JAG1_HUMAN - dbPTM
JAG1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID JAG1_HUMAN
UniProt AC P78504
Protein Name Protein jagged-1
Gene Name JAG1
Organism Homo sapiens (Human).
Sequence Length 1218
Subcellular Localization Membrane
Single-pass type I membrane protein.
Protein Description Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro)..
Protein Sequence MRSPRTRGRSGRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGARNPGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDRNRIVLPFSFAWPRSYTLLVEAWDSSNDTVQPDSIIEKASHSGMINPSRQWQTLKQNTGVAHFEYQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTSDSYYQDNCANITFTFNKEMMSPGLTTEHICSELRNLNILKNVSAEYSIYIACEPSPSANNEIHVAISAEDIRDDGNPIKEITDKIIDLVSKRDGNSSLIAAVAEVRVQRRPLKNRTDFLVPLLSSVLTVAWICCLVTAFYWCLRKRRKPGSHTHSASEDNTTNNVREQLNQIKNPIEKHGANTVPIKDYENKNSKMSKIRTHNSEVEEDDMDKHQQKARFAKQPAYTLVDREEKPPNGTPTKHPNWTNKQDNRDLESAQSLNRMEYIV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
80UbiquitinationTYFKVCLKEYQSRVT
HHHHHHHHHHHHCCC		49.61-
131PhosphorylationFSFAWPRSYTLLVEA
EECCCCCEEEEEEEE		20.5627732954
132PhosphorylationSFAWPRSYTLLVEAW
ECCCCCEEEEEEEEE		11.5927732954
133PhosphorylationFAWPRSYTLLVEAWD
CCCCCEEEEEEEEEC		18.1827732954
141PhosphorylationLLVEAWDSSNDTVQP
EEEEEECCCCCCCCC		21.9727732954
142PhosphorylationLVEAWDSSNDTVQPD
EEEEECCCCCCCCCC		35.9322468782
143N-linked_GlycosylationVEAWDSSNDTVQPDS
EEEECCCCCCCCCCH		53.58UniProtKB CARBOHYD
145PhosphorylationAWDSSNDTVQPDSII
EECCCCCCCCCCHHH		25.8727732954
150PhosphorylationNDTVQPDSIIEKASH
CCCCCCCHHHHHHCC		31.9527732954
156PhosphorylationDSIIEKASHSGMINP
CHHHHHHCCCCCCCH		29.2922468782
164PhosphorylationHSGMINPSRQWQTLK
CCCCCCHHHHHHHHH		32.3922468782
217N-linked_GlycosylationYACDQNGNKTCMEGW
EEECCCCCCCCCCCC		43.97UniProtKB CARBOHYD
219PhosphorylationCDQNGNKTCMEGWMG
ECCCCCCCCCCCCCC		22.5321060948
328PhosphorylationQCSCPEGYSGPNCEI
CCCCCCCCCCCCCEE		14.5922468782
342PhosphorylationIAEHACLSDPCHNRG
ECCHHHCCCCCCCCC		39.1122468782
350PhosphorylationDPCHNRGSCKETSLG
CCCCCCCCCCCCCCC		20.8322468782
382N-linked_GlycosylationIDDCSPNNCSHGGTC
CHHCCCCCCCCCCCH		31.86UniProtKB CARBOHYD
559N-linked_GlycosylationPEDYEGKNCSHLKDH
CCCCCCCCCHHHCHH		43.30UniProtKB CARBOHYD
569UbiquitinationHLKDHCRTTPCEVID
HHCHHHCCCCCEEEC		40.25-
607PhosphorylationGPHGKCKSQSGGKFT
CCCCCEECCCCCEEE		38.7630631047
609PhosphorylationHGKCKSQSGGKFTCD
CCCEECCCCCEEEEC		57.5130631047
728UbiquitinationYDEGDAFKCMCPGGW
CCCCCCEEEECCCCC		23.84-
745N-linked_GlycosylationTTCNIARNSSCLPNP
CCEEECCCCCCCCCC		29.29UniProtKB CARBOHYD
827PhosphorylationNINECQSSPCAFGAT
ECHHHCCCCCCCCCE		9.7122210691
842PhosphorylationCVDEINGYRCVCPPG
EEHEECCEEEECCCC		9.0622210691
960N-linked_GlycosylationYYQDNCANITFTFNK
HHCCCCEEEEEEECH		35.71UniProtKB CARBOHYD
964UbiquitinationNCANITFTFNKEMMS
CCEEEEEEECHHHCC		20.04-
969UbiquitinationTFTFNKEMMSPGLTT
EEEECHHHCCCCCCH		3.26-
971PhosphorylationTFNKEMMSPGLTTEH
EECHHHCCCCCCHHH		17.9526091039
978UbiquitinationSPGLTTEHICSELRN
CCCCCHHHHHHHHHC		25.02-
991N-linked_GlycosylationRNLNILKNVSAEYSI
HCCCHHCCCCEEEEE		29.54UniProtKB CARBOHYD
1045N-linked_GlycosylationLVSKRDGNSSLIAAV
HHHCCCCCCHHHEEE		32.49UniProtKB CARBOHYD
1064N-linked_GlycosylationVQRRPLKNRTDFLVP
CCCCCCCCCCCCHHH		60.82UniProtKB CARBOHYD
1101PhosphorylationRKRRKPGSHTHSASE
HHCCCCCCCCCCCCC		33.4729116813
1103PhosphorylationRRKPGSHTHSASEDN
CCCCCCCCCCCCCCC		21.1527794612
1105PhosphorylationKPGSHTHSASEDNTT
CCCCCCCCCCCCCCC		34.3529116813
1107PhosphorylationGSHTHSASEDNTTNN
CCCCCCCCCCCCCHH		48.8029116813
1111PhosphorylationHSASEDNTTNNVREQ
CCCCCCCCCHHHHHH		43.1323312004
1112PhosphorylationSASEDNTTNNVREQL
CCCCCCCCHHHHHHH		30.9323312004
1123UbiquitinationREQLNQIKNPIEKHG
HHHHHHCCCHHHHCC		47.0821890473
1123UbiquitinationREQLNQIKNPIEKHG
HHHHHHCCCHHHHCC		47.0821890473
1128UbiquitinationQIKNPIEKHGANTVP
HCCCHHHHCCCCCCC		48.32-
1137UbiquitinationGANTVPIKDYENKNS
CCCCCCCCCCCCCCC		48.46-
1139PhosphorylationNTVPIKDYENKNSKM
CCCCCCCCCCCCCCC		19.1928796482
1145AcetylationDYENKNSKMSKIRTH
CCCCCCCCCHHHHCC		57.4912653559
1148AcetylationNKNSKMSKIRTHNSE
CCCCCCHHHHCCCCC		32.4812653569
1151PhosphorylationSKMSKIRTHNSEVEE
CCCHHHHCCCCCCCH		28.9629514088
1154PhosphorylationSKIRTHNSEVEEDDM
HHHHCCCCCCCHHHH		35.1028985074
1176PhosphorylationRFAKQPAYTLVDREE
HHHCCCCEEEECCCC		13.8025159151
1177PhosphorylationFAKQPAYTLVDREEK
HHCCCCEEEECCCCC		23.55-
1189PhosphorylationEEKPPNGTPTKHPNW
CCCCCCCCCCCCCCC		34.1325159151
1199UbiquitinationKHPNWTNKQDNRDLE
CCCCCCCCCCCCCHH		52.21-
1207PhosphorylationQDNRDLESAQSLNRM
CCCCCHHHHHHHHCH		38.6222167270
1210PhosphorylationRDLESAQSLNRMEYI
CCHHHHHHHHCHHHC		27.5922167270
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseMIB1Q86YT6
PMID:25747658
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of JAG1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of JAG1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NOTC2_HUMANNOTCH2physical
11346656
NOTC2_HUMANNOTCH2physical
10551863
NOTC1_HUMANNOTCH1physical
20720151
MIB1_HUMANMIB1physical
20720151
HGS_HUMANHGSphysical
20720151
NOTC1_HUMANNOTCH1physical
21820430
FBXW7_HUMANFBXW7physical
21820430
MIB1_HUMANMIB1physical
25747658
Drug and Disease Associations
Kegg Disease
H00549 Tetralogy of Fallot
H00551 Alagille syndrome
OMIM Disease
118450Alagille syndrome 1 (ALGS1)
187500Tetralogy of Fallot (TOF)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of JAG1_HUMAN

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Related Literatures of Post-Translational Modification

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