HXD4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXD4_HUMAN
• UniProt AC: P09016
• Protein Name: Homeobox protein Hox-D4
• Gene Name: HOXD4
• Organism: Homo sapiens (Human).
• Sequence Length: 255
• Subcellular Localization: Nucleus.
• Protein Description: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis..
• Protein Sequence: MVMSSYMVNSKYVDPKFPPCEEYLQGGYLGEQGADYYGGGAQGADFQPPGLYPRPDFGEQPFGGSGPGPGSALPARGHGQEPGGPGGHYAAPGEPCPAPPAPPPAPLPGARAYSQSDPKQPPSGTALKQPAVVYPWMKKVHVNSVNPNYTGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQIKIWFQNRRMKWKKDHKLPNTKGRSSSSSSSSSCSSSVAPSQHLQPMAKDHHTDLTTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MVMSSYMVNSK ----CCCCCCCCCCC	13.60	28270605
5	Phosphorylation	---MVMSSYMVNSKY ---CCCCCCCCCCCC	10.11	28270605
6	Phosphorylation	--MVMSSYMVNSKYV --CCCCCCCCCCCCC	9.58	28270605
10	Phosphorylation	MSSYMVNSKYVDPKF CCCCCCCCCCCCCCC	17.60	28270605
12	Phosphorylation	SYMVNSKYVDPKFPP CCCCCCCCCCCCCCC	15.20	28270605
65	Phosphorylation	GEQPFGGSGPGPGSA CCCCCCCCCCCCCCC	42.04	24850871
123	Phosphorylation	SDPKQPPSGTALKQP CCCCCCCCCCCCCCC	56.30	-
125	Phosphorylation	PKQPPSGTALKQPAV CCCCCCCCCCCCCEE	32.90	-
134	Phosphorylation	LKQPAVVYPWMKKVH CCCCEEEECCCCEEE	5.65	24043423
177	Methylation	EKEFHFNRYLTRRRR HHHHHHHHHHHHHHH	27.22	-
178	Phosphorylation	KEFHFNRYLTRRRRI HHHHHHHHHHHHHHH	17.33	-
223	Phosphorylation	PNTKGRSSSSSSSSS CCCCCCCCCCCCCCC	32.64	30576142
224	Phosphorylation	NTKGRSSSSSSSSSC CCCCCCCCCCCCCCC	35.17	30576142
225	Phosphorylation	TKGRSSSSSSSSSCS CCCCCCCCCCCCCCC	35.87	-
226	Phosphorylation	KGRSSSSSSSSSCSS CCCCCCCCCCCCCCC	35.87	-
227	Phosphorylation	GRSSSSSSSSSCSSS CCCCCCCCCCCCCCC	35.87	30576142
233	Phosphorylation	SSSSSCSSSVAPSQH CCCCCCCCCCCCHHH	32.91	-
234	Phosphorylation	SSSSCSSSVAPSQHL CCCCCCCCCCCHHHC	13.15	30576142
253	Phosphorylation	KDHHTDLTTL----- CCCCCCCCCC-----	28.94	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HXD4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXD4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXD4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RXRG_HUMAN	RXRG	physical	20211142
SNAI1_HUMAN	SNAI1	physical	20211142
DEDD_HUMAN	DEDD	physical	20211142
HXB13_HUMAN	HOXB13	physical	20211142
ZMY11_HUMAN	ZMYND11	physical	20211142
RNPS1_HUMAN	RNPS1	physical	20211142
ZBT32_HUMAN	ZBTB32	physical	20211142
CNOT7_HUMAN	CNOT7	physical	20211142
ZSC18_HUMAN	ZSCAN18	physical	20211142
ASB8_HUMAN	ASB8	physical	20211142
TIGD4_HUMAN	TIGD4	physical	20211142
ANKH1_HUMAN	ANKHD1	physical	28514442
ACTBL_HUMAN	ACTBL2	physical	28514442
ANR17_HUMAN	ANKRD17	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.