FOSB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FOSB_HUMAN
• UniProt AC: P53539
• Protein Name: Protein fosB
• Gene Name: FOSB
• Organism: Homo sapiens (Human).
• Sequence Length: 338
• Subcellular Localization: Nucleus.
• Protein Description: FosB interacts with Jun proteins enhancing their DNA binding activity..
• Protein Sequence: MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGSGGPSTSGTTSGPGPARPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAEVRDLPGSAPAKEDGFSWLLPPPPPPPLPFQTSQDAPPNLTASLFTHSEVQVLGDPFPVVNPSYTSSFVLTCPEVSAFAGAQRTSGSDQPSDPLNSPSLLAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	FQAFPGDYDSGSRCS CCCCCCCCCCCCCCC	20.23	22461510
11	Phosphorylation	AFPGDYDSGSRCSSS CCCCCCCCCCCCCCC	32.22	22461510
13	Phosphorylation	PGDYDSGSRCSSSPS CCCCCCCCCCCCCCC	33.78	22461510
27	Phosphorylation	SAESQYLSSVDSFGS CHHHHHHHCCCCCCC	24.31	16687504
64	O-linked_Glycosylation	TVTAITTSQDLQWLV EEEEEECCCCHHHHH	17.04	29351928
149	Phosphorylation	PRRPREETLTPEEEE CCCCCHHCCCHHHHH	31.04	26714015
151	Phosphorylation	RPREETLTPEEEEKR CCCHHCCCHHHHHHH	35.75	23401153
299	O-linked_Glycosylation	PFPVVNPSYTSSFVL CCCCCCCCCCCEEEE	35.52	29351928
327	Phosphorylation	TSGSDQPSDPLNSPS CCCCCCCCCCCCCCH	46.34	25002506
332	Phosphorylation	QPSDPLNSPSLLAL- CCCCCCCCCHHHCC-	24.45	25002506
334	Phosphorylation	SDPLNSPSLLAL--- CCCCCCCHHHCC---	35.52	25002506

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
27	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FOSB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FOSB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRA1_HUMAN	SRA1	physical	20398657

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.