UniProt ID | MAF_HUMAN | |
---|---|---|
UniProt AC | O75444 | |
Protein Name | Transcription factor Maf | |
Gene Name | MAF | |
Organism | Homo sapiens (Human). | |
Sequence Length | 373 | |
Subcellular Localization | Nucleus . | |
Protein Description | Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters.. | |
Protein Sequence | MASELAMSNSDLPTSPLAMEYVNDFDLMKFEVKKEPVETDRIISQCGRLIAGGSLSSTPMSTPCSSVPPSPSFSAPSPGSGSEQKAHLEDYYWMTGYPQQLNPEALGFSPEDAVEALISNSHQLQGGFDGYARGAQQLAAAAGAGAGASLGGSGEEMGPAAAVVSAVIAAAAAQSGAGPHYHHHHHHAAGHHHHPTAGAPGAAGSAAASAGGAGGAGGGGPASAGGGGGGGGGGGGGGAAGAGGALHPHHAAGGLHFDDRFSDEQLVTMSVRELNRQLRGVSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHVLESEKNQLLQQVDHLKQEISRLVRERDAYKEKYEKLVSSGFRENGSSSDNPSSPEFFM | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
|
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
8 | Phosphorylation | MASELAMSNSDLPTS CCHHHHCCCCCCCCC | 27.81 | 28348404 | |
10 | Phosphorylation | SELAMSNSDLPTSPL HHHHCCCCCCCCCHH | 32.97 | 28348404 | |
14 | Phosphorylation | MSNSDLPTSPLAMEY CCCCCCCCCHHHHHH | 50.72 | 28348404 | |
15 | Phosphorylation | SNSDLPTSPLAMEYV CCCCCCCCHHHHHHC | 18.90 | 27251275 | |
21 | Phosphorylation | TSPLAMEYVNDFDLM CCHHHHHHCCHHHCC | 7.46 | - | |
29 | Sumoylation | VNDFDLMKFEVKKEP CCHHHCCCEEECCCC | 45.75 | 28112733 | |
33 | Sumoylation | DLMKFEVKKEPVETD HCCCEEECCCCCCHH | 44.19 | 28112733 | |
70 | Phosphorylation | PCSSVPPSPSFSAPS CCCCCCCCCCCCCCC | 27.40 | - | |
85 | Ubiquitination | PGSGSEQKAHLEDYY CCCCCHHHHHHHHHH | 33.45 | - | |
92 | Phosphorylation | KAHLEDYYWMTGYPQ HHHHHHHHHHCCCCC | 10.88 | - | |
131 | Phosphorylation | LQGGFDGYARGAQQL HCCCCCHHHHHHHHH | 8.58 | - | |
297 | Ubiquitination | KQKRRTLKNRGYAQS HHHHHHHHHCCHHHH | 43.94 | - | |
301 | Phosphorylation | RTLKNRGYAQSCRFK HHHHHCCHHHHHHHH | 9.76 | 22817900 | |
331 | Sumoylation | LQQVDHLKQEISRLV HHHHHHHHHHHHHHH | 42.33 | 28112733 | |
348 | Phosphorylation | RDAYKEKYEKLVSSG HHHHHHHHHHHHHCC | 21.27 | - | |
350 | Ubiquitination | AYKEKYEKLVSSGFR HHHHHHHHHHHCCCC | 51.61 | - | |
353 | Phosphorylation | EKYEKLVSSGFRENG HHHHHHHHCCCCCCC | 34.87 | 30576142 | |
361 | Phosphorylation | SGFRENGSSSDNPSS CCCCCCCCCCCCCCC | 37.95 | 30576142 | |
362 | Phosphorylation | GFRENGSSSDNPSSP CCCCCCCCCCCCCCC | 43.01 | 30576142 | |
368 | Phosphorylation | SSSDNPSSPEFFM-- CCCCCCCCCCCCC-- | 29.70 | 30576142 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MAF_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MAF_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MAF_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
EP300_HUMAN | EP300 | physical | 11943779 | |
CBP_HUMAN | CREBBP | physical | 11943779 | |
USF2_HUMAN | USF2 | physical | 9070273 | |
SOX9_HUMAN | SOX9 | physical | 12381733 | |
MAFG_HUMAN | MAFG | physical | 12149651 | |
MAF_HUMAN | MAF | physical | 12149651 | |
HXD12_HUMAN | HOXD12 | physical | 11036080 | |
SMCA5_HUMAN | SMARCA5 | physical | 16675956 | |
HDAC2_HUMAN | HDAC2 | physical | 17287852 | |
SIN3A_HUMAN | SIN3A | physical | 17287852 | |
UBC9_HUMAN | UBE2I | physical | 19553542 | |
PML_HUMAN | PML | physical | 19553542 | |
MAFB_HUMAN | MAFB | physical | 23661758 | |
MAF_HUMAN | MAF | physical | 23661758 | |
ATF4_HUMAN | ATF4 | physical | 23661758 | |
FOSL1_HUMAN | FOSL1 | physical | 23661758 | |
FOS_HUMAN | FOS | physical | 23661758 | |
NF2L2_HUMAN | NFE2L2 | physical | 26078718 |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
loading...