ZSC18_HUMAN - dbPTM
ZSC18_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZSC18_HUMAN
UniProt AC Q8TBC5
Protein Name Zinc finger and SCAN domain-containing protein 18
Gene Name ZSCAN18
Organism Homo sapiens (Human).
Sequence Length 510
Subcellular Localization Nucleus .
Protein Description May be involved in transcriptional regulation..
Protein Sequence MLPLEKAFASPRSSPAPPDLPTPGSAAGVQQEEPETIPERTPADLEFSRLRFREFVYQEAAGPHQTLARLHELCRQWLMPEARSKEQMLELLVLEQFLGILPDKVRPWVVAQYPESCKKAASLVEGLADVLEEPGMLLGSPAGSSSILSDGVYERHMDPLLLPGELASPSQALGAGEIPAPSETPWLSPDPLFLEQRRVREAKTEEDGPANTEQKLKSFPEDPQHLGEWGHLDPAEENLKSYRKLLLWGYQLSQPDAASRLDTEELRLVERDPQGSSLPEGGRRQESAGCACEEAAPAGVLPELPTEAPPGDALADPPSGTTEEEEEQPGKAPDPQDPQDAESDSATGSQRQSVIQQPAPDRGTAKLGTKRPHPEDGDGQSLEGVSSSGDSAGLEAGQGPGADEPGLSRGKPYACGECGEAFAWLSHLMEHHSSHGGRKRYACQGCWKTFHFSLALAEHQKTHEKEKSYALGGARGPQPSTREAQAGARAGGPPESVEGEAPPAPPEAQR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationPLEKAFASPRSSPAP
CHHHHCCCCCCCCCC		17.8830278072
13PhosphorylationKAFASPRSSPAPPDL
HHCCCCCCCCCCCCC		44.0226657352
14PhosphorylationAFASPRSSPAPPDLP
HCCCCCCCCCCCCCC		26.7626657352
22PhosphorylationPAPPDLPTPGSAAGV
CCCCCCCCCCCCCCC		47.8027732954
66PhosphorylationEAAGPHQTLARLHEL
HHHCHHHHHHHHHHH		21.2527251275
70PhosphorylationPHQTLARLHELCRQW
HHHHHHHHHHHHHHH		2.8327251275
75MethylationARLHELCRQWLMPEA
HHHHHHHHHHHCHHH		43.2530763599
75DimethylationARLHELCRQWLMPEA
HHHHHHHHHHHCHHH		43.25-
118 (in isoform 1)Ubiquitination-55.5121890473
118 (in isoform 2)Ubiquitination-55.5121890473
118UbiquitinationAQYPESCKKAASLVE
HHCCHHHHHHHHHHH		55.51-
140PhosphorylationEPGMLLGSPAGSSSI
CCCCCCCCCCCCCCC		16.1424719451
144PhosphorylationLLGSPAGSSSILSDG
CCCCCCCCCCCCCCC		24.0228857561
145PhosphorylationLGSPAGSSSILSDGV
CCCCCCCCCCCCCCC		22.0828857561
146PhosphorylationGSPAGSSSILSDGVY
CCCCCCCCCCCCCCH		29.2829523821
149PhosphorylationAGSSSILSDGVYERH
CCCCCCCCCCCHHHC		30.5629523821
153PhosphorylationSILSDGVYERHMDPL
CCCCCCCHHHCCCCC		16.8729523821
168PhosphorylationLLPGELASPSQALGA
CCCCCCCCHHHHCCC		37.4028348404
170PhosphorylationPGELASPSQALGAGE
CCCCCCHHHHCCCCC		26.1128348404
174 (in isoform 3)Ubiquitination-34.25-
174UbiquitinationASPSQALGAGEIPAP
CCHHHHCCCCCCCCC		34.2521890473
188PhosphorylationPSETPWLSPDPLFLE
CCCCCCCCCCHHHHH		24.3228348404
217 (in isoform 2)Ubiquitination-58.0221890473
217UbiquitinationANTEQKLKSFPEDPQ
CCHHHHHHHCCCCHH		58.0221890473
217 (in isoform 1)Ubiquitination-58.0221890473
224PhosphorylationKSFPEDPQHLGEWGH
HHCCCCHHHCCCCCC		57.6827251275
240 (in isoform 2)Ubiquitination-57.9621890473
240 (in isoform 1)Ubiquitination-57.9621890473
240UbiquitinationDPAEENLKSYRKLLL
CHHHHHHHHHHHHHH		57.9621890473
244 (in isoform 2)Ubiquitination-34.9421890473
244 (in isoform 1)Ubiquitination-34.9421890473
244UbiquitinationENLKSYRKLLLWGYQ
HHHHHHHHHHHHHHH		34.942189047
244PhosphorylationENLKSYRKLLLWGYQ
HHHHHHHHHHHHHHH		34.9427251275
253PhosphorylationLLWGYQLSQPDAASR
HHHHHHCCCCCHHHC		24.9228348404
273UbiquitinationLRLVERDPQGSSLPE
HHHHEECCCCCCCCC		46.8021890473
273 (in isoform 3)Ubiquitination-46.80-
296UbiquitinationGCACEEAAPAGVLPE
CCCCCCCCCCCCCCC		9.5821890473
296 (in isoform 3)Ubiquitination-9.58-
300UbiquitinationEEAAPAGVLPELPTE
CCCCCCCCCCCCCCC		9.7721890473
300 (in isoform 3)Ubiquitination-9.77-
349PhosphorylationESDSATGSQRQSVIQ
CCCCCCHHHHCHHHC		20.17-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZSC18_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZSC18_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZSC18_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZSC18_HUMAN

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Related Literatures of Post-Translational Modification

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