HXB6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXB6_HUMAN
• UniProt AC: P17509
• Protein Name: Homeobox protein Hox-B6
• Gene Name: HOXB6
• Organism: Homo sapiens (Human).
• Sequence Length: 224
• Subcellular Localization: Nucleus.
• Protein Description: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis..
• Protein Sequence: MSSYFVNSTFPVTLASGQESFLGQLPLYSSGYADPLRHYPAPYGPGPGQDKGFATSSYYPPAGGGYGRAAPCDYGPAPAFYREKESACALSGADEQPPFHPEPRKSDCAQDKSVFGETEEQKCSTPVYPWMQRMNSCNSSSFGPSGRRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKESKLLSASQLSAEEEEEKQAE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
74	Phosphorylation	GRAAPCDYGPAPAFY CCCCCCCCCCCCHHH	31.55	29978859
86	Phosphorylation	AFYREKESACALSGA HHHCHHHCCCHHCCC	39.45	29449344
91	Phosphorylation	KESACALSGADEQPP HHCCCHHCCCCCCCC	17.26	29449344
125	Phosphorylation	TEEQKCSTPVYPWMQ CCHHHCCCCCHHHHH	26.66	24719451
136	Phosphorylation	PWMQRMNSCNSSSFG HHHHHHHCCCCCCCC	12.82	28857561
139	Phosphorylation	QRMNSCNSSSFGPSG HHHHCCCCCCCCCCC	31.52	24247654
158	Phosphorylation	QTYTRYQTLELEKEF CEEEEEEEEHHHHHH	17.17	29449344
167	Phosphorylation	ELEKEFHYNRYLTRR HHHHHHHHHHHHHHH	13.47	29449344
169	Methylation	EKEFHYNRYLTRRRR HHHHHHHHHHHHHHH	22.22	-
170	Phosphorylation	KEFHYNRYLTRRRRI HHHHHHHHHHHHHHH	14.59	29449344
172	Phosphorylation	FHYNRYLTRRRRIEI HHHHHHHHHHHHHHH	17.13	29449344
205	Phosphorylation	RMKWKKESKLLSASQ CCCHHHHHHHHCHHH	37.17	29449344
209	Phosphorylation	KKESKLLSASQLSAE HHHHHHHCHHHCCHH	35.99	22617229
211	Phosphorylation	ESKLLSASQLSAEEE HHHHHCHHHCCHHHH	28.42	17525332
214	Phosphorylation	LLSASQLSAEEEEEK HHCHHHCCHHHHHHH	26.46	19664994

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HXB6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXB6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXB6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SAT1_HUMAN	SAT1	physical	16189514
PLS1_HUMAN	PLSCR1	physical	16189514
K1C15_HUMAN	KRT15	physical	16189514
TCF21_HUMAN	TCF21	physical	20211142
TCAL1_HUMAN	TCEAL1	physical	20211142
ALX4_HUMAN	ALX4	physical	20211142
CBP_HUMAN	CREBBP	physical	15269212

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214, AND MASSSPECTROMETRY.
PubMed: 19369195

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214, AND MASSSPECTROMETRY.
PubMed: 19413330

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211 AND SER-214, ANDMASS SPECTROMETRY.
PubMed: 17525332