HXB6_HUMAN - dbPTM
HXB6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HXB6_HUMAN
UniProt AC P17509
Protein Name Homeobox protein Hox-B6
Gene Name HOXB6
Organism Homo sapiens (Human).
Sequence Length 224
Subcellular Localization Nucleus.
Protein Description Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis..
Protein Sequence MSSYFVNSTFPVTLASGQESFLGQLPLYSSGYADPLRHYPAPYGPGPGQDKGFATSSYYPPAGGGYGRAAPCDYGPAPAFYREKESACALSGADEQPPFHPEPRKSDCAQDKSVFGETEEQKCSTPVYPWMQRMNSCNSSSFGPSGRRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKESKLLSASQLSAEEEEEKQAE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
74PhosphorylationGRAAPCDYGPAPAFY
CCCCCCCCCCCCHHH
31.5529978859
86PhosphorylationAFYREKESACALSGA
HHHCHHHCCCHHCCC
39.4529449344
91PhosphorylationKESACALSGADEQPP
HHCCCHHCCCCCCCC
17.2629449344
125PhosphorylationTEEQKCSTPVYPWMQ
CCHHHCCCCCHHHHH
26.6624719451
136PhosphorylationPWMQRMNSCNSSSFG
HHHHHHHCCCCCCCC
12.8228857561
139PhosphorylationQRMNSCNSSSFGPSG
HHHHCCCCCCCCCCC
31.5224247654
158PhosphorylationQTYTRYQTLELEKEF
CEEEEEEEEHHHHHH
17.1729449344
167PhosphorylationELEKEFHYNRYLTRR
HHHHHHHHHHHHHHH
13.4729449344
169MethylationEKEFHYNRYLTRRRR
HHHHHHHHHHHHHHH
22.22-
170PhosphorylationKEFHYNRYLTRRRRI
HHHHHHHHHHHHHHH
14.5929449344
172PhosphorylationFHYNRYLTRRRRIEI
HHHHHHHHHHHHHHH
17.1329449344
205PhosphorylationRMKWKKESKLLSASQ
CCCHHHHHHHHCHHH
37.1729449344
209PhosphorylationKKESKLLSASQLSAE
HHHHHHHCHHHCCHH
35.9922617229
211PhosphorylationESKLLSASQLSAEEE
HHHHHCHHHCCHHHH
28.4217525332
214PhosphorylationLLSASQLSAEEEEEK
HHCHHHCCHHHHHHH
26.4619664994

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HXB6_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HXB6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HXB6_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SAT1_HUMANSAT1physical
16189514
PLS1_HUMANPLSCR1physical
16189514
K1C15_HUMANKRT15physical
16189514
TCF21_HUMANTCF21physical
20211142
TCAL1_HUMANTCEAL1physical
20211142
ALX4_HUMANALX4physical
20211142
CBP_HUMANCREBBPphysical
15269212

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HXB6_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214, AND MASSSPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214, AND MASSSPECTROMETRY.
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211 AND SER-214, ANDMASS SPECTROMETRY.

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