HNF1A_HUMAN - dbPTM
HNF1A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HNF1A_HUMAN
UniProt AC P20823
Protein Name Hepatocyte nuclear factor 1-alpha
Gene Name HNF1A
Organism Homo sapiens (Human).
Sequence Length 631
Subcellular Localization Nucleus .
Protein Description Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'..
Protein Sequence MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLLAGEGPLDKGESCGGGRGELAELPNGLGETRGSEDETDDDGEDFTPPILKELENLSPEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHAGQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYSGPPPGPGPGPALPAHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGGPLVTVSTPLHQVSPTGLEPSHSLLSTEAKLVSAAGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVTQSPFMATMAQLQSPHALYSHKPEVAQYTHTGLLPQTMLITDTTNLSALASLTPTKQVFTSDTEASSESGLHTPASQATTLHVPSQDPAGIQHLQPAHRLSASPTVSSSSLVLYQSSDSSNGQSHLLPSNHSVIETFISTQMASSSQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
67PhosphorylationLPNGLGETRGSEDET
CCCCCCCCCCCCCCC		38.2326657352
70PhosphorylationGLGETRGSEDETDDD
CCCCCCCCCCCCCCC		38.2928857561
74PhosphorylationTRGSEDETDDDGEDF
CCCCCCCCCCCCCCC		57.9829116813
82PhosphorylationDDDGEDFTPPILKEL
CCCCCCCCHHHHHHH		40.2429802988
93PhosphorylationLKELENLSPEEAAHQ
HHHHHCCCHHHHHHH		41.6826657352
196PhosphorylationPTGDELPTKKGRRNR
CCCCCCCCCCCCCCC		59.0022964224
225PhosphorylationYERQKNPSKEERETL
HHHHCCCCHHHHHHH		63.1929457462
247PhosphorylationECIQRGVSPSQAQGL
HHHHCCCCHHHHCCC		22.9725072903
249PhosphorylationIQRGVSPSQAQGLGS
HHCCCCHHHHCCCCC		30.5527987026
285PhosphorylationRHKLAMDTYSGPPPG
HHHCHHCCCCCCCCC		13.4023312004
286PhosphorylationHKLAMDTYSGPPPGP
HHCHHCCCCCCCCCC		13.8423312004
287PhosphorylationKLAMDTYSGPPPGPG
HCHHCCCCCCCCCCC		47.0923312004
303O-linked_GlycosylationGPALPAHSSPGLPPP
CCCCCCCCCCCCCCC		40.0929351928
303PhosphorylationGPALPAHSSPGLPPP
CCCCCCCCCCCCCCC		40.0929802988
304O-linked_GlycosylationPALPAHSSPGLPPPA
CCCCCCCCCCCCCCC		17.0829351928
304PhosphorylationPALPAHSSPGLPPPA
CCCCCCCCCCCCCCC		17.0829802988
313PhosphorylationGLPPPALSPSKVHGV
CCCCCCCCHHHCCCE		29.2724719451
315PhosphorylationPPPALSPSKVHGVRY
CCCCCCHHHCCCEEC		43.8923312004
352O-linked_GlycosylationSTPLHQVSPTGLEPS
ECCCHHCCCCCCCCC		15.3529351928
471O-linked_GlycosylationFSQPLHPSYQQPLMP
CCCCCCCCCCCCCCC		25.4829351928
492O-linked_GlycosylationTQSPFMATMAQLQSP
CCCCHHHHHHHHCCC		10.9729351928
537PhosphorylationLSALASLTPTKQVFT
HHHHHHCCCCCEEEC		26.8124719451
560O-linked_GlycosylationSGLHTPASQATTLHV
CCCCCCHHHCEEEEC		22.8829351928
563O-linked_GlycosylationHTPASQATTLHVPSQ
CCCHHHCEEEECCCC		23.4229351928
564O-linked_GlycosylationTPASQATTLHVPSQD
CCHHHCEEEECCCCC		20.2029351928
569O-linked_GlycosylationATTLHVPSQDPAGIQ
CEEEECCCCCCCCCC		46.2429351928
587O-linked_GlycosylationPAHRLSASPTVSSSS
CCCCCCCCCCCCCCC		20.0929351928
589O-linked_GlycosylationHRLSASPTVSSSSLV
CCCCCCCCCCCCCEE		30.4429351928
591O-linked_GlycosylationLSASPTVSSSSLVLY
CCCCCCCCCCCEEEE		27.2929351928
623O-linked_GlycosylationSVIETFISTQMASSS
HHHHHHHHHHHHHCC		14.3829351928
624O-linked_GlycosylationVIETFISTQMASSSQ
HHHHHHHHHHHHCCC		19.9729351928
628O-linked_GlycosylationFISTQMASSSQ----
HHHHHHHHCCC----		25.7729351928
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
249SPhosphorylationKinaseATMQ13315
PSP
249SPhosphorylationKinaseDYR1BQ9Y463
PhosphoELM
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HNF1A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HNF1A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PHS_HUMANPCBD1physical
17353931
PHS2_HUMANPCBD2physical
17353931
RU2A_HUMANSNRPA1physical
17353931
RHPN2_HUMANRHPN2physical
17353931
CBP_HUMANCREBBPphysical
10777539
KAT2B_HUMANKAT2Bphysical
10777539
HNF1B_HUMANHNF1Bphysical
2044952
HNF1A_HUMANHNF1Aphysical
2044952
FOS_HUMANFOSphysical
11134330
STAT3_HUMANSTAT3physical
11134330
PHS_HUMANPCBD1physical
9092652
CBP_HUMANCREBBPphysical
15598887
EP300_HUMANEP300physical
15598887
SIR1_HUMANSIRT1physical
21176092
PHS_HUMANPCBD1physical
21047120
ACTB_HUMANACTBphysical
18160415
ANXA2_HUMANANXA2physical
18160415
CBX3_HUMANCBX3physical
18160415
H2A2B_HUMANHIST2H2ABphysical
18160415
HMGB1_HUMANHMGB1physical
18160415
IBP7_HUMANIGFBP7physical
18160415
LDHA_HUMANLDHAphysical
18160415
PEBP1_HUMANPEBP1physical
18160415
RANG_HUMANRANBP1physical
18160415
SRSF7_HUMANSRSF7physical
18160415
SNX14_HUMANSNX14physical
18160415
TERA_HUMANVCPphysical
18160415
VIME_HUMANVIMphysical
18160415
1433B_HUMANYWHABphysical
18160415
1433E_HUMANYWHAEphysical
18160415
1433G_HUMANYWHAGphysical
18160415
1433Z_HUMANYWHAZphysical
18160415
HNF1A_HUMANHNF1Aphysical
18160415
PHS_HUMANPCBD1physical
21988832
RYR3_HUMANRYR3physical
20195357
RNF14_HUMANRNF14physical
23449499
NCOA1_HUMANNCOA1physical
10777539
NCOA3_HUMANNCOA3physical
10777539
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
142330Hepatic adenomas familial (HEPAF)
600496Maturity-onset diabetes of the young 3 (MODY3)
612520Diabetes mellitus, insulin-dependent, 20 (IDDM20)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HNF1A_HUMAN

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