MYB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYB_HUMAN
• UniProt AC: P10242
• Protein Name: Transcriptional activator Myb
• Gene Name: MYB
• Organism: Homo sapiens (Human).
• Sequence Length: 640
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells..
• Protein Sequence: MARRPRHSIYSSDEDDEDFEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQESSKASQPAVATSFQKNSHLMGFAQAPPTAQLPATGQPTVNNDYSYYHISEAQNVSSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELELLLMSTENELKGQQVLPTQNHTCSYPGWHSTTIADHTRPHGDSAPVSCLGEHHSTPSLPADPGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSFLNTSSNHENSDLEMPSLTSTPLIGHKLTVTTPFHRDQTVKTQKENTVFRTPAIKRSILESSPRTPTPFKHALAAQEIKYGPLKMLPQTPSHLVEDLQDVIKQESDESGIVAEFQENGPPLLKKIKQEVESPTDKSGNFFCSHHWEGDSLNTQLFTQTSPVADAPNILTSSVLMAPASEDEDNVLKAFTVPKNRSLASPLQPCSSTWEPASCGKMEEQMTSSSQARKYVNAFSARTLVM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MARRPRHSIYSSDED CCCCCCCCCCCCCCC	25.22	30576142
10	Phosphorylation	RRPRHSIYSSDEDDE CCCCCCCCCCCCCCC	12.72	27251275
11	Phosphorylation	RPRHSIYSSDEDDED CCCCCCCCCCCCCCC	29.64	11522824
11 (in isoform 4)	Phosphorylation	-	29.64	27642862
12	Phosphorylation	PRHSIYSSDEDDEDF CCCCCCCCCCCCCCC	28.22	11522824
12 (in isoform 4)	Phosphorylation	-	28.22	27642862
26 (in isoform 4)	Phosphorylation	-	14.43	27642862
26	Phosphorylation	FEMCDHDYDGLLPKS CCCCCCCCCCCCCCC	14.43	27251275
44 (in isoform 4)	Phosphorylation	-	25.55	24719451
44	Phosphorylation	HLGKTRWTREEDEKL CCCCCCCCHHHHHHH	25.55	24719451
53	Ubiquitination	EEDEKLKKLVEQNGT HHHHHHHHHHHHHCC	69.10	-
53 (in isoform 4)	Ubiquitination	-	69.10	-
69	Phosphorylation	DWKVIANYLPNRTDV CHHHHHHHCCCCCCC	17.95	-
84	Ubiquitination	QCQHRWQKVLNPELI CCHHHHHHHHCHHHH	41.55	21890473
84 (in isoform 4)	Ubiquitination	-	41.55	21890473
84 (in isoform 1)	Ubiquitination	-	41.55	21890473
84 (in isoform 2)	Ubiquitination	-	41.55	21890473
84 (in isoform 3)	Ubiquitination	-	41.55	21890473
84 (in isoform 5)	Ubiquitination	-	41.55	21890473
84 (in isoform 6)	Ubiquitination	-	41.55	21890473
84	Ubiquitination	QCQHRWQKVLNPELI CCHHHHHHHHCHHHH	41.55	21890473
84	Ubiquitination	QCQHRWQKVLNPELI CCHHHHHHHHCHHHH	41.55	21890473
92	Ubiquitination	VLNPELIKGPWTKEE HHCHHHHCCCCCHHH	72.11	-
92 (in isoform 4)	Ubiquitination	-	72.11	-
97	Ubiquitination	LIKGPWTKEEDQRVI HHCCCCCHHHHHHHH	56.06	-
97 (in isoform 4)	Ubiquitination	-	56.06	-
109	Ubiquitination	RVIELVQKYGPKRWS HHHHHHHHHCCHHHH	44.70	2189047
109 (in isoform 4)	Ubiquitination	-	44.70	21890473
109 (in isoform 1)	Ubiquitination	-	44.70	21890473
109 (in isoform 2)	Ubiquitination	-	44.70	21890473
109 (in isoform 3)	Ubiquitination	-	44.70	21890473
109 (in isoform 5)	Ubiquitination	-	44.70	21890473
109 (in isoform 6)	Ubiquitination	-	44.70	21890473
109	Ubiquitination	RVIELVQKYGPKRWS HHHHHHHHHCCHHHH	44.70	21890473
109	Ubiquitination	RVIELVQKYGPKRWS HHHHHHHHHCCHHHH	44.70	21890473
113	Ubiquitination	LVQKYGPKRWSVIAK HHHHHCCHHHHHHHH	63.24	-
120	Ubiquitination	KRWSVIAKHLKGRIG HHHHHHHHHHHHHHH	38.04	-
120 (in isoform 4)	Ubiquitination	-	38.04	-
130	S-nitrosocysteine	KGRIGKQCRERWHNH HHHHHHHHHHHHHHH	5.78	-
130	S-nitrosylation	KGRIGKQCRERWHNH HHHHHHHHHHHHHHH	5.78	22178444
143	Sumoylation	NHLNPEVKKTSWTEE HHCCHHHHCCCCCHH	48.98	-
143	Sumoylation	NHLNPEVKKTSWTEE HHCCHHHHCCCCCHH	48.98	-
143	Ubiquitination	NHLNPEVKKTSWTEE HHCCHHHHCCCCCHH	48.98	-
160	Ubiquitination	RIIYQAHKRLGNRWA HHHHHHHHHHHCHHH	52.94	-
160 (in isoform 4)	Ubiquitination	-	52.94	-
171	Ubiquitination	NRWAEIAKLLPGRTD CHHHHHHHHCCCCCC	57.10	-
171 (in isoform 4)	Ubiquitination	-	57.10	-
182	Ubiquitination	GRTDNAIKNHWNSTM CCCCHHHHHHHHHHH	40.11	-
182 (in isoform 4)	Ubiquitination	-	40.11	-
192	Ubiquitination	WNSTMRRKVEQEGYL HHHHHHHHHHHCCCC	39.50	-
192 (in isoform 4)	Ubiquitination	-	39.50	-
204	Ubiquitination	GYLQESSKASQPAVA CCCCCCCCCCCCCCH	62.43	-
204 (in isoform 4)	Ubiquitination	-	62.43	-
291	Ubiquitination	YNDEDPEKEKRIKEL CCCCCHHHHHHHHHH	74.13	-
291 (in isoform 4)	Ubiquitination	-	74.13	-
293	Ubiquitination	DEDPEKEKRIKELEL CCCHHHHHHHHHHHH	71.18	-
296	Ubiquitination	PEKEKRIKELELLLM HHHHHHHHHHHHHHH	61.35	-
296 (in isoform 4)	Ubiquitination	-	61.35	-
304	Phosphorylation	ELELLLMSTENELKG HHHHHHHHCCCCCCC	32.32	29083192
305	Phosphorylation	LELLLMSTENELKGQ HHHHHHHCCCCCCCC	28.94	30576142
333	Phosphorylation	GWHSTTIADHTRPHG CCEECEECCCCCCCC	10.63	-
363	Phosphorylation	SLPADPGSLPEESAS CCCCCCCCCCHHHCC	46.25	26074081
368	Phosphorylation	PGSLPEESASPARCM CCCCCHHHCCCCEEE	32.17	26074081
370	Phosphorylation	SLPEESASPARCMIV CCCHHHCCCCEEEEE	28.50	26074081
381	Phosphorylation	CMIVHQGTILDNVKN EEEEECCCHHHHHHH	16.28	26074081
386	Acetylation	QGTILDNVKNLLEFA CCCHHHHHHHHHHHH	4.31	19608861
386	Ubiquitination	QGTILDNVKNLLEFA CCCHHHHHHHHHHHH	4.31	19608861
395	Acetylation	NLLEFAETLQFIDSF HHHHHHHHHHHHHHH	23.56	19608861
395	Ubiquitination	NLLEFAETLQFIDSF HHHHHHHHHHHHHHH	23.56	19608861
400	Acetylation	AETLQFIDSFLNTSS HHHHHHHHHHHCCCC	34.33	10656693
405	Phosphorylation	FIDSFLNTSSNHENS HHHHHHCCCCCCCCC	35.36	26074081
406	Phosphorylation	IDSFLNTSSNHENSD HHHHHCCCCCCCCCC	28.24	26074081
407	Phosphorylation	DSFLNTSSNHENSDL HHHHCCCCCCCCCCC	39.92	26074081
418	Phosphorylation	NSDLEMPSLTSTPLI CCCCCCCCCCCCCCC	42.86	-
420	Phosphorylation	DLEMPSLTSTPLIGH CCCCCCCCCCCCCCC	34.59	-
432	Phosphorylation	IGHKLTVTTPFHRDQ CCCEEEEECCCCCCC	24.42	27251275
433	Phosphorylation	GHKLTVTTPFHRDQT CCEEEEECCCCCCCC	21.44	27251275
436	Acetylation	LTVTTPFHRDQTVKT EEEECCCCCCCCCCC	33.34	19608861
436	Ubiquitination	LTVTTPFHRDQTVKT EEEECCCCCCCCCCC	33.34	19608861
442	Ubiquitination	FHRDQTVKTQKENTV CCCCCCCCCCCCCCE	48.93	-
445	Acetylation	DQTVKTQKENTVFRT CCCCCCCCCCCEECC	59.15	23749302
445	Ubiquitination	DQTVKTQKENTVFRT CCCCCCCCCCCEECC	59.15	19608861
448	Phosphorylation	VKTQKENTVFRTPAI CCCCCCCCEECCHHH	23.32	24719451
450	Acetylation	TQKENTVFRTPAIKR CCCCCCEECCHHHHH	7.29	10656693
452	Phosphorylation	KENTVFRTPAIKRSI CCCCEECCHHHHHHH	12.95	28348404
457	Methylation	FRTPAIKRSILESSP ECCHHHHHHHHHCCC	23.86	115384183
457 (in isoform 8)	Phosphorylation	-	23.86	22210691
458	Phosphorylation	RTPAIKRSILESSPR CCHHHHHHHHHCCCC	26.90	28111955
458 (in isoform 8)	Phosphorylation	-	26.90	22210691
462	Phosphorylation	IKRSILESSPRTPTP HHHHHHHCCCCCCCC	42.04	26074081
463	Phosphorylation	KRSILESSPRTPTPF HHHHHHCCCCCCCCC	14.71	26074081
465	Methylation	SILESSPRTPTPFKH HHHHCCCCCCCCCHH	56.11	115384193
466	Phosphorylation	ILESSPRTPTPFKHA HHHCCCCCCCCCHHH	34.59	26074081
468	Phosphorylation	ESSPRTPTPFKHALA HCCCCCCCCCHHHHH	40.52	26074081
468	Acetylation	ESSPRTPTPFKHALA HCCCCCCCCCHHHHH	40.52	19608861
468	Ubiquitination	ESSPRTPTPFKHALA HCCCCCCCCCHHHHH	40.52	19608861
470 (in isoform 7)	Phosphorylation	-	11.30	22210691
471	Methylation	PRTPTPFKHALAAQE CCCCCCCHHHHHHCC	29.22	60111
471	Acetylation	PRTPTPFKHALAAQE CCCCCCCHHHHHHCC	29.22	19608861
471	Ubiquitination	PRTPTPFKHALAAQE CCCCCCCHHHHHHCC	29.22	19608861
471 (in isoform 7)	Phosphorylation	-	29.22	22210691
473 (in isoform 4)	Phosphorylation	-	10.25	22210691
474 (in isoform 4)	Phosphorylation	-	3.98	22210691
477	Acetylation	FKHALAAQEIKYGPL CHHHHHHCCCCCCCC	47.54	19608861
477	Ubiquitination	FKHALAAQEIKYGPL CHHHHHHCCCCCCCC	47.54	19608861
480	Acetylation	ALAAQEIKYGPLKML HHHHCCCCCCCCCCC	43.32	19608861
480	Sumoylation	ALAAQEIKYGPLKML HHHHCCCCCCCCCCC	43.32	-
480	Ubiquitination	ALAAQEIKYGPLKML HHHHCCCCCCCCCCC	43.32	19608861
480	Sumoylation	ALAAQEIKYGPLKML HHHHCCCCCCCCCCC	43.32	28112733
482	Acetylation	AAQEIKYGPLKMLPQ HHCCCCCCCCCCCCC	18.96	10656693
485	Acetylation	EIKYGPLKMLPQTPS CCCCCCCCCCCCCHH	41.34	10656693
485	Ubiquitination	EIKYGPLKMLPQTPS CCCCCCCCCCCCCHH	41.34	-
490	Phosphorylation	PLKMLPQTPSHLVED CCCCCCCCHHHHHHH	25.48	28634298
492	Phosphorylation	KMLPQTPSHLVEDLQ CCCCCCHHHHHHHHH	32.61	28634298
503	Sumoylation	EDLQDVIKQESDESG HHHHHHHHHHCCCCC	48.11	-
503	Sumoylation	EDLQDVIKQESDESG HHHHHHHHHHCCCCC	48.11	-
527	Sumoylation	PPLLKKIKQEVESPT CHHHHHHHHHHCCCC	49.65	-
527	Sumoylation	PPLLKKIKQEVESPT CHHHHHHHHHHCCCC	49.65	-
532	Phosphorylation	KIKQEVESPTDKSGN HHHHHHCCCCCCCCC	37.97	23401153
534	Phosphorylation	KQEVESPTDKSGNFF HHHHCCCCCCCCCEE	66.40	2202948
553 (in isoform 4)	Phosphorylation	-	31.76	27251275
557	Phosphorylation	SLNTQLFTQTSPVAD CCCCEEEEECCCCCC	39.26	26074081
559	Phosphorylation	NTQLFTQTSPVADAP CCEEEEECCCCCCCC	31.75	26074081
560	Phosphorylation	TQLFTQTSPVADAPN CEEEEECCCCCCCCC	13.94	26074081
563 (in isoform 4)	Ubiquitination	-	15.61	-
566 (in isoform 4)	Ubiquitination	-	29.01	-
573 (in isoform 4)	Phosphorylation	-	4.19	27251275
576	Acetylation	LTSSVLMAPASEDED CCCCEEECCCCCCCC	7.73	19608861
576	Ubiquitination	LTSSVLMAPASEDED CCCCEEECCCCCCCC	7.73	19608861
584 (in isoform 4)	Phosphorylation	-	38.69	27251275
585	Acetylation	ASEDEDNVLKAFTVP CCCCCCCCCHHEECC	10.05	19608861
585	Ubiquitination	ASEDEDNVLKAFTVP CCCCCCCCCHHEECC	10.05	19608861
587 (in isoform 4)	Phosphorylation	-	36.85	24719451
589	Acetylation	EDNVLKAFTVPKNRS CCCCCHHEECCCCCC	7.27	19608861
589	Ubiquitination	EDNVLKAFTVPKNRS CCCCCHHEECCCCCC	7.27	19608861
590	Acetylation	DNVLKAFTVPKNRSL CCCCHHEECCCCCCC	40.53	10656693
592 (in isoform 4)	Ubiquitination	-	25.75	-
592	Acetylation	VLKAFTVPKNRSLAS CCHHEECCCCCCCCC	25.75	19608861
592	Ubiquitination	VLKAFTVPKNRSLAS CCHHEECCCCCCCCC	25.75	19608861
593	Ubiquitination	LKAFTVPKNRSLASP CHHEECCCCCCCCCC	61.73	-
596	Phosphorylation	FTVPKNRSLASPLQP EECCCCCCCCCCCCC	37.37	28464451
598	Acetylation	VPKNRSLASPLQPCS CCCCCCCCCCCCCCC	15.45	19608861
598	Ubiquitination	VPKNRSLASPLQPCS CCCCCCCCCCCCCCC	15.45	19608861
599	Phosphorylation	PKNRSLASPLQPCSS CCCCCCCCCCCCCCC	31.28	23401153
601 (in isoform 4)	Ubiquitination	-	9.10	-
601	Acetylation	NRSLASPLQPCSSTW CCCCCCCCCCCCCCC	9.10	19608861
601	Ubiquitination	NRSLASPLQPCSSTW CCCCCCCCCCCCCCC	9.10	19608861
603	Acetylation	SLASPLQPCSSTWEP CCCCCCCCCCCCCCC	27.86	10656693
605	Phosphorylation	ASPLQPCSSTWEPAS CCCCCCCCCCCCCCC	37.17	26552605
606	Phosphorylation	SPLQPCSSTWEPASC CCCCCCCCCCCCCCC	44.23	26552605
606	Acetylation	SPLQPCSSTWEPASC CCCCCCCCCCCCCCC	44.23	10656693
607	Phosphorylation	PLQPCSSTWEPASCG CCCCCCCCCCCCCCC	19.97	26552605
612	Phosphorylation	SSTWEPASCGKMEEQ CCCCCCCCCCCCHHH	33.83	26552605
615	Ubiquitination	WEPASCGKMEEQMTS CCCCCCCCCHHHHCC	47.68	-
615	Acetylation	WEPASCGKMEEQMTS CCCCCCCCCHHHHCC	47.68	25953088
621	Phosphorylation	GKMEEQMTSSSQARK CCCHHHHCCHHHHHH	25.75	-
624	Phosphorylation	EEQMTSSSQARKYVN HHHHCCHHHHHHHHH	27.85	-
628	Ubiquitination	TSSSQARKYVNAFSA CCHHHHHHHHHHHHH	57.47	-
653 (in isoform 4)	Phosphorylation	-		24719451
680 (in isoform 4)	Phosphorylation	-		27251275
714 (in isoform 4)	Ubiquitination	-		-
720 (in isoform 4)	Phosphorylation	-		24719451
736 (in isoform 4)	Ubiquitination	-		-
749 (in isoform 4)	Ubiquitination	-		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
11	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
11	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
11	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
12	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
12	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
12	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
532	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
532	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
532	S	Phosphorylation	Kinase	MAPK_GROUP	-	PhosphoELM
-	K	Ubiquitination	E3 ubiquitin ligase	FBXW7	Q969H0	PMID:18765672
-	K	Ubiquitination	E3 ubiquitin ligase	SIAH1	Q8IUQ4	PMID:10747903

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CBP_HUMAN	CREBBP	genetic	11423988
NUCL_HUMAN	NCL	physical	10660576
CEBPB_HUMAN	CEBPB	physical	11792321
CEBPE_HUMAN	CEBPE	physical	10233885
MAF_HUMAN	MAF	physical	9566892
SND1_HUMAN	SND1	physical	8756344
PAX5_HUMAN	PAX5	physical	11781241
FBXW7_HUMAN	FBXW7	physical	18765672
ZMY11_HUMAN	ZMYND11	physical	11244510
KMT2A_HUMAN	KMT2A	physical	20093773
WDR5_HUMAN	WDR5	physical	20093773
RBBP5_HUMAN	RBBP5	physical	20093773
ASH2L_HUMAN	ASH2L	physical	20093773
MEN1_HUMAN	MEN1	physical	20093773
SP100_HUMAN	SP100	physical	20211142
PARP1_HUMAN	PARP1	physical	18945670
HIPK2_HUMAN	HIPK2	physical	15082531
EP300_HUMAN	EP300	physical	11585920
TIF1B_HUMAN	TRIM28	physical	14761981
SKI_HUMAN	SKI	physical	14761981
SIN3A_HUMAN	SIN3A	physical	14761981
NCOR1_HUMAN	NCOR1	physical	14761981
UBC9_HUMAN	UBE2I	physical	11779867
CHD3_HUMAN	CHD3	physical	17344210
EP300_HUMAN	EP300	physical	20364308
KAT2B_HUMAN	KAT2B	physical	20364308
FBXW7_MOUSE	Fbxw7	physical	19421138
KAT5_HUMAN	KAT5	physical	22110127
TRAF6_HUMAN	TRAF6	physical	18093978
FBXW5_HUMAN	FBXW5	physical	22910413
DDB1_HUMAN	DDB1	physical	22910413
CUL4A_HUMAN	CUL4A	physical	22910413
PIAS1_HUMAN	PIAS1	physical	21338522
MYOZ2_HUMAN	MYOZ2	physical	21988832
PPM1K_HUMAN	PPM1K	physical	21988832
ERC2_HUMAN	ERC2	physical	20195357
RENT2_HUMAN	UPF2	physical	20195357
FBXW7_HUMAN	FBXW7	physical	21092141
PIAS1_HUMAN	PIAS1	physical	27032383

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-471 AND LYS-480, AND MASSSPECTROMETRY.
PubMed: 19608861