCCCCCEEE		11.3228152594
294PhosphorylationKLNRYPASSLVVVRS
HHCCCCCCCEEEEEE		21.5028152594
295PhosphorylationLNRYPASSLVVVRSK
HCCCCCCCEEEEEEC		27.5628152594
296PhosphorylationNRYPASSLVVVRSKT
CCCCCCCEEEEEECC		2.91-
301PhosphorylationSSLVVVRSKTEDHEE
CCEEEEEECCCCHHH		32.1123312004
302UbiquitinationSLVVVRSKTEDHEEA
CEEEEEECCCCHHHC		45.4221906983
303PhosphorylationLVVVRSKTEDHEEAG
EEEEEECCCCHHHCC		48.1423312004
303UbiquitinationLVVVRSKTEDHEEAG
EEEEEECCCCHHHCC		48.14-
304PhosphorylationVVVRSKTEDHEEAGP
EEEEECCCCHHHCCC		62.19-
314PhosphorylationEEAGPLPTKVNLAHS
HHCCCCCCCEEECCC		56.1423312004
315UbiquitinationEAGPLPTKVNLAHSE
HCCCCCCCEEECCCC		27.4721890473
315UbiquitinationEAGPLPTKVNLAHSE
HCCCCCCCEEECCCC		27.4722053931
316UbiquitinationAGPLPTKVNLAHSEI
CCCCCCCEEECCCCC		8.58-
321PhosphorylationTKVNLAHSEI-----
CCEEECCCCC-----		31.2320068231
322PhosphorylationKVNLAHSEI------
CEEECCCCC------		42.7420068231
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TMM59_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TMM59_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TMM59_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A16L1_HUMANATG16L1physical
23376921
TYW1_HUMANTYW1physical
26186194
PDE3B_HUMANPDE3Bphysical
26186194
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TMM59_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory