MAF_HUMAN - dbPTM
MAF_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MAF_HUMAN
UniProt AC O75444
Protein Name Transcription factor Maf
Gene Name MAF
Organism Homo sapiens (Human).
Sequence Length 373
Subcellular Localization Nucleus .
Protein Description Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters..
Protein Sequence MASELAMSNSDLPTSPLAMEYVNDFDLMKFEVKKEPVETDRIISQCGRLIAGGSLSSTPMSTPCSSVPPSPSFSAPSPGSGSEQKAHLEDYYWMTGYPQQLNPEALGFSPEDAVEALISNSHQLQGGFDGYARGAQQLAAAAGAGAGASLGGSGEEMGPAAAVVSAVIAAAAAQSGAGPHYHHHHHHAAGHHHHPTAGAPGAAGSAAASAGGAGGAGGGGPASAGGGGGGGGGGGGGGAAGAGGALHPHHAAGGLHFDDRFSDEQLVTMSVRELNRQLRGVSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHVLESEKNQLLQQVDHLKQEISRLVRERDAYKEKYEKLVSSGFRENGSSSDNPSSPEFFM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMASELAMSNSDLPTS
CCHHHHCCCCCCCCC
27.8128348404
10PhosphorylationSELAMSNSDLPTSPL
HHHHCCCCCCCCCHH
32.9728348404
14PhosphorylationMSNSDLPTSPLAMEY
CCCCCCCCCHHHHHH
50.7228348404
15PhosphorylationSNSDLPTSPLAMEYV
CCCCCCCCHHHHHHC
18.9027251275
21PhosphorylationTSPLAMEYVNDFDLM
CCHHHHHHCCHHHCC
7.46-
29SumoylationVNDFDLMKFEVKKEP
CCHHHCCCEEECCCC
45.7528112733
33SumoylationDLMKFEVKKEPVETD
HCCCEEECCCCCCHH
44.1928112733
70PhosphorylationPCSSVPPSPSFSAPS
CCCCCCCCCCCCCCC
27.40-
85UbiquitinationPGSGSEQKAHLEDYY
CCCCCHHHHHHHHHH
33.45-
92PhosphorylationKAHLEDYYWMTGYPQ
HHHHHHHHHHCCCCC
10.88-
131PhosphorylationLQGGFDGYARGAQQL
HCCCCCHHHHHHHHH
8.58-
297UbiquitinationKQKRRTLKNRGYAQS
HHHHHHHHHCCHHHH
43.94-
301PhosphorylationRTLKNRGYAQSCRFK
HHHHHCCHHHHHHHH
9.7622817900
331SumoylationLQQVDHLKQEISRLV
HHHHHHHHHHHHHHH
42.3328112733
348PhosphorylationRDAYKEKYEKLVSSG
HHHHHHHHHHHHHCC
21.27-
350UbiquitinationAYKEKYEKLVSSGFR
HHHHHHHHHHHCCCC
51.61-
353PhosphorylationEKYEKLVSSGFRENG
HHHHHHHHCCCCCCC
34.8730576142
361PhosphorylationSGFRENGSSSDNPSS
CCCCCCCCCCCCCCC
37.9530576142
362PhosphorylationGFRENGSSSDNPSSP
CCCCCCCCCCCCCCC
43.0130576142
368PhosphorylationSSSDNPSSPEFFM--
CCCCCCCCCCCCC--
29.7030576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MAF_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MAF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MAF_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EP300_HUMANEP300physical
11943779
CBP_HUMANCREBBPphysical
11943779
USF2_HUMANUSF2physical
9070273
SOX9_HUMANSOX9physical
12381733
MAFG_HUMANMAFGphysical
12149651
MAF_HUMANMAFphysical
12149651
HXD12_HUMANHOXD12physical
11036080
SMCA5_HUMANSMARCA5physical
16675956
HDAC2_HUMANHDAC2physical
17287852
SIN3A_HUMANSIN3Aphysical
17287852
UBC9_HUMANUBE2Iphysical
19553542
PML_HUMANPMLphysical
19553542
MAFB_HUMANMAFBphysical
23661758
MAF_HUMANMAFphysical
23661758
ATF4_HUMANATF4physical
23661758
FOSL1_HUMANFOSL1physical
23661758
FOS_HUMANFOSphysical
23661758
NF2L2_HUMANNFE2L2physical
26078718

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MAF_HUMAN

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Related Literatures of Post-Translational Modification

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