| UniProt ID | INS_HUMAN | |
|---|---|---|
| UniProt AC | P01308 | |
| Protein Name | Insulin | |
| Gene Name | INS | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 110 | |
| Subcellular Localization | Secreted. | |
| Protein Description | Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.. | |
| Protein Sequence | MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 51 | O-linked_Glycosylation | GERGFFYTPKTRREA CCCCCEECCCCHHCC | 17.10 | OGP | |
| 76 | O-linked_Glycosylation | GGGPGAGSLQPLALE CCCCCCCCCCCHHHC | 24.25 | OGP | |
| 108 | Phosphorylation | SLYQLENYCN----- HHHHHHHHCC----- | 5.51 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of INS_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of INS_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of INS_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| A4_HUMAN | APP | physical | 21832049 | |
| ITF2_HUMAN | TCF4 | physical | 25416956 | |
| RGS20_HUMAN | RGS20 | physical | 25416956 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 616214 | Hyperproinsulinemia (HPRI) | |||||
| 125852 | Diabetes mellitus, insulin-dependent, 2 (IDDM2) | |||||
| 606176 | Diabetes mellitus, permanent neonatal (PNDM) | |||||
| 613370 | Maturity-onset diabetes of the young 10 (MODY10) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
