CI040_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CI040_HUMAN
• UniProt AC: Q8IXQ3
• Protein Name: Uncharacterized protein C9orf40
• Gene Name: C9orf40
• Organism: Homo sapiens (Human).
• Sequence Length: 194
• Protein Sequence: MAKRRAAEPVTFHVPWKRLLLCDFAEQPPPPPLWIRPPGVAHAGQLLGVPEQHRKRKIDAGTMAEPSASPSKRRDSGDNSAPSGQEREDHGLETGDPPLPPPPVLPGPGEELPGARLPGGGGDDGAGRAGPPRGDWGVASRQHNEEFWQYNTFQYWRNPLPPIDLADIEDLSEDTLTEATLQGRNEGAEVDMES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Acetylation	VTFHVPWKRLLLCDF EEEECCHHHEEECCC	27.39	25953088
17	Ubiquitination	VTFHVPWKRLLLCDF EEEECCHHHEEECCC	27.39	21890473
62	Phosphorylation	KRKIDAGTMAEPSAS CCCCCCCCCCCCCCC	18.22	23927012
67	Phosphorylation	AGTMAEPSASPSKRR CCCCCCCCCCCCCCC	32.65	23401153
69	Phosphorylation	TMAEPSASPSKRRDS CCCCCCCCCCCCCCC	33.76	19664994
71	Phosphorylation	AEPSASPSKRRDSGD CCCCCCCCCCCCCCC	35.98	30266825
72	Ubiquitination	EPSASPSKRRDSGDN CCCCCCCCCCCCCCC	55.63	-
76	Phosphorylation	SPSKRRDSGDNSAPS CCCCCCCCCCCCCCC	46.35	23401153
80	Phosphorylation	RRDSGDNSAPSGQER CCCCCCCCCCCCCHH	46.42	30278072
83	Phosphorylation	SGDNSAPSGQEREDH CCCCCCCCCCHHHHC	53.47	23927012
94	Phosphorylation	REDHGLETGDPPLPP HHHCCCCCCCCCCCC	52.51	28464451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CI040_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CI040_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CI040_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CI040_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69, AND MASSSPECTROMETRY.
PubMed: 19690332

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69, AND MASSSPECTROMETRY.
PubMed: 19413330

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69, AND MASSSPECTROMETRY.
PubMed: 18691976

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76, AND MASSSPECTROMETRY.
PubMed: 17081983