FEM1C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FEM1C_HUMAN
• UniProt AC: Q96JP0
• Protein Name: Protein fem-1 homolog C
• Gene Name: FEM1C
• Organism: Homo sapiens (Human).
• Sequence Length: 617
• Subcellular Localization: Cytoplasm.
• Protein Description: Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit..
• Protein Sequence: MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVLEIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGHIPEKLETFVSLHR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDLKTAVF -------CCHHHHHH	14.20	22814378
4	Ubiquitination	----MDLKTAVFNAA ----CCHHHHHHHHH	30.12	-
20	Phosphorylation	DGKLRLLTKLLASKS HCHHHHHHHHHHCCC	25.00	23898821
27	Phosphorylation	TKLLASKSKEEVSSL HHHHHCCCHHHHHHH	42.69	26434776
28	Ubiquitination	KLLASKSKEEVSSLI HHHHCCCHHHHHHHH	62.72	29967540
32	Phosphorylation	SKSKEEVSSLISEKT CCCHHHHHHHHHHHC	23.78	26434776
33	Phosphorylation	KSKEEVSSLISEKTN CCHHHHHHHHHHHCC	34.59	26434776
36	Phosphorylation	EEVSSLISEKTNGAT HHHHHHHHHHCCCCC	38.03	24719451
39	Phosphorylation	SSLISEKTNGATPLL HHHHHHHCCCCCHHH	34.53	26434776
43	Phosphorylation	SEKTNGATPLLMAAR HHHCCCCCHHHHHHH	18.83	26434776
114	Ubiquitination	ASVNNTTLTNSTPLR CCCCCCCCCCCCCCC	3.93	21890473
115	Phosphorylation	SVNNTTLTNSTPLRA CCCCCCCCCCCCCCH	25.65	22798277
117	Ubiquitination	NNTTLTNSTPLRAAC CCCCCCCCCCCCHHH	26.60	22817900
117	Phosphorylation	NNTTLTNSTPLRAAC CCCCCCCCCCCCHHH	26.60	24719451
118	Ubiquitination	NTTLTNSTPLRAACF CCCCCCCCCCCHHHH	28.54	22817900
145	Phosphorylation	HKADLEVSNRHGHTC CCCCCEEECCCCCEE	20.83	27499020
171	Ubiquitination	IAQYLLEKGADVNRK HHHHHHHCCCCCCCC	60.41	29967540
202	Ubiquitination	LDIMKMLLMYCAKME HHHHHHHHHHHHHHC	1.74	27667366
267	Ubiquitination	RDLLGALKYWKKAMN HHHHHHHHHHHHHHH	48.83	21906983
268	Phosphorylation	DLLGALKYWKKAMNM HHHHHHHHHHHHHHC	24.26	-
270	Ubiquitination	LGALKYWKKAMNMRY HHHHHHHHHHHHCCC	27.80	22817900
271	Ubiquitination	GALKYWKKAMNMRYS HHHHHHHHHHHCCCC	38.43	22817900
286	Ubiquitination	DRTNIISKPVPQTLI CCCCCCCCCCCCHHH	39.36	-
313	Ubiquitination	EELEGLIADPDEMRM HHHCCCCCCHHHHHH	27.59	27667366
333	Phosphorylation	RERILGPSHPDTSYY HHHHHCCCCCCCCEE	45.94	-
355	Ubiquitination	YADSGNFKRCINLWK EECCCCHHHHHHHHH	50.81	27667366
363	Phosphorylation	RCINLWKYALDMQQS HHHHHHHHHHHHHHC	10.79	21060948
382	Phosphorylation	LSPMTASSLLSFAEL CCCCCHHHHHHHHHH	30.76	21060948
385	Phosphorylation	MTASSLLSFAELFSF CCHHHHHHHHHHHHH	27.92	21060948
417	Ubiquitination	DLMGILCKSVLEIER HHHHHHHHHHHHHHH	39.90	-
418	Ubiquitination	LMGILCKSVLEIERA HHHHHHHHHHHHHHH	30.82	22817900
422	Ubiquitination	LCKSVLEIERAIKQT HHHHHHHHHHHHHHC	3.67	22817900
466	Ubiquitination	LEQDHFKKQTIYRFL CCCCHHCHHHHHHHH	52.29	27667366
470	Phosphorylation	HFKKQTIYRFLKLHP HHCHHHHHHHHHCCC	9.94	25884760
474	Ubiquitination	QTIYRFLKLHPRGKN HHHHHHHHCCCCCCC	41.88	-
492	Ubiquitination	PLHLAVDKNTTCVGR CEEEEECCCCCCCCC	49.98	29967540
494	Phosphorylation	HLAVDKNTTCVGRYP EEEECCCCCCCCCCC	27.58	-
561	Ubiquitination	FDATNLHKQTASDLL CCCCCCCHHHHHHHC	53.13	29967540
571	Ubiquitination	ASDLLDEKEIAKNLI HHHHCCHHHHHHHHC	54.83	21906983
575	Ubiquitination	LDEKEIAKNLIQPIN CCHHHHHHHHCCCCC	58.93	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FEM1C_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FEM1C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FEM1C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RPGR1_HUMAN	RPGRIP1	physical	25416956
LZTS2_HUMAN	LZTS2	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.