ZDHC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZDHC2_HUMAN
• UniProt AC: Q9UIJ5
• Protein Name: Palmitoyltransferase ZDHHC2
• Gene Name: ZDHHC2
• Organism: Homo sapiens (Human).
• Sequence Length: 367
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Palmitoyltransferase specific for GAP43 and DLG4/PSD95..
• Protein Sequence: MAPSGPGSSARRRCRRVLYWIPVVFITLLLGWSYYAYAIQLCIVSMENTGEQVVCLMAYHLLFAMFVWSYWKTIFTLPMNPSKEFHLSYAEKDLLEREPRGEAHQEVLRRAAKDLPIYTRTMSGAIRYCDRCQLIKPDRCHHCSVCDKCILKMDHHCPWVNNCVGFSNYKFFLLFLAYSLLYCLFIAATDLQYFIKFWTNGLPDTQAKFHIMFLFFAAAMFSVSLSSLFGYHCWLVSKNKSTLEAFRSPVFRHGTDKNGFSLGFSKNMRQVFGDEKKYWLLPIFSSLGDGCSFPTCLVNQDPEQASTPAGLNSTAKNLENHQFPAKPLRESQSHLLTDSQSWTESSINPGKCKAGMSNPALTMENET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAPSGPGSSAR ----CCCCCCCHHHH	48.35	-
8	Phosphorylation	MAPSGPGSSARRRCR CCCCCCCHHHHHHHH	24.77	-
9	Phosphorylation	APSGPGSSARRRCRR CCCCCCHHHHHHHHH	31.54	-
92	Ubiquitination	FHLSYAEKDLLEREP EEHHHHHHHHHHCCC	45.57	-
113	Ubiquitination	EVLRRAAKDLPIYTR HHHHHHHHCCCEEEE	59.83	-
119	Phosphorylation	AKDLPIYTRTMSGAI HHCCCEEEECCCCHH	22.00	-
257	Ubiquitination	VFRHGTDKNGFSLGF HHHCCCCCCCCCCCC	59.83	-
316	Ubiquitination	AGLNSTAKNLENHQF CCCCHHHHHHHHCCC	63.25	-
326	Ubiquitination	ENHQFPAKPLRESQS HHCCCCCCCCCHHHH	44.84	-
331	Phosphorylation	PAKPLRESQSHLLTD CCCCCCHHHHHCCCC	30.46	30576142
333	Phosphorylation	KPLRESQSHLLTDSQ CCCCHHHHHCCCCCC	25.94	30576142
337	Phosphorylation	ESQSHLLTDSQSWTE HHHHHCCCCCCCCCC	39.71	29514088
339	Phosphorylation	QSHLLTDSQSWTESS HHHCCCCCCCCCCCC	22.37	30576142
341	Phosphorylation	HLLTDSQSWTESSIN HCCCCCCCCCCCCCC	39.66	30576142
343	Phosphorylation	LTDSQSWTESSINPG CCCCCCCCCCCCCCC	31.10	29514088
345	Phosphorylation	DSQSWTESSINPGKC CCCCCCCCCCCCCCC	29.19	29514088
346	Phosphorylation	SQSWTESSINPGKCK CCCCCCCCCCCCCCC	21.83	29514088
351	Ubiquitination	ESSINPGKCKAGMSN CCCCCCCCCCCCCCC	33.54	-
357	Phosphorylation	GKCKAGMSNPALTME CCCCCCCCCCCCCCC	38.45	23917254
362	Phosphorylation	GMSNPALTMENET-- CCCCCCCCCCCCC--	25.25	23186163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZDHC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZDHC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZDHC2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZDHC2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.