PO2F3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PO2F3_HUMAN
• UniProt AC: Q9UKI9
• Protein Name: POU domain, class 2, transcription factor 3
• Gene Name: POU2F3
• Organism: Homo sapiens (Human).
• Sequence Length: 436
• Subcellular Localization: Nucleus.
• Protein Description: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a number of genes such as SPRR2A or placental lactogen..
• Protein Sequence: MVNLESMHTDIKMSGDVADSTDARSTLSQVEPGNDRNGLDFNRQIKTEDLSDSLQQTLSHRPCHLSQGPAMMSGNQMSGLNASPCQDMASLHPLQQLVLVPGHLQSVSQFLLSQTQPGQQGLQPNLLPFPQQQSGLLLPQTGPGLASQAFGHPGLPGSSLEPHLEASQHLPVPKHLPSSGGADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSVSTPSSYPSLSEVFGRKRKKRTSIETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPVATPIKPPVYNSRLVSPSGSLGPLSVPPVHSTMPGTVTSSCSPGNNSRPSSPGSGLHASSPTASQNNSKAAVNSASSFNSSGSWYRWNHSTYLH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	MHTDIKMSGDVADST HCCCCCCCCCCCCCC	27.17	-
20	Phosphorylation	MSGDVADSTDARSTL CCCCCCCCCCCCHHH	20.60	-
21	Phosphorylation	SGDVADSTDARSTLS CCCCCCCCCCCHHHH	33.94	23532336
28	Phosphorylation	TDARSTLSQVEPGND CCCCHHHHHCCCCCC	32.06	26714015
166	Ubiquitination	SLEPHLEASQHLPVP CCCCCCCHHHCCCCC	22.35	23000965
171	Ubiquitination	LEASQHLPVPKHLPS CCHHHCCCCCCCCCC	37.94	23000965
178	Phosphorylation	PVPKHLPSSGGADEP CCCCCCCCCCCCCCC	48.23	24719451
195	Ubiquitination	LEELEKFAKTFKQRR HHHHHHHHHHHHHHH	22.50	23000965
199	Ubiquitination	EKFAKTFKQRRIKLG HHHHHHHHHHHHHCC	48.39	23000965
200	Ubiquitination	KFAKTFKQRRIKLGF HHHHHHHHHHHHCCC	35.38	23000965
200 (in isoform 3)	Ubiquitination	-	35.38	-
201	Ubiquitination	FAKTFKQRRIKLGFT HHHHHHHHHHHCCCC	42.77	23000965
204	Ubiquitination	TFKQRRIKLGFTQGD HHHHHHHHCCCCCHH	40.52	23000965
206	Ubiquitination	KQRRIKLGFTQGDVG HHHHHHCCCCCHHHH	20.67	23000965
214 (in isoform 3)	Ubiquitination	-	2.74	-
218	Ubiquitination	DVGLAMGKLYGNDFS HHHHHHHHHHCCCCC	26.00	-
220	Ubiquitination	GLAMGKLYGNDFSQT HHHHHHHHCCCCCHH	19.85	2190698
225	Phosphorylation	KLYGNDFSQTTISRF HHHCCCCCHHHHHHH	29.49	28555341
236 (in isoform 3)	Ubiquitination	-	40.46	-
238	Phosphorylation	RFEALNLSFKNMCKL HHHHHCCHHHHHHHH	32.85	25159151
258	Phosphorylation	KWLNDAESSPSDPSV HHHHCCCCCCCCCCC	49.63	-
259	Phosphorylation	WLNDAESSPSDPSVS HHHCCCCCCCCCCCC	21.67	-
286	Phosphorylation	GRKRKKRTSIETNIR CCCCCCCCCCHHHHH	42.83	26657352
287	Phosphorylation	RKRKKRTSIETNIRL CCCCCCCCCHHHHHH	23.59	25159151
290	Phosphorylation	KKRTSIETNIRLTLE CCCCCCHHHHHHHHH	33.99	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PO2F3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PO2F3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PO2F3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PO2F3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.