dbPTM

ANX13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ANX13_HUMAN
UniProt AC	P27216
Protein Name	Annexin A13
Gene Name	ANXA13
Organism	Homo sapiens (Human).
Sequence Length	316
Subcellular Localization	Cell membrane. Associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes.
Protein Description
Protein Sequence	MGNRHAKASSPQGFDVDRDAKKLNKACKGMGTNEAAIIEILSGRTSDERQQIKQKYKATYGKELEEVLKSELSGNFEKTALALLDRPSEYAARQLQKAMKGLGTDESVLIEVLCTRTNKEIIAIKEAYQRLFDRSLESDVKGDTSGNLKKILVSLLQANRNEGDDVDKDLAGQDAKDLYDAGEGRWGTDELAFNEVLAKRSYKQLRATFQAYQILIGKDIEEAIEEETSGDLQKAYLTLVRCAQDCEDYFAERLYKSMKGAGTDEETLIRIVVTRAEVDLQGIKAKFQEKYQKSLSDMVRSDTSGDFRKLLVALLH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGNRHAKAS ------CCCCCCCCC	39.62	-
2	Myristoylation	------MGNRHAKAS ------CCCCCCCCC	39.62	30610115
9	Phosphorylation	GNRHAKASSPQGFDV CCCCCCCCCCCCCCC	41.67	27696853
10	Phosphorylation	NRHAKASSPQGFDVD CCCCCCCCCCCCCCC	26.54	26657352
10 (in isoform 2)	Phosphorylation	-	26.54	26657352
23 (in isoform 2)	Phosphorylation	-	8.61	26657352
26 (in isoform 2)	Phosphorylation	-	10.12	26657352
51 (in isoform 2)	Phosphorylation	-	51.58	24275569
60	Phosphorylation	KQKYKATYGKELEEV HHHHHHHHHHHHHHH	30.93	46164651
78	Methylation	ELSGNFEKTALALLD HHCCCHHHHHHHHHC	34.65	-
90	Phosphorylation	LLDRPSEYAARQLQK HHCCHHHHHHHHHHH	15.19	20560743
115	Phosphorylation	VLIEVLCTRTNKEII HHHHHHHCCCCCHHH	36.05	23532336
128	Phosphorylation	IIAIKEAYQRLFDRS HHHHHHHHHHHHHCC	8.68	20560749
179	Phosphorylation	GQDAKDLYDAGEGRW CCCHHHHHHCCCCCC	17.55	21253578
255	Phosphorylation	DYFAERLYKSMKGAG HHHHHHHHHHHCCCC	13.77	11906311
274	Phosphorylation	TLIRIVVTRAEVDLQ HHHHHHEEHHHHCHH	17.17	50565697
304	Phosphorylation	DMVRSDTSGDFRKLL HHHHCCCCCHHHHHH	41.16	46164645

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4	P46934	PMID:10871286

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ANX13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ANX13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
NEDD4_HUMAN	NEDD4	physical	10871286

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ANX13_HUMAN

Related Literatures of Post-Translational Modification

Myristoylation
Reference	PubMed
"A strategy for isolation of cDNAs encoding proteins affecting humanintestinal epithelial cell growth and differentiation:characterization of a novel gut-specific N-myristoylated annexin."; Wice B.M., Gordon J.I.; J. Cell Biol. 116:405-422(1992). Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), AND MYRISTOYLATION AT GLY-2.	1530946 [Abstract]