AGRA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AGRA2_HUMAN
• UniProt AC: Q96PE1
• Protein Name: Adhesion G protein-coupled receptor A2 {ECO:0000312|HGNC:HGNC:17849}
• Gene Name: ADGRA2 {ECO:0000312|HGNC:HGNC:17849}
• Organism: Homo sapiens (Human).
• Sequence Length: 1338
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cell projection, filopodium . Enriched at lateral cell borders and also at sites of cell-ECM (extracellular matrix) contact.
• Protein Description: Endothelial receptor which functions as a WNT7-specific coactivator of canonical Wnt signaling (By similarity). Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity). Has a major role in establishing the blood-brain barrier (By similarity). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate. [PubMed: 16982628]
• Protein Sequence: MGAGGRRMRGAPARLLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGPARRRVVCSGGDLPEPPEPGLLPNGTVTLLLSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDCTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAERVANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSRIVGALERIGGAALSPHAQHISVNARNVALEAYLIKPHSYVGLTCTAFQRREGGVPGTRPGSPGQNPPPEPEPPADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSLPAALAPPVPPDCTLQLLVFRNGRLFHSHSNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAEPVAAWWSQEGPGEAGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSAFPREVGGAGAGLHPVVYPCTALLLLCLFATIITYILNHSSIRVSRKGWHMLLNLCFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLSTLLWMGVKARVLHKELTWRAPPPQEGDPALPTPSPMLRFYLIAGGIPLIICGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQNPKAGNSRASLEAGEELRGSTRLRGSGPLLSDSGSLLATGSARVGTPGPPEDGDSLYSPGVQLGALVTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACCPPASPAAPHAPPRALPAAAEDGSPVFGEGPPSLKSSPSGSSGHPLALGPCKLTNLQLAQSQVCEAGAAAGGEGEPEPAGTRGNLAHRHPNNVHHGRRAHKSRAKGHRAGEACGKNRLKALRGGAAGALELLSSESGSLHNSPTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSDTSAAPLSEAGRAGQRRSASRDSLKGGGALEKESHRRSYPLNAASLNGAPKGGKYDDVTLMGAEVASGGCMKTGLWKSETTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
84	N-linked_Glycosylation	PEPGLLPNGTVTLLL CCCCCCCCCEEEEEE		UniProtKB CARBOHYD
97	Phosphorylation	LLSNNKITGLRNGSF EEECCCCCCCCCCCC		24719451
101	N-linked_Glycosylation	NKITGLRNGSFLGLS CCCCCCCCCCCHHHH		UniProtKB CARBOHYD
108	Phosphorylation	NGSFLGLSLLEKLDL CCCCHHHHHHHHHCC		24719451
162	N-linked_Glycosylation	LPRLLRLNISGNIFS CCCCCCEECCCCCHH		UniProtKB CARBOHYD
207	N-linked_Glycosylation	WLLPWAQNRSLQLSE HHHHHHHCCCCCCCC		UniProtKB CARBOHYD
253	Phosphorylation	HTHHLIPSLRQVVFQ HHHHHCHHHHHHHHC		17192257
275	N-linked_Glycosylation	CSASYLGNDTRIRWY EEEECCCCCCEEEEE		UniProtKB CARBOHYD
277	Phosphorylation	ASYLGNDTRIRWYHN EECCCCCCEEEEEEC		-
336	N-linked_Glycosylation	TVSMAQGNASKKVEI EEEEECCCCCCEEEE		UniProtKB CARBOHYD
348	Phosphorylation	VEIVVLETSASYCPA EEEEEEECCCCCCCH		30206219
349	Phosphorylation	EIVVLETSASYCPAE EEEEEECCCCCCCHH		30206219
351	Phosphorylation	VVLETSASYCPAERV EEEECCCCCCCHHHH		30206219
352	Phosphorylation	VLETSASYCPAERVA EEECCCCCCCHHHHH		30206219
370	Phosphorylation	GDFRWPRTLAGITAY CCCCCCCHHHHHHHH		19835603
377	Phosphorylation	TLAGITAYQSCLQYP HHHHHHHHHHHHCCC		19835603
379	Phosphorylation	AGITAYQSCLQYPFT HHHHHHHHHHCCCCC		19835603
386	O-linked_Glycosylation	SCLQYPFTSVPLGGG HHHCCCCCCCCCCCC		OGP
387	O-linked_Glycosylation	CLQYPFTSVPLGGGA HHCCCCCCCCCCCCC		OGP
436	N-linked_Glycosylation	TFVLMPINASNALTL EEEEEECCHHHHHHH		UniProtKB CARBOHYD
602	N-linked_Glycosylation	RCTTGRPNVSLSSFH EECCCCCCEEEEEEE		UniProtKB CARBOHYD
606	Phosphorylation	GRPNVSLSSFHIKNS CCCCEEEEEEEECCC		26853621
607	Phosphorylation	RPNVSLSSFHIKNSV CCCEEEEEEEECCCE		26853621
659	N-linked_Glycosylation	RLFHSHSNTSRPGAA EEEECCCCCCCCCCC		UniProtKB CARBOHYD
690	N-linked_Glycosylation	TSGCGVGNLTEPVAV CCCCCCCCCCCCHHH		UniProtKB CARBOHYD
698	Phosphorylation	LTEPVAVSLRHWAEG CCCCHHHHHHHHHCC		30576142
737	N-linked_Glycosylation	QLRSSQPNVSALHCQ EECCCCCCCEEEECC		UniProtKB CARBOHYD
774	Phosphorylation	AGLHPVVYPCTALLL CCCCCCHHHHHHHHH		-
777	Phosphorylation	HPVVYPCTALLLLCL CCCHHHHHHHHHHHH		-
880	O-linked_Glycosylation	EGDPALPTPSPMLRF CCCCCCCCCCHHHHH		29351928
882	O-linked_Glycosylation	DPALPTPSPMLRFYL CCCCCCCCHHHHHHH		29351928
963	Phosphorylation	QNPKAGNSRASLEAG CCCCCCCCCHHHHCH		26699800
966	Phosphorylation	KAGNSRASLEAGEEL CCCCCCHHHHCHHHH		26657352
976	Phosphorylation	AGEELRGSTRLRGSG CHHHHCCCCCCCCCC		24670416
977	Phosphorylation	GEELRGSTRLRGSGP HHHHCCCCCCCCCCC		26699800
982	Phosphorylation	GSTRLRGSGPLLSDS CCCCCCCCCCCCCCC		26657352
987	Phosphorylation	RGSGPLLSDSGSLLA CCCCCCCCCCCCEEE		29255136
989	Phosphorylation	SGPLLSDSGSLLATG CCCCCCCCCCEEEEC		29255136
991	Phosphorylation	PLLSDSGSLLATGSA CCCCCCCCEEEECCC		26657352
995	Phosphorylation	DSGSLLATGSARVGT CCCCEEEECCCCCCC		29255136
997	Phosphorylation	GSLLATGSARVGTPG CCEEEECCCCCCCCC		29255136
1107	Phosphorylation	PAAAEDGSPVFGEGP CCCCCCCCCCCCCCC		24925318
1116	Phosphorylation	VFGEGPPSLKSSPSG CCCCCCCCCCCCCCC		30266825
1119	Phosphorylation	EGPPSLKSSPSGSSG CCCCCCCCCCCCCCC		28450419
1120	Phosphorylation	GPPSLKSSPSGSSGH CCCCCCCCCCCCCCC		28450419
1122	Phosphorylation	PSLKSSPSGSSGHPL CCCCCCCCCCCCCCC		28450419
1124	Phosphorylation	LKSSPSGSSGHPLAL CCCCCCCCCCCCCCC		28450419
1125	Phosphorylation	KSSPSGSSGHPLALG CCCCCCCCCCCCCCC		28450419
1225	Phosphorylation	ESGSLHNSPTDSYLG CCCCCCCCCCCCCCC		24275569
1227	Phosphorylation	GSLHNSPTDSYLGSS CCCCCCCCCCCCCCC		-
1251	Phosphorylation	LEGEPMLTPSEGSDT ECCCCCCCCCCCCCC		30177828
1253	Phosphorylation	GEPMLTPSEGSDTSA CCCCCCCCCCCCCCC		30177828
1256	Phosphorylation	MLTPSEGSDTSAAPL CCCCCCCCCCCCCCH		26657352
1258	Phosphorylation	TPSEGSDTSAAPLSE CCCCCCCCCCCCHHH		30177828
1259	Phosphorylation	PSEGSDTSAAPLSEA CCCCCCCCCCCHHHC		30177828
1264	Phosphorylation	DTSAAPLSEAGRAGQ CCCCCCHHHCHHCCC		30177828
1274	Phosphorylation	GRAGQRRSASRDSLK HHCCCCCCCCCCCCC		23403867
1276	Phosphorylation	AGQRRSASRDSLKGG CCCCCCCCCCCCCCC		23403867
1279	Phosphorylation	RRSASRDSLKGGGAL CCCCCCCCCCCCCCC		26657352
1294	Phosphorylation	EKESHRRSYPLNAAS CCHHCCCCCCCCHHH		23403867
1295	Phosphorylation	KESHRRSYPLNAASL CHHCCCCCCCCHHHH		23403867
1329	Phosphorylation	ASGGCMKTGLWKSET ECCCCCCCCCCCCCC		23403867
1336	Phosphorylation	TGLWKSETTV----- CCCCCCCCCC-----		23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AGRA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AGRA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AGRA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DLG1_HUMAN	DLG1	physical	15021905

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.