| UniProt ID | ZUFSP_HUMAN | |
|---|---|---|
| UniProt AC | Q96AP4 | |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase ZUFSP | |
| Gene Name | ZUFSP | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 578 | |
| Subcellular Localization | Cytoplasm . Nucleus . Mostly present in the nuclear fraction. Localizes to DNA lesions. | |
| Protein Description | Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. [PubMed: 29576528] | |
| Protein Sequence | MLSCNICGETVTSEPDMKAHLIVHMESEIICPFCKLSGVNYDEMCFHIETAHFEQNTLERNFERINTVQYGTSDNKKDNTLQCGMEVNSSILSGCASNHPKNSAQNLTKDSTLKHEGFYSENLTESRKFLKSREKQSSLTEIKGSVYETTYSPPECPFCGKIEEHSEDMETHVKTKHANLLDIPLEDCDQPLYDCPMCGLICTNYHILQEHVDLHLEENSFQQGMDRVQCSGDLQLAHQLQQEEDRKRRSEESRQEIEEFQKLQRQYGLDNSGGYKQQQLRNMEIEVNRGRMPPSEFHRRKADMMESLALGFDDGKTKTSGIIEALHRYYQNAATDVRRVWLSSVVDHFHSSLGDKGWGCGYRNFQMLLSSLLQNDAYNDCLKGMLIPCIPKIQSMIEDAWKEGFDPQGASQLNNRLQGTKAWIGACEVYILLTSLRVKCHIVDFHKSTGPLGTHPRLFEWILNYYSSEGEGSPKVVCTSKPPIYLQHQGHSRTVIGIEEKKNRTLCLLILDPGCPSREMQKLLKQDIEASSLKQLRKSMGNLKHKQYQILAVEGALSLEEKLARRQASQVFTAEKIP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 (in isoform 2) | Ubiquitination | - | 3.61 | 21890473 | |
| 15 (in isoform 2) | Ubiquitination | - | 46.92 | 21890473 | |
| 76 (in isoform 1) | Ubiquitination | - | 67.50 | 21890473 | |
| 109 (in isoform 1) | Ubiquitination | - | 53.50 | 21890473 | |
| 114 (in isoform 1) | Ubiquitination | - | 39.43 | 21890473 | |
| 262 (in isoform 1) | Ubiquitination | - | 52.48 | 21890473 | |
| 276 (in isoform 1) | Ubiquitination | - | 44.92 | 21890473 | |
| 301 (in isoform 1) | Ubiquitination | - | 49.01 | 21890473 | |
| 318 (in isoform 1) | Ubiquitination | - | 44.15 | 21890473 | |
| 356 (in isoform 1) | Ubiquitination | - | 55.56 | 21890473 | |
| 525 (in isoform 1) | Ubiquitination | - | 57.26 | 21890473 | |
| 534 (in isoform 1) | Ubiquitination | - | 49.59 | 21890473 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ZUFSP_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ZUFSP_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ZUFSP_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ANM5_HUMAN | PRMT5 | physical | 23455924 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Acetylation | |
| Reference | PubMed |
| "Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-262, AND MASS SPECTROMETRY. | |
