TCAL1_HUMAN - dbPTM
TCAL1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TCAL1_HUMAN
UniProt AC Q15170
Protein Name Transcription elongation factor A protein-like 1
Gene Name TCEAL1
Organism Homo sapiens (Human).
Sequence Length 157
Subcellular Localization Nucleus.
Protein Description May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly..
Protein Sequence MDKPRKENEEEPQSRPRPMRRGLRWSTLPKSSPPRSSLRRSSPRRRSSFLRSSCLSSCLRCSSRRTPSAGLSRKDLFEGRPPMEQPPCGVGKHKLEEGSFKERLARSRPQFRGDIHGRNLSNEEMIQAADELEEMKRVRNKLMIMHWKAKRSRPYPI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
14 (in isoform 2)Phosphorylation-55.77-
18 (in isoform 2)Phosphorylation-24.2626437602
27PhosphorylationRRGLRWSTLPKSSPP
CCCCCCCCCCCCCCC		39.87-
28 (in isoform 2)Phosphorylation-4.1420201521
28PhosphorylationRGLRWSTLPKSSPPR
CCCCCCCCCCCCCCC		4.1417081983
31PhosphorylationRWSTLPKSSPPRSSL
CCCCCCCCCCCCHHH		46.257592688
32PhosphorylationWSTLPKSSPPRSSLR
CCCCCCCCCCCHHHC		45.087592688
33 (in isoform 2)Phosphorylation-35.1023909892
36PhosphorylationPKSSPPRSSLRRSSP
CCCCCCCHHHCCCCC		39.2310051408
37PhosphorylationKSSPPRSSLRRSSPR
CCCCCCHHHCCCCCC		27.4610051408
38 (in isoform 2)Phosphorylation-5.7823909892
39 (in isoform 2)Phosphorylation-38.0823909892
41PhosphorylationPRSSLRRSSPRRRSS
CCHHHCCCCCCHHHH		37.9617081983
42PhosphorylationRSSLRRSSPRRRSSF
CHHHCCCCCCHHHHH		22.1817081983
43 (in isoform 2)Phosphorylation-34.7423909892
44 (in isoform 2)Phosphorylation-48.9023909892
47PhosphorylationRSSPRRRSSFLRSSC
CCCCCHHHHHHHHHH		24.517592688
48PhosphorylationSSPRRRSSFLRSSCL
CCCCHHHHHHHHHHH		26.8724719451
52PhosphorylationRRSSFLRSSCLSSCL
HHHHHHHHHHHHHHH		27.7929083192
53PhosphorylationRSSFLRSSCLSSCLR
HHHHHHHHHHHHHHH		16.7929083192
56PhosphorylationFLRSSCLSSCLRCSS
HHHHHHHHHHHHHHC		24.2729083192
57PhosphorylationLRSSCLSSCLRCSSR
HHHHHHHHHHHHHCC		12.2929083192
66PhosphorylationLRCSSRRTPSAGLSR
HHHHCCCCCCCCCCH		22.0823312004
68PhosphorylationCSSRRTPSAGLSRKD
HHCCCCCCCCCCHHH		34.0623312004
92MethylationQPPCGVGKHKLEEGS
CCCCCCCCCCCCCCC		34.85115981219
94SumoylationPCGVGKHKLEEGSFK
CCCCCCCCCCCCCHH		62.17-
96UbiquitinationGVGKHKLEEGSFKER
CCCCCCCCCCCHHHH		66.1829967540
99PhosphorylationKHKLEEGSFKERLAR
CCCCCCCCHHHHHHH		36.1027251275
101MethylationKLEEGSFKERLARSR
CCCCCCHHHHHHHCC		43.55115981213
103UbiquitinationEEGSFKERLARSRPQ
CCCCHHHHHHHCCCC		33.9532015554
112MethylationARSRPQFRGDIHGRN
HHCCCCCCCCCCCCC		36.31115916981
121PhosphorylationDIHGRNLSNEEMIQA
CCCCCCCCHHHHHHH		45.8329978859
136UbiquitinationADELEEMKRVRNKLM
HHHHHHHHHHHHHHH		51.53-
138UbiquitinationELEEMKRVRNKLMIM
HHHHHHHHHHHHHHH		7.0732015554
138 (in isoform 2)Ubiquitination-7.07-
155PhosphorylationKAKRSRPYPI-----
HCCCCCCCCC-----		16.677592688
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TCAL1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
36SPhosphorylation

7592688
37SPhosphorylation

7592688
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TCAL1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBP11_HUMANUSP11physical
17353931
HS74L_HUMANHSPA4Lphysical
17353931
SSRG_HUMANSSR3physical
17353931
2ABA_HUMANPPP2R2Aphysical
17353931
ELOC_HUMANTCEB1physical
19615732
UBP7_HUMANUSP7physical
19615732
UBP11_HUMANUSP11physical
19615732
CUL2_HUMANCUL2physical
19615732
GUAA_HUMANGMPSphysical
19615732
PDCD5_HUMANPDCD5physical
19615732
TIPIN_HUMANTIPINphysical
19615732
FEM1A_HUMANFEM1Aphysical
19615732
KDM3A_HUMANKDM3Aphysical
19615732
2ABD_HUMANPPP2R2Dphysical
19615732
FEM1C_HUMANFEM1Cphysical
19615732
TCAL4_HUMANTCEAL4physical
19615732
TCAL2_HUMANTCEAL2physical
19615732
UBP11_HUMANUSP11physical
26186194
UBP4_HUMANUSP4physical
26186194
EYA3_HUMANEYA3physical
26186194
KDM3A_HUMANKDM3Aphysical
26186194
HXB9_HUMANHOXB9physical
26186194
MCMBP_HUMANMCMBPphysical
26186194
UBP7_HUMANUSP7physical
26186194
POGK_HUMANPOGKphysical
26186194
TRI25_HUMANTRIM25physical
26186194
ZN703_HUMANZNF703physical
26186194
ZN503_HUMANZNF503physical
26186194
UHRF1_HUMANUHRF1physical
26186194
ZUFSP_HUMANZUFSPphysical
26186194
STAT3_HUMANSTAT3physical
26186194
SAS6_HUMANSASS6physical
26186194
PTN11_HUMANPTPN11physical
26186194
UB2Q1_HUMANUBE2Q1physical
26186194
ZKSC4_HUMANZKSCAN4physical
26186194
CHK1_HUMANCHEK1physical
26186194
CI040_HUMANC9orf40physical
26186194
FAF1_HUMANFAF1physical
26186194
DTL_HUMANDTLphysical
26186194
CDCA2_HUMANCDCA2physical
26186194
TYDP2_HUMANTDP2physical
26186194
KDM3A_HUMANKDM3Aphysical
28514442
UHRF1_HUMANUHRF1physical
28514442
EYA3_HUMANEYA3physical
28514442
POGK_HUMANPOGKphysical
28514442
STAT3_HUMANSTAT3physical
28514442
UBP4_HUMANUSP4physical
28514442
FAF1_HUMANFAF1physical
28514442
TYDP2_HUMANTDP2physical
28514442
ZUFSP_HUMANZUFSPphysical
28514442
TRI25_HUMANTRIM25physical
28514442
CDCA2_HUMANCDCA2physical
28514442
UBP11_HUMANUSP11physical
28514442
DTL_HUMANDTLphysical
28514442
UB2Q1_HUMANUBE2Q1physical
28514442
CHK1_HUMANCHEK1physical
28514442
SAS6_HUMANSASS6physical
28514442
HXB9_HUMANHOXB9physical
28514442
UBP7_HUMANUSP7physical
28514442
ZN703_HUMANZNF703physical
28514442
CI040_HUMANC9orf40physical
28514442
PTN11_HUMANPTPN11physical
28514442
ZKSC4_HUMANZKSCAN4physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TCAL1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The Ser36-Ser37 pair in HeLa nuclear protein p21/SIIR mediatesSer/Thr phosphorylation and is essential for Rous sarcoma virus longterminal repeat repression.";
Yeh C.-H., Zong W.-X., Shatkin A.J.;
J. Biol. Chem. 270:25313-25315(1995).
Cited for: PHOSPHORYLATION AT SER-31; SER-32; SER-36; SER-37; SER-41; SER-42;SER-47 AND SER-48, AND MUTAGENESIS OF 31-SER-SER-32; 36-SER-SER-37;41-SER-SER-42 AND 47-SER-SER-48.

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