KLF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLF2_HUMAN
• UniProt AC: Q9Y5W3
• Protein Name: Krueppel-like factor 2
• Gene Name: KLF2
• Organism: Homo sapiens (Human).
• Sequence Length: 355
• Subcellular Localization: Nucleus.
• Protein Description: Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription..
• Protein Sequence: MALSEPILPSFSTFASPCRERGLQERWPRAEPESGGTDDDLNSVLDFILSMGLDGLGAEAAPEPPPPPPPPAFYYPEPGAPPPYSAPAGGLVSELLRPELDAPLGPALHGRFLLAPPGRLVKAEPPEADGGGGYGCAPGLTRGPRGLKREGAPGPAASCMRGPGGRPPPPPDTPPLSPDGPARLPAPGPRASFPPPFGGPGFGAPGPGLHYAPPAPPAFGLFDDAAAAAAALGLAPPAARGLLTPPASPLELLEAKPKRGRRSWPRKRTATHTCSYAGCGKTYTKSSHLKAHLRTHTGEKPYHCNWDGCGWKFARSDELTRHYRKHTGHRPFQCHLCDRAFSRSDHLALHMKRHM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	LSEPILPSFSTFASP CCCCCCCCCCCCCHH	28.52	22199227
12	Phosphorylation	EPILPSFSTFASPCR CCCCCCCCCCCHHHH	27.27	22199227
13	Phosphorylation	PILPSFSTFASPCRE CCCCCCCCCCHHHHH	22.62	24719451
16	Phosphorylation	PSFSTFASPCRERGL CCCCCCCHHHHHCCH	21.97	22199227
122	Sumoylation	APPGRLVKAEPPEAD CCCCCEEECCCCCCC	52.18	-
122	Sumoylation	APPGRLVKAEPPEAD CCCCCEEECCCCCCC	52.18	-
148	Sumoylation	TRGPRGLKREGAPGP CCCCCCCCCCCCCCC	51.75	-
148	Sumoylation	TRGPRGLKREGAPGP CCCCCCCCCCCCCCC	51.75	-
173	Phosphorylation	RPPPPPDTPPLSPDG CCCCCCCCCCCCCCC	32.36	23401153
177	Phosphorylation	PPDTPPLSPDGPARL CCCCCCCCCCCCCCC	27.07	23401153
244	Phosphorylation	PAARGLLTPPASPLE HHHHCCCCCCCCHHH	32.06	22617229
248	Phosphorylation	GLLTPPASPLELLEA CCCCCCCCHHHHHHC	35.47	22617229
263	Phosphorylation	KPKRGRRSWPRKRTA CCCCCCCCCCCCCCC	39.82	24719451
282	Phosphorylation	SYAGCGKTYTKSSHL CCCCCCCCEECCHHH	23.00	26074081
283	Phosphorylation	YAGCGKTYTKSSHLK CCCCCCCEECCHHHH	18.69	26074081
284	Phosphorylation	AGCGKTYTKSSHLKA CCCCCCEECCHHHHH	29.67	26074081
286	Phosphorylation	CGKTYTKSSHLKAHL CCCCEECCHHHHHHH	18.39	20166139
287	Phosphorylation	GKTYTKSSHLKAHLR CCCEECCHHHHHHHH	34.10	20166139
290	Ubiquitination	YTKSSHLKAHLRTHT EECCHHHHHHHHHCC	28.47	-
290	Sumoylation	YTKSSHLKAHLRTHT EECCHHHHHHHHHCC	28.47	-
290	Sumoylation	YTKSSHLKAHLRTHT EECCHHHHHHHHHCC	28.47	-
295	Phosphorylation	HLKAHLRTHTGEKPY HHHHHHHHCCCCCCC	30.10	26074081
297	Phosphorylation	KAHLRTHTGEKPYHC HHHHHHCCCCCCCCC	46.56	26074081
327	Phosphorylation	TRHYRKHTGHRPFQC HHHHHHHHCCCCEEC	37.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	FBXW7	Q969H0	PMID:23507969
-	K	Ubiquitination	E3 ubiquitin ligase	WWP1	Q9H0M0	PMID:15003522
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:21382345

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLF2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLF2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WWP1_HUMAN	WWP1	physical	11375995
WWP1_HUMAN	WWP1	physical	15003522
SMUF1_HUMAN	SMURF1	physical	21382345
KAT2B_HUMAN	KAT2B	physical	16617118
PSME3_HUMAN	PSME3	physical	26776519

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.