HXD10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXD10_HUMAN
• UniProt AC: P28358
• Protein Name: Homeobox protein Hox-D10
• Gene Name: HOXD10
• Organism: Homo sapiens (Human).
• Sequence Length: 340
• Subcellular Localization: Nucleus.
• Protein Description: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis..
• Protein Sequence: MSFPNSSPAANTFLVDSLISACRSDSFYSSSASMYMPPPSADMGTYGMQTCGLLPSLAKREVNHQNMGMNVHPYIPQVDSWTDPNRSCRIEQPVTQQVPTCSFTTNIKEESNCCMYSDKRNKLISAEVPSYQRLVPESCPVENPEVPVPGYFRLSQTYATGKTQEYNNSPEGSSTVMLQLNPRGAAKPQLSAAQLQMEKKMNEPVSGQEPTKVSQVESPEAKGGLPEERSCLAEVSVSSPEVQEKESKEEIKSDTPTSNWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEISKSVNLTDRQVKIWFQNRRMKLKKMSRENRIRELTANLTFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	RSDSFYSSSASMYMP CCCCCCCCCCCCCCC	20.67	30576142
50	Phosphorylation	MGTYGMQTCGLLPSL CCCCHHHHHCCHHHH	10.31	30576142
59	Acetylation	GLLPSLAKREVNHQN CCHHHHHHHHHCCCC	55.15	30589335
87	Phosphorylation	SWTDPNRSCRIEQPV CCCCCCCCCCCCCCC	17.87	24275569
95	Phosphorylation	CRIEQPVTQQVPTCS CCCCCCCCCCCCCCE	21.70	24275569
125	Phosphorylation	DKRNKLISAEVPSYQ CCCCEEEEEECCCHH	28.90	29978859
130	Phosphorylation	LISAEVPSYQRLVPE EEEEECCCHHHCCCC	38.79	29978859
131	Phosphorylation	ISAEVPSYQRLVPES EEEECCCHHHCCCCC	7.50	29978859
155	Phosphorylation	VPGYFRLSQTYATGK CCCEEEEEEEEECCC	19.07	22210691
158	Phosphorylation	YFRLSQTYATGKTQE EEEEEEEEECCCCEE	8.43	22210691
175	Phosphorylation	NSPEGSSTVMLQLNP CCCCCCCEEEEEECC	16.19	22210691
206	Phosphorylation	KKMNEPVSGQEPTKV HHHCCCCCCCCCCEE	45.53	30206219
211	Phosphorylation	PVSGQEPTKVSQVES CCCCCCCCEEECCCC	43.24	30206219
218	Phosphorylation	TKVSQVESPEAKGGL CEEECCCCCCCCCCC	29.23	27732954
236	Phosphorylation	RSCLAEVSVSSPEVQ HHHEEEEECCCHHHH	14.05	27732954
238	Phosphorylation	CLAEVSVSSPEVQEK HEEEEECCCHHHHHH	32.44	28857561
239	Phosphorylation	LAEVSVSSPEVQEKE EEEEECCCHHHHHHH	23.95	28857561
255	Phosphorylation	KEEIKSDTPTSNWLT HHHHHCCCCCCCCEE	35.24	28857561
269	Ubiquitination	TAKSGRKKRCPYTKH ECCCCCCCCCCCCCC	58.85	-
273	Phosphorylation	GRKKRCPYTKHQTLE CCCCCCCCCCCCCHH	31.85	12145285
275	Ubiquitination	KKRCPYTKHQTLELE CCCCCCCCCCCHHHH	28.07	-
278	Phosphorylation	CPYTKHQTLELEKEF CCCCCCCCHHHHHHH	23.17	-
290	Phosphorylation	KEFLFNMYLTRERRL HHHHHHHHHHHHHHH	13.16	12145285

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HXD10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXD10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXD10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPB4_HUMAN	SERPINB4	physical	26186194
S10A7_HUMAN	S100A7	physical	26186194
SPB4_HUMAN	SERPINB4	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.