MAF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAF_HUMAN
• UniProt AC: O75444
• Protein Name: Transcription factor Maf
• Gene Name: MAF
• Organism: Homo sapiens (Human).
• Sequence Length: 373
• Subcellular Localization: Nucleus .
• Protein Description: Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters..
• Protein Sequence: MASELAMSNSDLPTSPLAMEYVNDFDLMKFEVKKEPVETDRIISQCGRLIAGGSLSSTPMSTPCSSVPPSPSFSAPSPGSGSEQKAHLEDYYWMTGYPQQLNPEALGFSPEDAVEALISNSHQLQGGFDGYARGAQQLAAAAGAGAGASLGGSGEEMGPAAAVVSAVIAAAAAQSGAGPHYHHHHHHAAGHHHHPTAGAPGAAGSAAASAGGAGGAGGGGPASAGGGGGGGGGGGGGGAAGAGGALHPHHAAGGLHFDDRFSDEQLVTMSVRELNRQLRGVSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHVLESEKNQLLQQVDHLKQEISRLVRERDAYKEKYEKLVSSGFRENGSSSDNPSSPEFFM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MASELAMSNSDLPTS CCHHHHCCCCCCCCC	27.81	28348404
10	Phosphorylation	SELAMSNSDLPTSPL HHHHCCCCCCCCCHH	32.97	28348404
14	Phosphorylation	MSNSDLPTSPLAMEY CCCCCCCCCHHHHHH	50.72	28348404
15	Phosphorylation	SNSDLPTSPLAMEYV CCCCCCCCHHHHHHC	18.90	27251275
21	Phosphorylation	TSPLAMEYVNDFDLM CCHHHHHHCCHHHCC	7.46	-
29	Sumoylation	VNDFDLMKFEVKKEP CCHHHCCCEEECCCC	45.75	28112733
33	Sumoylation	DLMKFEVKKEPVETD HCCCEEECCCCCCHH	44.19	28112733
70	Phosphorylation	PCSSVPPSPSFSAPS CCCCCCCCCCCCCCC	27.40	-
85	Ubiquitination	PGSGSEQKAHLEDYY CCCCCHHHHHHHHHH	33.45	-
92	Phosphorylation	KAHLEDYYWMTGYPQ HHHHHHHHHHCCCCC	10.88	-
131	Phosphorylation	LQGGFDGYARGAQQL HCCCCCHHHHHHHHH	8.58	-
297	Ubiquitination	KQKRRTLKNRGYAQS HHHHHHHHHCCHHHH	43.94	-
301	Phosphorylation	RTLKNRGYAQSCRFK HHHHHCCHHHHHHHH	9.76	22817900
331	Sumoylation	LQQVDHLKQEISRLV HHHHHHHHHHHHHHH	42.33	28112733
348	Phosphorylation	RDAYKEKYEKLVSSG HHHHHHHHHHHHHCC	21.27	-
350	Ubiquitination	AYKEKYEKLVSSGFR HHHHHHHHHHHCCCC	51.61	-
353	Phosphorylation	EKYEKLVSSGFRENG HHHHHHHHCCCCCCC	34.87	30576142
361	Phosphorylation	SGFRENGSSSDNPSS CCCCCCCCCCCCCCC	37.95	30576142
362	Phosphorylation	GFRENGSSSDNPSSP CCCCCCCCCCCCCCC	43.01	30576142
368	Phosphorylation	SSSDNPSSPEFFM-- CCCCCCCCCCCCC--	29.70	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAF_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAF_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EP300_HUMAN	EP300	physical	11943779
CBP_HUMAN	CREBBP	physical	11943779
USF2_HUMAN	USF2	physical	9070273
SOX9_HUMAN	SOX9	physical	12381733
MAFG_HUMAN	MAFG	physical	12149651
MAF_HUMAN	MAF	physical	12149651
HXD12_HUMAN	HOXD12	physical	11036080
SMCA5_HUMAN	SMARCA5	physical	16675956
HDAC2_HUMAN	HDAC2	physical	17287852
SIN3A_HUMAN	SIN3A	physical	17287852
UBC9_HUMAN	UBE2I	physical	19553542
PML_HUMAN	PML	physical	19553542
MAFB_HUMAN	MAFB	physical	23661758
MAF_HUMAN	MAF	physical	23661758
ATF4_HUMAN	ATF4	physical	23661758
FOSL1_HUMAN	FOSL1	physical	23661758
FOS_HUMAN	FOS	physical	23661758
NF2L2_HUMAN	NFE2L2	physical	26078718

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.