UniProt ID | HXB6_HUMAN | |
---|---|---|
UniProt AC | P17509 | |
Protein Name | Homeobox protein Hox-B6 | |
Gene Name | HOXB6 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 224 | |
Subcellular Localization | Nucleus. | |
Protein Description | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.. | |
Protein Sequence | MSSYFVNSTFPVTLASGQESFLGQLPLYSSGYADPLRHYPAPYGPGPGQDKGFATSSYYPPAGGGYGRAAPCDYGPAPAFYREKESACALSGADEQPPFHPEPRKSDCAQDKSVFGETEEQKCSTPVYPWMQRMNSCNSSSFGPSGRRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKESKLLSASQLSAEEEEEKQAE | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
74 | Phosphorylation | GRAAPCDYGPAPAFY CCCCCCCCCCCCHHH | 31.55 | 29978859 | |
86 | Phosphorylation | AFYREKESACALSGA HHHCHHHCCCHHCCC | 39.45 | 29449344 | |
91 | Phosphorylation | KESACALSGADEQPP HHCCCHHCCCCCCCC | 17.26 | 29449344 | |
125 | Phosphorylation | TEEQKCSTPVYPWMQ CCHHHCCCCCHHHHH | 26.66 | 24719451 | |
136 | Phosphorylation | PWMQRMNSCNSSSFG HHHHHHHCCCCCCCC | 12.82 | 28857561 | |
139 | Phosphorylation | QRMNSCNSSSFGPSG HHHHCCCCCCCCCCC | 31.52 | 24247654 | |
158 | Phosphorylation | QTYTRYQTLELEKEF CEEEEEEEEHHHHHH | 17.17 | 29449344 | |
167 | Phosphorylation | ELEKEFHYNRYLTRR HHHHHHHHHHHHHHH | 13.47 | 29449344 | |
169 | Methylation | EKEFHYNRYLTRRRR HHHHHHHHHHHHHHH | 22.22 | - | |
170 | Phosphorylation | KEFHYNRYLTRRRRI HHHHHHHHHHHHHHH | 14.59 | 29449344 | |
172 | Phosphorylation | FHYNRYLTRRRRIEI HHHHHHHHHHHHHHH | 17.13 | 29449344 | |
205 | Phosphorylation | RMKWKKESKLLSASQ CCCHHHHHHHHCHHH | 37.17 | 29449344 | |
209 | Phosphorylation | KKESKLLSASQLSAE HHHHHHHCHHHCCHH | 35.99 | 22617229 | |
211 | Phosphorylation | ESKLLSASQLSAEEE HHHHHCHHHCCHHHH | 28.42 | 17525332 | |
214 | Phosphorylation | LLSASQLSAEEEEEK HHCHHHCCHHHHHHH | 26.46 | 19664994 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HXB6_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HXB6_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HXB6_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
SAT1_HUMAN | SAT1 | physical | 16189514 | |
PLS1_HUMAN | PLSCR1 | physical | 16189514 | |
K1C15_HUMAN | KRT15 | physical | 16189514 | |
TCF21_HUMAN | TCF21 | physical | 20211142 | |
TCAL1_HUMAN | TCEAL1 | physical | 20211142 | |
ALX4_HUMAN | ALX4 | physical | 20211142 | |
CBP_HUMAN | CREBBP | physical | 15269212 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214, AND MASSSPECTROMETRY. | |
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214, AND MASSSPECTROMETRY. | |
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211 AND SER-214, ANDMASS SPECTROMETRY. |