TIGD4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIGD4_HUMAN
• UniProt AC: Q8IY51
• Protein Name: Tigger transposable element-derived protein 4
• Gene Name: TIGD4
• Organism: Homo sapiens (Human).
• Sequence Length: 512
• Subcellular Localization: Nucleus .
• Protein Sequence: MAEASVDASTLPVTVKKKKSLSIEEKIDIINAVESGKKKAEIAAEYGIKKNSLSSIMKNKDKVLEAFESLRFDPKRKRLRTAFYTDLEEALMRWYRIAQCLNVPVNGPMLRLKANDFAQKLGHNDFKCSNGWLDRFKSRYGLVFRAQPVEATGVPVDPSTVWYQNVLPYYLNDYHPKNVFNIKETGLLYRMLPTNTFAFKGETCSVGKLCKDRITLVVGTNMDGSEKLPLLVIGKKRTPHCFKGLKSLPVCYEANRMAWMTSDVFEQWMRKLDEEFQAQQRRVVIFVESFPAHPEVKNLKSIELAFFPSCLSSKCIAMKQGVIKSLKIKYRHCLIKKFLSSVEGSKEFTFSLLDAVDTLHLCWRAVTPETIVKSYEEAGFKSQKGESDITNAEKDTGLDLVADALGAGVEFPEGLSIEEYAALDDDLETCEAAPNGDSICTKESKSDETGFYTSDEEDDDGSPGTELPLPSKSEAITALDTLKKFLRSQDMNDGLQNSLADLENFINSLSPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAEASVDASTLP ---CCCCCCCCCCCC	16.43	28387310
14	Phosphorylation	DASTLPVTVKKKKSL CCCCCCCEEEECCCC	25.35	28387310
55	Phosphorylation	IKKNSLSSIMKNKDK CCHHCHHHHHCCHHH	31.81	-
81	Phosphorylation	PKRKRLRTAFYTDLE HHHHHHHHHHCCCHH	26.22	-
84	Phosphorylation	KRLRTAFYTDLEEAL HHHHHHHCCCHHHHH	9.25	-
85	Phosphorylation	RLRTAFYTDLEEALM HHHHHHCCCHHHHHH	27.88	-
215	Phosphorylation	KLCKDRITLVVGTNM HHCCCCEEEEEEECC	17.88	29759185
220	Phosphorylation	RITLVVGTNMDGSEK CEEEEEEECCCCCCC	18.76	29759185
225	Phosphorylation	VGTNMDGSEKLPLLV EEECCCCCCCCCEEE	27.56	29759185
330	Phosphorylation	IKSLKIKYRHCLIKK HHHHHHHHHHHHHHH	14.73	22817900
345	Phosphorylation	FLSSVEGSKEFTFSL HHHCCCCCCCCHHHH	18.59	22985185
375	Phosphorylation	PETIVKSYEEAGFKS HHHHHHHHHHCCCCC	16.45	17525332
382	Phosphorylation	YEEAGFKSQKGESDI HHHCCCCCCCCCCCC	34.56	17525332
471	Phosphorylation	GTELPLPSKSEAITA CCCCCCCCHHHHHHH	57.40	24719451
471	O-linked_Glycosylation	GTELPLPSKSEAITA CCCCCCCCHHHHHHH	57.40	29351928
508	Phosphorylation	DLENFINSLSPK--- HHHHHHHHCCCC---	25.96	24719451
510	Phosphorylation	ENFINSLSPK----- HHHHHHCCCC-----	30.39	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIGD4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIGD4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIGD4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KBP_HUMAN	KIAA1279	physical	26186194
KBP_HUMAN	KIAA1279	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-375 AND SER-382, ANDMASS SPECTROMETRY.
PubMed: 17525332