IBP7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IBP7_HUMAN
• UniProt AC: Q16270
• Protein Name: Insulin-like growth factor-binding protein 7
• Gene Name: IGFBP7
• Organism: Homo sapiens (Human).
• Sequence Length: 282
• Subcellular Localization: Secreted.
• Protein Description: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion..
• Protein Sequence: MERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCAPGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAQVYLSCEVIGIPTPVLIWNKVKRGHYGVQRTELLPGDRDNLAIQTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASASAKITVVDALHEIPVKKGEGAEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	O-linked_Glycosylation	SSSSSSDTCGPCEPA CCCCCCCCCCCCCCC	22.70	OGP
39	O-linked_Glycosylation	CGPCEPASCPPLPPL CCCCCCCCCCCCCCC	37.56	OGP
114	Ubiquitination	VSGVCVCKSRYPVCG CCCEEEECCCCCCCC	19.99	29967540
117	Phosphorylation	VCVCKSRYPVCGSDG EEEECCCCCCCCCCC	13.70	-
122	Phosphorylation	SRYPVCGSDGTTYPS CCCCCCCCCCCCCCC	27.95	-
137	Phosphorylation	GCQLRAASQRAESRG HHHHHHHHHHHHHHH	21.15	-
142	Phosphorylation	AASQRAESRGEKAIT HHHHHHHHHHCHHEE	44.60	-
146	Ubiquitination	RAESRGEKAITQVSK HHHHHHCHHEEECCC	48.16	29967540
149	Phosphorylation	SRGEKAITQVSKGTC HHHCHHEEECCCCCC	27.98	28060719
153	Ubiquitination	KAITQVSKGTCEQGP HHEEECCCCCCCCCC	60.42	29967540
171	N-linked_Glycosylation	TPPKDIWNVTGAQVY CCCHHHCCCCCCEEE	23.08	8939990
188	O-linked_Glycosylation	CEVIGIPTPVLIWNK EEEECCCCCEEECCC	24.90	OGP
201	Phosphorylation	NKVKRGHYGVQRTEL CCCCCCCCCEECCEE	23.09	-
206	O-linked_Glycosylation	GHYGVQRTELLPGDR CCCCEECCEECCCCC	17.56	55831157
206	Phosphorylation	GHYGVQRTELLPGDR CCCCEECCEECCCCC	17.56	-
220	O-linked_Glycosylation	RDNLAIQTRGGPEKH CCCEEEEECCCCCCC	25.76	55824677
230	O-linked_Glycosylation	GPEKHEVTGWVLVSP CCCCCEEEEEEEEEC	23.49	55824683
236	O-linked_Glycosylation	VTGWVLVSPLSKEDA EEEEEEEECCCHHHC	18.89	55826111
236	Phosphorylation	VTGWVLVSPLSKEDA EEEEEEEECCCHHHC	18.89	22199227
239	Phosphorylation	WVLVSPLSKEDAGEY EEEEECCCHHHCCCE	37.07	22199227
246	Phosphorylation	SKEDAGEYECHASNS CHHHCCCEEEECCCC	23.96	26091039
253	Phosphorylation	YECHASNSQGQASAS EEEECCCCCCCCCCC	32.94	-
264	O-linked_Glycosylation	ASASAKITVVDALHE CCCCCEEEEEEHHHC	17.48	55824287

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
239	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IBP7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IBP7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IGF1_HUMAN	IGF1	physical	8939990
IGF2_HUMAN	IGF2	physical	8939990
CHMP3_HUMAN	CHMP3	physical	11549700
VEGFA_HUMAN	VEGFA	physical	12407018
INS_HUMAN	INS	physical	9388210
RTN4_HUMAN	RTN4	physical	22939629
CTIP_HUMAN	RBBP8	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614224: Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.