dbPTM

MAFB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MAFB_HUMAN
UniProt AC	Q9Y5Q3
Protein Name	Transcription factor MafB
Gene Name	MAFB
Organism	Homo sapiens (Human).
Sequence Length	323
Subcellular Localization	Nucleus .
Protein Description	Acts as a transcriptional activator or repressor. [PubMed: 27181683 Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity Involved either as an oncogene or as a tumor suppressor, depending on the cell context.]
Protein Sequence	MAAELSMGPELPTSPLAMEYVNDFDLLKFDVKKEPLGRAERPGRPCTRLQPAGSVSSTPLSTPCSSVPSSPSFSPTEQKTHLEDLYWMASNYQQMNPEALNLTPEDAVEALIGSHPVPQPLQSFDSFRGAHHHHHHHHPHPHHAYPGAGVAHDELGPHAHPHHHHHHQASPPPSSAASPAQQLPTSHPGPGPHATASATAAGGNGSVEDRFSDDQLVSMSVRELNRHLRGFTKDEVIRLKQKRRTLKNRGYAQSCRYKRVQQKHHLENEKTQLIQQVEQLKQEVSRLARERDAYKVKCEKLANSGFREAGSTSDSPSSPEFFL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	SMGPELPTSPLAMEY CCCCCCCCCCCHHHH	56.45	27732954
14	Phosphorylation	MGPELPTSPLAMEYV CCCCCCCCCCHHHHC	18.90	25849741
32	Sumoylation	DLLKFDVKKEPLGRA HCEECCCCCCCCCCC	53.95	-
47	Phosphorylation	ERPGRPCTRLQPAGS CCCCCCCCCCCCCCC	36.78	22210691
58	Phosphorylation	PAGSVSSTPLSTPCS CCCCCCCCCCCCCCC	22.27	22210691
61	Phosphorylation	SVSSTPLSTPCSSVP CCCCCCCCCCCCCCC	31.35	27251275
62	Phosphorylation	VSSTPLSTPCSSVPS CCCCCCCCCCCCCCC	35.68	27251275
65	Phosphorylation	TPLSTPCSSVPSSPS CCCCCCCCCCCCCCC	35.26	27251275
66	Phosphorylation	PLSTPCSSVPSSPSF CCCCCCCCCCCCCCC	44.77	27251275
69	Phosphorylation	TPCSSVPSSPSFSPT CCCCCCCCCCCCCCC	53.37	24719451
70	Phosphorylation	PCSSVPSSPSFSPTE CCCCCCCCCCCCCCC	20.63	28348404
72	Phosphorylation	SSVPSSPSFSPTEQK CCCCCCCCCCCCCCC	40.06	27251275
74	Phosphorylation	VPSSPSFSPTEQKTH CCCCCCCCCCCCCHH	34.94	27251275
103	Phosphorylation	NPEALNLTPEDAVEA CHHHHCCCHHHHHHH	24.45	-
251	Phosphorylation	RTLKNRGYAQSCRYK HHHHHCHHHHHHHHH	9.76	18083107
270	Ubiquitination	KHHLENEKTQLIQQV HHHHHHHHHHHHHHH	53.83	29967540
281	Ubiquitination	IQQVEQLKQEVSRLA HHHHHHHHHHHHHHH	44.07	29967540
297	Sumoylation	ERDAYKVKCEKLANS HHHHHHHHHHHHHHC	32.31	-
304	Phosphorylation	KCEKLANSGFREAGS HHHHHHHCCCCCCCC	33.43	-
311	Phosphorylation	SGFREAGSTSDSPSS CCCCCCCCCCCCCCC	31.61	27251275
312	Phosphorylation	GFREAGSTSDSPSSP CCCCCCCCCCCCCCC	35.32	23090842
313	Phosphorylation	FREAGSTSDSPSSPE CCCCCCCCCCCCCCC	37.48	23090842
315	Phosphorylation	EAGSTSDSPSSPEFF CCCCCCCCCCCCCCC	26.84	23090842
317	Phosphorylation	GSTSDSPSSPEFFL- CCCCCCCCCCCCCC-	63.58	20363803
318	Phosphorylation	STSDSPSSPEFFL-- CCCCCCCCCCCCC--	31.65	20363803

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MAFB_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
32	K	Sumoylation	-
Sumoylation on Lys-32 and Lys-297 stimulates its transcriptional repression activity and promotes macrophage differentiation from myeloid progenitors (By similarity).
297	K	Sumoylation	-
Sumoylation on Lys-32 and Lys-297 stimulates its transcriptional repression activity and promotes macrophage differentiation from myeloid progenitors (By similarity).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MAFB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MAFB_HUMAN	MAFB	physical	15107855
ZDHC2_HUMAN	ZDHHC2	physical	20211142
ZF64A_HUMAN	ZFP64	physical	20211142
ZF64B_HUMAN	ZFP64	physical	20211142
MAFB_HUMAN	MAFB	physical	16219768
MAFB_HUMAN	MAFB	physical	12196529
IRF3_HUMAN	IRF3	physical	20581830
IRF7_HUMAN	IRF7	physical	20581830
IKKE_HUMAN	IKBKE	physical	20581830
BACH1_HUMAN	BACH1	physical	23661758
MAFB_HUMAN	MAFB	physical	23661758
MAF_HUMAN	MAF	physical	23661758
ATF4_HUMAN	ATF4	physical	23661758
FOSL1_HUMAN	FOSL1	physical	23661758
FOS_HUMAN	FOS	physical	23661758
ZWINT_HUMAN	ZWINT	physical	21988832
NCOA6_HUMAN	NCOA6	physical	26180087
KDM6A_HUMAN	KDM6A	physical	26180087
RBBP5_HUMAN	RBBP5	physical	26180087
KAT2B_HUMAN	KAT2B	physical	26180087
PAX6_HUMAN	PAX6	physical	26180087
ISL1_HUMAN	ISL1	physical	26180087
MAFB_HUMAN	MAFB	physical	12514174

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
166300	Multicentric carpotarsal osteolysis syndrome (MCTO)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MAFB_HUMAN

Related Literatures of Post-Translational Modification

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