HNF1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HNF1B_HUMAN
• UniProt AC: P35680
• Protein Name: Hepatocyte nuclear factor 1-beta
• Gene Name: HNF1B
• Organism: Homo sapiens (Human).
• Sequence Length: 557
• Subcellular Localization: Nucleus.
• Protein Description: Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'..
• Protein Sequence: MVSKLTSLQQELLSALLSSGVTKEVLVQALEELLPSPNFGVKLETLPLSPGSGAEPDTKPVFHTLTNGHAKGRLSGDEGSEDGDDYDTPPILKELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREILRQFNQTVQSSGNMTDKSSQDQLLFLFPEFSQQSHGPGQSDDACSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSSNQTHSLNPLLSHGSPHHQPSSSPPNKLSGVRYSQQGNNEITSSSTISHHGNSAMVTSQSVLQQVSPASLDPGHNLLSPDGKMISVSGGGLPPVSTLTNIHSLSHHNPQQSQNLIMTPLSGVMAIAQSLNTSQAQSVPVINSVAGSLAALQPVQFSQQLHSPHQQPLMQQSPGSHMAQQPFMAAVTQLQNSHMYAHKQEPPQYSHTSRFPSAMVVTDTSSISTLTNMSSSKQCPLQAW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	ELLSALLSSGVTKEV HHHHHHHHCCCCHHH	26.37	22468782
19	Phosphorylation	LLSALLSSGVTKEVL HHHHHHHCCCCHHHH	36.93	22468782
22	Phosphorylation	ALLSSGVTKEVLVQA HHHHCCCCHHHHHHH	25.64	22468782
45	Phosphorylation	NFGVKLETLPLSPGS CCCCEEEECCCCCCC	44.08	25841592
49	Phosphorylation	KLETLPLSPGSGAEP EEEECCCCCCCCCCC	25.85	26657352
52	Phosphorylation	TLPLSPGSGAEPDTK ECCCCCCCCCCCCCC	37.91	30108239
58	Phosphorylation	GSGAEPDTKPVFHTL CCCCCCCCCCCEEEC	48.22	30108239
64	Phosphorylation	DTKPVFHTLTNGHAK CCCCCEEECCCCCCC	24.66	25841592
66	Phosphorylation	KPVFHTLTNGHAKGR CCCEEECCCCCCCCC	40.07	23836654
75	Phosphorylation	GHAKGRLSGDEGSED CCCCCCCCCCCCCCC	42.72	28355574
80	Phosphorylation	RLSGDEGSEDGDDYD CCCCCCCCCCCCCCC	30.39	28355574
86	Phosphorylation	GSEDGDDYDTPPILK CCCCCCCCCCHHHHH	26.85	26657352
88	Phosphorylation	EDGDDYDTPPILKEL CCCCCCCCHHHHHHH	25.41	30108239
169	Phosphorylation	TQKRAALYTWYVRKQ HHHHHHHHHHHHHHH	7.18	29759185
172	Phosphorylation	RAALYTWYVRKQREI HHHHHHHHHHHHHHH	5.20	29759185
257	Phosphorylation	YDRQKNPSKEEREAL HHCCCCCCHHHHHHH	63.19	29457462
279	Phosphorylation	ECLQRGVSPSKAHGL HHHHHCCCHHHHCCC	26.70	29496963
281	Phosphorylation	LQRGVSPSKAHGLGS HHHCCCHHHHCCCCC	34.66	30108239
288	Phosphorylation	SKAHGLGSNLVTEVR HHHCCCCCCHHHHHH	31.84	23312004
318	Phosphorylation	QKLAMDAYSSNQTHS HHHHHHHHCCCCCCC	14.36	23663014
319	Phosphorylation	KLAMDAYSSNQTHSL HHHHHHHCCCCCCCC	25.24	23663014
320	Phosphorylation	LAMDAYSSNQTHSLN HHHHHHCCCCCCCCC	21.93	23663014
323	Phosphorylation	DAYSSNQTHSLNPLL HHHCCCCCCCCCHHH	20.06	23663014
325	Phosphorylation	YSSNQTHSLNPLLSH HCCCCCCCCCHHHHC	32.98	23663014
331	Phosphorylation	HSLNPLLSHGSPHHQ CCCCHHHHCCCCCCC	33.22	23663014
334	Phosphorylation	NPLLSHGSPHHQPSS CHHHHCCCCCCCCCC	18.68	23663014
340	Phosphorylation	GSPHHQPSSSPPNKL CCCCCCCCCCCCCCC	36.56	23663014
340 (in isoform 3)	Phosphorylation	-	36.56	29116813
341	Phosphorylation	SPHHQPSSSPPNKLS CCCCCCCCCCCCCCC	54.25	23663014
341 (in isoform 3)	Phosphorylation	-	54.25	29116813
342	Phosphorylation	PHHQPSSSPPNKLSG CCCCCCCCCCCCCCC	49.03	23663014
342 (in isoform 3)	Phosphorylation	-	49.03	29116813
348	Phosphorylation	SSPPNKLSGVRYSQQ CCCCCCCCCCEEEEC	36.53	24719451
360 (in isoform 3)	Phosphorylation	-	5.00	19845377
363	Phosphorylation	GNNEITSSSTISHHG CCCEECCCCEECCCC	23.89	-
363 (in isoform 3)	Phosphorylation	-	23.89	19845377
538	Phosphorylation	AMVVTDTSSISTLTN CEEEECCCCCHHHHC	28.60	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HNF1B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HNF1B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HNF1B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CREB1_HUMAN	CREB1	physical	9671480
ATF1_HUMAN	ATF1	physical	9671480

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 137920: Renal cysts and diabetes syndrome (RCAD)
• 125853: Diabetes mellitus, non-insulin-dependent (NIDDM)
• 611955: Prostate cancer, hereditary, 11 (HPC11)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.